... esomeprazole (20 mg, b.i.d.), AMX (500 mg, q.i.d.) and STFX (100 mg, b.i.d.; 10-day EAS). The eradication rate and the rate of antibiotic resistance to H. pylori were compared with 2 previous reports about STFX-containing third-line rescue therapies in 2009–2011 and 2012–2013. To explore the association...

... eradication therapy compared with our randomized control trial using second-generation proton pump inhibitor (PPIs). Methods: (First study) A total of 147 patients who have H. pylori infection were randomly assigned to receive either, esomeprazole (EPZ) group and rabeprazole (RPZ) group. (Second study) 1,688...

.... Methods: A total of 874 patients were enrolled; 431 received esomeprazole (EPZ) and 443 received VPZ. First-line regimens contained clarithromycin (CAM) 200 mg b.i.d., amoxicillin 750 mg b.i.d., and either EPZ 20 mg b.i.d. or VPZ 20 mg b.i.d. for 7 days. Metronidazole 250 mg b.i.d. replaced CAM...

...Kenji Furuta; Kyoichi Adachi; Masahito Aimi; Shino Shimura; Hironobu Mikami; Nobuhiro Nishimura; Norihisa Ishimura; Shunji Ishihara; Kohji Naora; Yoshikazu Kinoshita Background: Esomeprazole has been reported to show a strong acid suppression following preprandial as compared to postprandial...

... sufficient acid inhibition for all subjects, particularly in extensive metabolizers (EMs) of CYP2C19. Whether esomeprazole at a dose of 20 mg four times daily dosing (q.i.d.) can attain sufficient acid inhibition throughout 24 h in EMs remains unclear. We therefore investigated the efficacy of esomeprazole...

... study was to evaluate the influence of an escalating medical anti-reflux therapy with 40 mg esomeprazole, 80 mg esomeprazole and 80 mg esomeprazole plus baclofen for the treatment of refractory pathological reflux as determined by pH/MII. Methods: Symptomatic patients under 40 mg esomeprazole were...

... to quality of life (QOL) were ascertained. Methods: Seventy-four patients with GORD symptoms (age 51 years (22–78); ♂62%) derived from primary care completed the RDQ, GSRS and QOLRAD before and after a 2 weeks’ course of esomeprazole 40 mg daily. The SAP was determined by a 24-hour pH recording before PPI...

...Xia Wang; Jing-Yuan Fang; Rong Lu; Dan-Feng Sun Background: To assess effects of esomeprazole-based therapies and others (PPIs) on Helicobacter pylori eradication when co-administered with antibiotics. Goals: Using the terms ‘ H. pylori eradication’ and ‘esomeprazole’, we searched Medline, Embase...

...Herbert Schneider; Christoffel van Rensburg; Stephen Schmidt; Nazimuddin Aboo; Heli Mäkelä; Emma Nauclér; Bengt Hallerbäck; Lars-Erik Svedberg Background/Aims: An intravenous formulation of esomeprazole has been developed for use in patients where oral administration is not appropriate. This study...

...Clive H. Wilder-Smith; Kerstin Röhss; Catharina Nilsson-Pieschl; Ola Junghard; Lars Nyman Aim: To compare the effects of standard-dose esomeprazole with those of standard doses of lansoprazole and rabeprazole on intragastric pH during repeated daily oral dosing in healthy volunteers. Methods...