...Akira Sonoda; Kazuhiro Mizukami; Soh Okano; Takanori Nishiguchi; Dai Yamazaki; Yoshimasa Horie; Tsubasa Tateishi; Yuichi Saito; Yuki Hirose; Hirohito Sano; Satoshi Saito; Masakazu Takazoe; Shiho Iwamoto; Minako Sako; Masayuki Fukata Introduction: Patients with Crohn’s disease (CD) require...

...Masanao Nakamura; Takeshi Yamamura; Keiko Maeda; Tsunaki Sawada; Eri Ishikawa; Kentaro Murate; Kazuhiro Furukawa; Takashi Hirose; Kota Uetsuki; Tadashi Iida; Yasuyuki Mizutani; Kentaro Yamao; Yoji Ishizu; Takuya Ishikawa; Takashi Honda; Hiroki Kawashima Introduction: Crohn’s disease (CD) induces...

...Nina Bauer; Claudia Löffler; Oezlem Oeznur; Christine Uecker; Christoph Schlee; Alexandra Adamczyk; Sigrid Elsenbruch; Katrin Pfuhlmann; Ralf Reissmann; Astrid Westendorf; Thomas Keil; Jost Langhorst Introduction: Stress and lifestyle factors impact the course of Crohn’s disease (CD). Our primary...

..., the prevalence and types of EIMs, which are defined based on previous reports and the Japanese guidelines, were investigated. Results: This cohort enrolled 728 patients, including 542 ulcerative colitis (UC) and 186 Crohn’s disease (CD). Of these patients with IBD, 10.0% were identified with one or more EIMs (57...

...Fumihito Hirai; Akihito Uda; Mihoko Ota; Yukiko Takemura; Keisuke Tanaka; Ryuichi Iwakiri Introduction: Crohn’s disease (CD) is a chronic inflammatory condition affecting any part of the gastrointestinal tract. Current therapies involve pharmacological efforts to dampen inflammation. Biologics...

.... Biomarkers play five major roles in the management of IBD: (1) diagnosing and distinguishing between IBD and non-IBD or ulcerative colitis and Crohn’s disease; (2) predicting treatment response, especially before administrating biologics; (3) monitoring and grasping endoscopic or histological disease...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2022 Inflammatory bowel disease Crohn’s disease Ulcerative colitis Cellular...

... of endoscopic healing cannot be achieved by ileocolonoscopy alone in patients with Crohn’s disease (CD). Summary: Approximately 70–80% of patients with CD have small bowel disease, and intestinal complications develop more frequently in the small bowel than in the colorectum. The recent advent of small bowel...

..., and therefore, spontaneous repair of damaged tissue is required to restore the function and long-term homeostasis of the intestinal mucosa. Also, in patients with refractory Crohn’s disease, loss of massive intestinal function can lead to short bowel syndrome or may lead to fatal intestinal failure. Summary...

...Filippo Vernia; Angelo Viscido; Mirko Di Ruscio; Gianpiero Stefanelli; Marco Valvano; Giovanni Latella Introduction: The need for noninvasive markers of disease activity is mandatory in the assessment of Crohn’s disease (CD). The most widely fecal biomarker in CD, despite several limits, is fecal...

... in patients with Crohn’s disease (CD) and ulcerative colitis (UC). Methods: Using data obtained in a prospective, multicenter, observational study (PLANET), we assessed serial changes in a novel biomarker – leucine-rich alpha-2 glycoprotein (LRG) – during ADA treatment for patients with active CD and UC. We...

... 42.7 years old, 70% with Crohn’s disease, 78% receiving immunosuppressive treatment), only 33% had an immunization record available. Absence of seroprotection against tetanus (6%) was associated with increasing age and absence of booster dose; absence of seroprotection against varicella (1%) or measles...

... associated with disease activity in Crohn’s disease (CD). We assessed whether there is a correlation between vitamin D levels and the risk of postoperative recurrence in CD. Methods: CD patients who underwent surgery were identified from a prospectively maintained database at the University of Chicago...

...Nobuyasu Arai; Takahiro Kudo; Kazuhide Tokita; Reiko Kyodo; Masamichi Sato; Eri Miyata; Kenji Hosoi; Tamaki Ikuse; Keisuke Jimbo; Yoshikazu Ohtsuka; Toshiaki Shimizu Introduction: Anal fistulae have a significant impact on the quality of life of patients with Crohn’s disease (CD). In this cross...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2020 TNF inhibitors Biologicals Crohn’s disease Ulcerative colitis...

... tumor necrosis factor, interleukin (IL)-23 is a promising drug target, and antibodies for the combined inhibition of IL-23 and IL-12 (ustekinumab and briakinumab) or selective IL-23 inhibition (brazikumab, risankizumab, and mirikizumab) seem to be effective in Crohn’s disease (CD) with emerging evidence...

...Michael Christian Sulz; Emanuel Burri; Pierre Michetti; Gerhard Rogler; Laurent Peyrin-Biroulet; Frank Seibold; on behalf of the Swiss IBDnet, an official working group of the Swiss Society of Gastroenterology Background: Treatment of Crohn’s disease (CD) patients is complex as therapy choices...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2020 Extraintestinal manifestations Crohn’s disease Ulcerative colitis Inflammatory bowel disease Infliximab...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2020 Crohn’s disease Ulcerative colitis Elderly Management Intestinal dysbiosis is associated with several chronic conditions, including inflammatory diseases. IBD...

... of the most important factors contributing to the increasing incidence in inflammatory bowel disease (IBD), consisting mainly of Crohn’s disease and ulcerative colitis. Summary: Diet represents a crucially important and intuitively relevant topic for IBD patients. Although a substantial number of patients...