...Kenta Hashigami; Yugo Iwaya; Tadanobu Nagaya; Daichi Hara; Atsuhiro Hirayama; Takuma Okamura; Taiji Akamatsu; Takeji Umemura Introduction: Helicobacter pylori eradication therapy may worsen gastroesophageal reflux disease that is a significant risk factor for Barrett’s esophagus. However...

... a comprehensive diagnostic approach while observing the sphincter from a retroflex view on the stomach side. By integrating these dynamic findings, functional endoscopy offers an efficient method for diagnosing functional gastrointestinal diseases, such as gastroesophageal reflux disease (GERD). Key Messages...

.... 2023 Gastroesophageal reflux disease Esophageal motility disorders Esophageal achalasia The development of high-resolution manometry (HRM) has advanced our understanding of esophageal motility disorders. Accurate manometric diagnoses lead to specific treatments such as long myotomy...

... be misdiagnosed as proton pump inhibitors (PPI)-refractory gastroesophageal reflux disease (GERD). In patients with reflux symptoms, distinguishing these conditions is essential because they need psychological treatment (i.e., cognitive behavioral therapy (CBT) rather than acid suppressants. Clinicians should...

..., instructions or products referred to in the content or advertisements. 2023 Esophageal motility disorders Esophageal achalasia Gastroesophageal reflux disease The esophagus transports a bolus from the pharynx into the stomach. The upper/lower esophageal sphincter (UES/LES) and esophageal...

...Kazuhiro Ota; Toshihisa Takeuchi; Kazuhide Higuchi; Shun Sasaki; Yosuke Mori; Hironori Tanaka; Akitoshi Hakoda; Noriaki Sugawara; Taro Iwatsubo; Hiroki Nishikawa Background: The 3rd edition of the evidence-based clinical practice guidelines for gastroesophageal reflux disease (GERD) 2021 from...

...Yoshimasa Hoshikawa; Eri Momma; Noriyuki Kawami; Katsuhiko Iwakiri Introduction: Esophageal hypersensitivity is associated with gastroesophageal reflux disease (GERD). Since sleep disturbance causes esophageal hypersensitivity, hypnotics may ameliorate GERD. However, zolpidem prolongs esophageal...

... Kojima; Kazuhide Higuchi Introduction: In patients with gastroesophageal reflux disease (GERD) on maintenance therapy with acid-suppressive drugs, it is not clear what background factors allow patients to discontinue the drugs. The aims of this study were to examine the relationship of the changes...

... QOL by means of GIQLI in patients with gastroesophageal reflux disease (GERD) prior to any interventional therapy. There are several reports on GIQLI data; however, comparisons from different countries and/or different GERD cohorts assessing the same disease have to date not been conducted. Methods...

...Noriaki Manabe; Kazuhiro Matsueda; Ken Haruma Background: Similar trends in the prevalence of gastroesophageal reflux disease (GERD), obesity, and Helicobacter pylori infection have been observed in Asian and Western countries despite their time differences. However, it is unclear whether...

... blocker Proton pump inhibitor H2 receptor antagonist Gastroesophageal reflux disease Functional dyspepsia Antacid medications, including potassium-competitive acid blockers, proton pump inhibitors (PPI), and/or H 2 receptor antagonists, which suppress gastric acid secretion, are widely used...

... of gastroesophageal reflux disease (FSSG) total score ≥8 after at least 8 weeks of treatment with standard proton pump inhibitors (PPIs). These patients were switched to VPZ 20 mg for 4 weeks. We also enrolled 71 patients with no endoscopic evidence of erosive esophagitis who received maintenance therapy with VPZ 10...

... of vonoprazan (VPZ), a novel potassium-competitive acid blocker, in patients with proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD), exhibiting continued pathological esophageal acid exposure (EAE). Methods: Despite ≥8 weeks of appropriate PPI therapy, patients with ­persistent...

... cavity, was also evaluated. UES relaxation without swallowing was defined as a break in the 20 mm Hg isobaric contour at the high-pressure zone of UES. A common cavity was defined as an abrupt increase of intraesophageal pressure by > 5 mm Hg [ 24 ]. Gastroesophageal reflux disease Lower...

..., and the increased interest of physicians in the gastroesophageal junction. The number of gastroesophageal reflux disease patients in Japan rapidly increased from the 1990s, which accordingly increased the number of Barrett’s esophageal adenocarcinoma patients from the latter half of the 1990s. Tabulation...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2018 Sleep disturbance Gastroesophageal reflux disease Functional dyspepsia...

...; Zenshiro Tamaki; Mitsuhiro Fujishiro; Yoshihide Asano; Shinichi Sato; Kazuhiko Koike Background/Aims: Gastroesophageal reflux disease (GERD)-related disorders of systemic sclerosis (SSc) patients have not been adequately investigated. Methods: Sixty-six SSc patients (5 males and 61 females; 56.6 ± 14.6...

...Lukas Winkelsett; Peter Malfertheiner; Thomas Wex; Arne Kandulski Background: Activation of protease-activated receptor-2 (PAR2) is involved in the mucosal immune pathogenesis of gastroesophageal reflux disease (GERD) that is characterized by proinflammatory cytokines such as interleukin-8 (IL-8...

... of gastroesophageal reflux disease (GERD). Recently, the assessment of esophageal baseline impedance (BI) using the multichannel intraluminal impedance-pH (MII-pH) test was suggested as a surrogate technique for the study of esophageal mucosal integrity and was reported to be useful in distinguishing GERD from non...

... gastrointestinal motility disorder. Studies have reported that IEM is related to gastroesophageal reflux disease (GERD). However, the relationship between IEM and GERD remains uncertain. This study aims to clarify this relationship retrospectively. Methods: We analyzed 195 subjects who underwent high-resolution...