... (ECL) cells, which are present in the oxyntic mucosa. The ECL cells, which in the rat produce and store histamine (in addition to an as yet unidentified peptide hormone), are known to be activated by gastrin. In rats given high doses of omeprazole, the serum gastrin levels rose about 10-fold. General...

... (ECL) cell hyperplasia and carcinoid tumor formation. We examined the effect of a selective Hi-histamine antagonist, terfenadine, on gastric mucosal cell proliferation to determine whether histamine might modulate ECL cell generation. Methods: The rodent mastomys received the H 2 -antagonist loxtidine...

... on the cell surface on day 18. In contrast, histamine (0.1-100 μ M ), carbachol (0.1-100 μ M ), gastrin-17 (0.1-100n M ), epidermal growth factor (0.01-10 ng/ ml; 1.7-1,700 p M ), transforming growth factor-α (0.01-10 ng/ml; 1.8-1,800 p M ), and fetal bovine serum (1-10%) did not increase glycoconjugate...

... disease, hormonal symptoms and increased urinary excretion of the main histamine metabolite, MelmAA. Five patients with A-CAG tumors were subjected to antrectomy to remove hypergastrinemia, which is thought to be of pathogenetic importance for these tumors. During the observation period (1.5-8 years) 1...

... tumors) following lifelong treatment with blockers of acid secretion. These observations touched off concern about the safety of the long-term clinical use of such drugs. The ECL cells are the predominant endocrine cell population in the oxyntic mucosa. They produce histamine, chromogranin...

...Irvin M. Modlin; Gary P. Lawton; Laura H. Tang; John Geibel; Reginald Abraham; Umer Darr The mastomys rodent exhibits a genetic propensity to develop gastric carcinoid tumors. Utilizing acid inhibitory pharmacotherapy (histamine-2 receptor antagonists and proton pump inhibitors), we have...

... h after dosing, reflecting complete (2 h) and 70-80% (24 h) reductions of gastric acid secretion. Administration of either drug for 10 weeks increased the weight of the stomach and the oxyntic mucosa. The oxyntic mucosal histidine decarboxylase activity, histamine concentration and ECL cell density...

... was performed by subcutaneous injection of capsaicin for 3 days (total dose: 100 mg/kg) 2 weeks before the experiment. This treatment did not cause by itself any damage in the duodenum. However, intravenous infusion of histamine (4, 8 and 16 mg/kg/h) in these animals caused hemorrhagic lesions in the proximal...

...Kjell Andersson; Hillevi Mattsson; Håkan Larsson The role played by histamine from enterochromaffin-like (ECL) cells and mast cells in gastric acid secretion and in the development of ethanol-induced gastric lesions was studied in the rat. This was done by examining the effects of inhibition...

... the occurrence of ranitidine in plasma, strongly suggesting that the hypergastrinaemia was secondary to inhibition of acid secretion. Following 20 weeks treatment with ranitidine, both the relative weight of the stomach and that of the oxyntic mucosa were increased. The oxyntic histamine concentration and ECL...

...Gary B. Glavin; Jon M. Gerrard N, N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine HCl (DPPE) is an anti-histamine with a unique profile of activity in the stomach. It is antisecretory and blocks the formation of experimental cold/stress- and ethanol-induced gastric lesions, as well as cys-teamine...

... with a gastric fistula during a background stimulation of gastric secretion by continuous infusions of pentagastrin, bethanechol or histamine. During infusion of pentagastrin or histamine, BRL 24924, by itself, influenced gastric secretion with stimulation during a low potent background stimulation...

... acid secretion induced by histamine but all of them caused a dose-dependent inhibition of acid secretion from the gastric fistula (GF) and Heidenhain pouches (HP) stimulated by pentagastrin and bethanechol, telenzepine being 5–9 times more potent than pirenzepine and equipotent with atropine. All...

...S. Janković; D. Beleslin Both human and guinea pig gallbladder strips were tonically contracted by supramaximal concentrations of histamine in vitro. Guinea pig gallbladder strips were also tonically contracted by potassium, with no spontaneous relaxation after 5 min. The amplitude...

... cells. We therefore studied their effect on gastric acid production in vitro by measuring [ 14 C]-aminopyrine accumulation, a reliable index of H + generation, in isolated rat parietal cells. However, neither gastrin-releasing peptide nor oxyntomodulin influenced basal acid secretion or histamine...

...Koji Takeuchi; Osamu Furukawa; Megumu Okada; Susumu Okabe Mongrel dogs of either sex, weighing 14.0 ± 0.7 kg, were given indomethacin orally in a dose of 70 mg/dog, and they were deprived of food thereafter. Twelve hours later, the animals were given histamine-2HCl intramuscularly 4 times every...

... Cimetidine H2 blocker Gastric mucosa Acid secretion Cytoprotection Histamine Original Papers Digestion 41: 1-8 (1988) © 1988 S. Karger AG , Basel 0012-2823/88/0411-0001 $2.75/0 Gastric Mucosal Resistance and Prostanoid Levels after Cimetidine Treatment in Rats Tetsuo Arakawa, Hiroshi Satoh, Takashi...

...H.L. Waldum; E. Brenna; A.K. Sandvik; P.M. Kleveland; H. Petersen; B. Søgnen The etiology of peptic ulcer disease is completely unknown. However, gastric acid secretion plays an important role in the pathogenesis of the disease. Acetylcholine, gastrin and histamine are recognized as the main...

...P. Haentjens; E. Beckers; G. Willems Variations in the size of the antral G and D cell populations under the effect of chronic stimulation of acid secretion with histamine were investigated in male Wistar rats. Osmotic minipumps delivering either 0.9% saline or histamine dihydrochloride (4.5 mg/kg...

... gastric glandular ulceration. Indomethacin given beforehand did not influence the protective action of zinc sulphate against ethanol-evoked lesions. Ethanol decreased histamine levels, whereas indomethacin reduced the prostaglandin E 2 (PGE 2 ) content in the gastric glandular mucosa. The alcohol also...