... study investigated the cytoprotective effect conferred on intestinal epithelial cell lines IRD 98 and IEC 17 against ethanol injury by the synthetic prostaglandin enprostil and compared effects with those of the histamine H 2 -receptor blocker cimetidine. Exposure to 3% ethanol (652 m M ) reduced cell...

... ), but with activities that become significant at ethanol concentrations of more than 100 m M commonly present in the human stomach. Cimetidine was found to be a noncompetitive inhibitor of gastric alcohol dehydrogenase at concentrations as low as 1 m M in vitro. Since the human gastric alcohol dehydrogenase...

.... 1989 Gastro-oesophageal reflux disease Reflux oesophagitis H2-receptor antagonist Cimetidine Ranitidine Famotidine Nizatidine Cisapride Sucralfate Omeprazole Treatment Digestion I989;44(suppl i): 54-62 © 1989 S. Kargcr AG. Basel 0012-282.V89/0447-0054$2.75/0 Management of Gastro...

...W.M. Hui; B.W. Chen; C.H. Cho; C.T. Luk; S.K. Lam We compared the effects of graded doses of misoprostol (50–200 mg), omeprazole (12.5–50 mg), cimetidine (6.25–50 mg) and sucralfate (50–200 mg) on gastric mucosal blood flow as measured by laser Doppler flowmetry and gastric mucosal injury induced...

...A.E. Gent; M.D. Hellier The effect of cimetidine and pirenzepine on the maintenance of healing in duodenal ulceration has been compared in a multi-centre, controlled study. One hundred and sixty-six patients with endoscopically proven duodenal ulceration have been randomised to receive either...

...H.S. Odes; G.M. Fraser; P. Krugliak; S.A. Lamprecht; S. Shany Cimetidine inhibits the action of vitamin D-hydroxylase (a hepatic mixed-function oxidase) in the rat. Therefore, the hypothesis was tested that this H 2 receptor antagonist would affect vitamin D metabolism in humans. Nine adult...

...Takeshi Tsuchida; Yoshihisa Tsukamoto; Kose Segawa; Hidemi Goto; Satoshi Hase We investigated the effects of cimetidine and omeprazole on angiogenesis in granulation tissue and on the healing of gastric ulcers induced by acetic acid in rats. Either cimetidine (50 or 100 mg/kg) or omeprazole (10...

... in duodenal ulcer (DU) after 4 weeks’ treatment with CBS is 78 % versus 63 % with cimetidine. In a direct comparison, CBS gives 84% healing as opposed to 78 % with ranitidine. The average healing rate after 4 weeks’ treatment with CBS in gastric ulcer (GU) is 68% compared to 54% with cimetidine...

...P.R. Salmon A formal single-blind multicentre study has been set up to investigate the probable benefit of combined therapy of the cytoprotective agent De-Nol® (colloidal bismuth subcitrate, CBS) and an acid-suppressing drug (cimetidine) in the treatment of duodenal ulcer. The protocol compares...

...Heinz Hartmann; Ulrich R. Fölsch The efficacy of famotidine, a potent new long-acting H 2 receptor antagonist, was compared with cimetidine in 78 patients with endoscopically proven acute duodenal ulcers. Additional antacid self-medication was allowed if needed for relief of pain. Thirty-nine...

...Tetsuo Arakawa; Hiroshi Satoh; Takashi Fukuda; Hiroyuki Sakuma; Hajime Nakamura; Kenzo Kobayashi We studied the effects of cimetidine administered intraperitoneally to rats at a dose of 20 mg/kg twice daily for 7 days on gastric mucosal integrity and endogenous prostaglandins. Cimetidine...

...R. Riedel; W. Bohnenkamp; M. Eltze; K. Heintze; W. Prinz; W. Kromer In different rat models, the antisecretory and antiulcer effects of the M 1 -antimuscarinics telenzepine and pirenzepine, the nonselective antimuscarinic atropine, and the H 2 -blockers ranitidine and cimetidine were compared...

... was significantly correlated with lesion formation. A mast cell stabilizer, MAR-99 (50 mg/kg), prevented lesion formation and changes in the mast cells. Omeprazole (20 or 60 mg/kg) significantly reduced the gastric lesions, but mast cell changes persisted. Cimetidine (50 mg/kg) could not inhibit compound 48/80...

... in four Spanish hospitals in a randomized double-blind comparative study with cimetidine (800 mg at night). Antacid tablets were allowed as additional treatment, if needed for pain relief. There were no significant differences between the groups in baseline characteristics, including duodenal ulcer size...

... to achieve better results than 10 mg b.i.d. and equivalent to 20 mg t.i.d. Trials comparing famotidine to cimetidine, ranitidine, and gefarnate found the new agent to be approximately equivalent to cimetidine and ranitidine and superior to gefarnate in the treatment of acute duodenal ulcer. Similar trials...

... for long-term therapy of Zollinger-Ellison syndrome, and its onset of action was similar to those of equipotent doses of cimetidine and ranitidine. However, in these patients famotidine was approximately nine times more potent than ranitidine and approximately 32 times more potent than cimetidine...

...Masao Kakei; Susumu Ohara; Kazuhiko Ishihara; Haruya Okabe; Kyoko Hotta The effects of cimetidine on gastric mucus glycoprotein biosynthesis in rat gastric mucosa were investigated using organ culture technique. 2 h following oral administration of cimetidine (40 mg/kg body weight), corpus tissue...

...; E. Vogel; A.L. Blum A double-blind controlled clinical trial on the medical treatment of the acute episode of duodenal ulcer and the prevention of symptomatic relapses was performed. A total of 164 patients with active duodenal ulcer were either treated with cimetidine 1 g/day (70 patients...

...Gábor Varga; Carmelo Scarpignato; Miklós Papp The effect of ranitidine (20 mg•kg -1 ) and cimetidine (50 mg·kg -1 ) on pancreatic secretory and trophic responses to caerulein (1 μg•kg -1 ) was studied in the rat. Ranitidine or cimetidine were administered alone or combined with caerulein twice...

...Håkan Larsson; Enar Carlsson; Gunhild Sundell The effects of omeprazole, a substituted benzimidazole, on gastric acid secretion and on right atrial beating frequency have been investigated in guinea pig preparations in vitro. Cimetidine was used as a reference compound. Omeprazole, at 10 -6 mol/l...