..., the animals were sacrificed, and histological examination was performed on the 3 stomachs that could be extirpated. Results: (1) On day 7, adhesion of HAG sheets was observed. (2) Gastric ulcer area on day 7 was significantly larger in the covered ulcers than in the non-covered ulcers ( p = 0.046). On day 14...

...Kyung Ho Song; Yong Chan Lee; Dai-Ming Fan; Zhi-Zheng Ge; Feng Ji; Min-Hu Chen; Hyun Chae Jung; Jiang Bo; Sang Woo Lee; Jin-Ho Kim Background and Aims: A recent placebo-controlled trial showed that rebamipide, which is a mucosal-protective antiulcer agent, promoted gastric ulcer healing without...

..., respectively, i.e. a difference of 471.9 JPY. Conclusions: A reduced dose of PPI after 1 week of ESD was equivalent in treatment performance to the standard dose and cheaper. Lansoprazole Randomized controlled trial Gastric ulcer Ulcer healing Sample size was calculated based on the study...

... and energy expenditure, exerts pleiotropic cytokine-like biological effects. Its role in gastric ulcer healing is unclear. In this study, we investigated the role of leptin in gastric ulcer healing. Methods: Experimental gastric ulcer was induced by focal serosal application of acetic acid in leptin...

... functions in extracellular matrix remodeling, cell proliferation, and inflammatory processes. Here, we compared MMP-3 levels with those of tissue inhibitor of metalloproteinases (TIMP)-1 and several inflammatory cytokines in gastric ulcer (GU) patients. Methods: This study enrolled 50 patients with GU and 6...

...Hiroshi Endo; Yoshihisa Tsukamoto; Tomiyasu Arisawa; Hidemi Goto; Satoshi Hase; Tetsuo Hayakawa We studied the chronic effect of ammonia, which is one of the pathogenic factors of Helicobacter pylori in gastroduodenal diseases, on the healing of acetic acid-induced gastric ulcers in rats...

..., 10, or 40 mg/kg/day. L -NAME dose-and time-dependently enhanced stress-induced gastric ulceration but did not affect mucosal mast cell population. Ulcerogenic actions of L -NAME were reversed by L -arginine but not by D -arginine. Ten-day L -NAME treatment also enhanced the ethanol-induced gastric...

...Yuji Naito; Toshikazu Yoshikawa; Tomoyuki Yoneta; Nobuaki Yagi; Kiichi Matsuyama; Masahiro Arai; Toru Tanigawa; Motoharu Kondo We developed a new gastric ulcer model in which the ulcers are induced by the local injection of a ferrous iron and ascorbic acid (Fe/ASA) solution into the gastric wall...

...Interdisciplinary Group for Ulcer Study This multicenter, prospective, randomized, open, long-term study compares sucralfate (2 g daily) with ranitidine (150 mg daily) and no treatment in gastric ulcer (GU). We report the results of the second year of a scheduled 3-year follow-up, the outcome...

...Leo R. Fitzpatrick; Anna Jakubowska; Gregory E. Martin; Marjorie Davis; Michael C. Jaye; Craig A. Dionne Acidic fibroblast growth factor (aFGF) was evaluated for the healing of acetic-acid-induced gastric ulcers in rats. The effect of aFGF on angiogenesis in the gastric ulcer bed was determined...

..., in 6 patients with benign gastric ulcer and in 8 patients with gastric adenocarcinoma. In normal subjects, SST induced a significant increase in gastric intraluminal PGE 2 concentration and output, whereas it did not augment the concentration and output of PGE 2 in patients with gastric ulcer...

...A. Walan Omeprazole has been shown to provide more rapid symptom relief and to heal ulcers more quickly and reliably than H 2 -receptor antagonists in duodenal ulcer, gastric ulcer and reflux oesophagitis. In addition, omeprazole is well tolerated and has a good safety profile. Among the areas...

... these goals. A series of meta-analyses shows that omeprazole gives more rapid symptom relief and more reliable healing than the H 2 -receptor antagonist, ranitidine, in uncomplicated duodenal ulcer (DU), in uncomplicated gastric ulcer (GU) and in reflux oesophagitis (RO). By contrast with the H 2 -receptor...

...C.B.H.W. Lamers Due to its potent and long-lasting antisecretory properties is omeprazole, the first clinically used H + /K + -adenosine triphosphatase inhibitor, highly effective in healing of duodenal and gastric ulcers and reflux oesophagitis. Omeprazole is superior to all other presently...

... in healing rates in favour of omeprazole were 12–33%; while they were somewhat lower at 4 weeks, ranging from 4 to 20 %. In most studies the difference in healing rate was statistically significant. In some studies pain relief at 2 weeks was more pronounced on omeprazole. In three gastric ulcer studies...

.... H+K+-adenosine triphosphatase Omeprazole H2-receptor antagonists Reflux oesophagitis Zollinger-Ellison syndrome Duodenal ulcer Gastric ulcer Refractory ulcer Abstract. The development of H+/K+-adenosine triphosphatase inhibitors with their po­ tent and long-acting antisecretory action...

...Masaru Okuhira; Toshiaki Nakano; Tomoko Kitajima; Masanori Maruoka; Arata Hiramatsu; Takako Mizuno; Kyoichi Inoue We studied the proliferative ability of the marginal mucosal cells surrounding the ulcer in the healing processes of gastric ulcers. We obtained a labeling index (LI) at the neck...

... in duodenal ulcer (DU) after 4 weeks’ treatment with CBS is 78 % versus 63 % with cimetidine. In a direct comparison, CBS gives 84% healing as opposed to 78 % with ranitidine. The average healing rate after 4 weeks’ treatment with CBS in gastric ulcer (GU) is 68% compared to 54% with cimetidine...

..., instructions or products referred to in the content or advertisements. 1988 Stress Epithelial cell proliferation Gut mucosa Gastric erosions Gastric mucosa Gastric ulcer Digestion 40: 212-218 (1988) © 1988 S. Karger AG. Basel 0 0 12-2823/88/0404-0212S2.75/0 Influence of Stress on Epithelial...

...H.G. Dammann; T.A. Walter; E. Hentschel; P. Müller; B. Simon We conducted an 8-week, double-blind, randomized, placebo-controlled multicenter trial (Austria and Germany) to determine whether famotidine would speed healing or relief of symptoms in patients with benign gastric ulcer. Of the 65...