... is the major site of irAEs, and it has recently become evident that the large bowel is the most frequently affected region. The aim of this narrative review was to clarify the endoscopic and histopathologic findings of and treatments for ICI-induced colitis. Summary: Endoscopic findings of ICI-induced colitis...

... in inflammatory bowel disease. We, therefore, investigated the impact of gal-3 on dextran sodium sulfate (DSS)-induced colitis in a mouse model. Methods: Colonic lamina propria fibroblasts of healthy controls were used for co-incubation studies of gal-3 with gal-1, TGF-β1, IFNγ, IL-4 and IL-10. Acute and chronic...

.... 2013 Clostridium difficile Clostridium difficile-associated disease Colitis Fecal microbiota transplantation Metagenomics Microbiome Illumina Hospital-acquired infections with Clostridium difficile are the most common cause of antibiotic-associated diarrhea [ 1 ]. Antibiotic...

...Breanna Chen; Safwat Girgis; Wael El-Matary Background/Aims: The significance of the association between many gastrointestinal pathologies and autism is yet to be discovered. The aim of this report is to highlight an association between autism and microscopic eosinophilic colitis in 2 children...

...S.D. Ryder; A.H. Raouf; N. Parker; R.J. Walker; J.M. Rhodes Patients with ulcerative colitis are usually non- or ex-smokers in contrast to Crohn’s disease where smoking is common. Abnormalities of quantity and quality of intestinal mucus have been postulated in the pathogenesis of these diseases...

... in the colonic mucosa following TNB administration were inhibited in the Z-103 and SASP groups. These results suggest that Z-103 is as effective against TNB-induced colitis as SASP. 25 04 1995 4 02 1997 1 07 1997 © 1997 S. Karger AG, Basel Copyright / Drug Dosage / Disclaimer Copyright...

...Renata Fabia; Aamer Ar’Rajab; Roger Wïllén; Roland Andersson; Bo Ahrén; Käre Larsson; Stig Bengmark The therapeutic effects of exogenous phosphatidylcholine and phosphatidylinositol on acetic acid-induced colitis in rats were evaluated. A uniform colitis developed 4 days after instillation of 4...

...A. Emmanouilidis; O.N. Manousos; Ch. Papadimitriou; J. Triantafyllidis The clinical course and prognosis of ulcerative colitis were studied in a group of 205 Greek patients. The study lasted for 6 years and follow-up was achieved in 98% of the patients. In most patients the disease was confined...

...A.R. Tanner; A.S. Raghunath Over an 18-month period at a single clinic, 43 new cases of colonic inflammation have been diagnosed (19 proctitis only). Crohn’s colitis has been excluded from this analysis. In all these subjects a careful drug history has been taken in a prospective manner and in 4...

...G. Olaison; P. Leandersson; R. Sjödahl; C. Tagesson Patients with Crohn’s colitis were investigated regarding the relationship between intestinal inflammation, mucosal activity of phospholipase A 2 and intestinal permeability to different-sized polyethylene glycols (PEG). Mucosal specimens...

...J.V. Psaila; B. Myers; I.R. Jones; J. Rhodes The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon. Only prostaglandin E2 treatment significantly reduced mucosal ulceration. Long-term exposure of the rat...

...R. Capriili; G. Frieri; G. Latella; P. Vernia; M.L. Santoro The normal colon absorbs water, sodium and chloride and secretes potassium and bicarbonate. In ulcerative colitis (UC), modifications occur in the absorption of water, sodium and chloride, whereas the secretion of potassium remains...

... of the countries, mortality from Crohn’s disease and ulcerative colitis were recorded separately and, during the period, mortality from Crohn’s disease increased in all but one country, in contrast to ulcerative colitis where a fall occurred in each country. In those countries where one of the diseases was common...

... in regulatory control of colonic epithelial cell proliferation. The clinical presentation, histopathology, proliferative alterations, potential premalignancy, and response to pharmaceutic intervention of carrageen-induced colitis in mice support its continued investigation as an animal model for human...

...B. MacPherson; C.J. Pfeiffer Ulcerative colitis and Crohn’s disease are complex, problematic diseases of unknown etiology in man, and appropriate experimental models would be useful in elucidating their pathogenesis and treatment. Although there have been numerous attempts to produce inflammatory...

... Cholecystokinin Colitis Colon neoplasms Cycloheximide Cystic fibrosis Galactose Glycoproteins Goblet cells Hexosamines Intestinal mucosa Intestinal villus Mucins Mucus Peptic ulcer Puromycin Secretion Serotonin Viscosity Recent Advance Digestion / 7: 234 263 (1978) Intestinal Mucins in Health...

... factors Colitis Disseminated intravascular coagulation Dogs Heparin Intestinal mucosa Pancreatic juice Rats Trypsin inhibitors Abstract. Disseminated intravascular coagulation (D1C), experimentally induced by endotoxin, caused severe hemorrhagic necrosis of the intestinal mucosa in dogs...

...B.R. MacPherson; C.J. Pfeiffer Diffuse, topical application of dilute acetic acid to the serosal surface of rat colon, or standardized intraluminal (per rectum) instillation induced a reproducible, diffuse colitis in a dose-response manner. These lesions were reproduced with 100% reliability...

... acid (TNBS) induced colitis model. The response of T cells to TNBS was analyzed by anti-TNBS mixed-lymphocyte reaction. T cell clones were established by limiting dilution. Phenotypes and T cell receptor (TCR) Vβ of T cells were analyzed by flow cytometry. Colitis was induced by administration of TNBS...

... peroxidation, in an in-vivo model of intestinal inflammation. Methods: Colitis was induced by rectal administration of ethanol and trinitrobenzene sulfonic acid in rats. Rats were treated once daily with either lysophosphatidic acid or lysophosphatidylethanolamine rectally or twice daily intraperitoneally...