... of cholestasis did not correlate with the observed patterns of transporter alterations (tables 1 , 2 ). Two patients were lost to follow-up and their final outcome was not documented. Neither the latency from drug intake to the development of symptoms nor the timing of liver biopsy after onset of symptoms had...

... success of ERCP with the single balloon enteroscope (SBE) in patients with Roux-en-Y anastomosis. Patients: Patients with Roux-en-Y anastomosis presenting with cholestasis undergoing ERCP with the SBE technique in a tertiary university hospital. Diagnostic success was defined as successful duct...

... postoperatively in temporal relation with cholestatic jaundice. Hepatic biopsies revealed moderate intrahepatic cholestasis and mild lobular inflammatory infiltration with some eosinophils. No histological evidence of acute graft rejection or reactivated hepatitis was found. Treatment with methimazole markedly...

...K. Hakala; M. Vuoristo; TA. Miettinen The role of cholestasis and ileal dysfunction on sterol metabolism was studied in 79 patients with inflammatory bowel diseases (IBDs) and in 23 irritable bowel syndrome (IBS) controls by determining serum sterol/cholesterol proportions. The sterols included...

...P. Marteau; Y. Chrétien; Y. Calmus; R. Parc; R. Poupon Somatostatin (SST) has been shown to induce cholestasis in the dog and in the rat. In man, it is still unknown whether SST modifies bile formation. The present study was undertaken to examine the influence of SST on bile secretion in man. Two...

... biopsy disclosed marked cholestasis, without hepatitis, and was compatible with a rare form of methyldopa-induced liver injury. Cessation of drug treatment was followed by a slow but complete recovery. Cholestasis is a rare manifestation of methyldopa hepatotoxicity. Although methyldopa-associated liver...

... the adverse effects of taurolithocholate (TLCA) which causes cholestasis by altering liver plasma membrane organization. Isolated perfused rat livers from endotoxin-tolerant rats had a lower basal bile flow than control livers. However, a bolus addition of TLCA at 3 × 10 -5 or 5 × 10 -5 M in the perfusate...

...D.R. Williams; P.J. Barter; A.M. Mackinnon Serum lipoprotein cholesterol concentration, lecithinxholesterol acyltransferase (LCAT) activity and lipoprotein X (LP-X) were studied after acute cholestasis had been produced by ligation of the common bile duct in rats fed a liquid fat-free diet...

...F.J. Hoek; R. Grijm; G.T.B. Sanders; G.N.J. Tytgat; J.M. Wilmink Hemodialysis with a polyacrylonitril membrane is evaluated as a possible method to alleviate pruritus accompanying severe prolonged cholestasis. To that extent results of a series of 30 dialysis sessions of a patient with advanced...

...J.P. van de Merwe; M. van Blankenstein; J.H.P. Wilson The case history of a woman with intrahepatic cholestasis is described. She had taken phenylbutazone during 1 month for painful swollen knees. A liver biopsy obtained at surgical exploration revealed pericentral cholestasis and infiltration...

...J. Rubiés-Prat; M.R. Ras; J.C. Frisón; C. Miquel; S. Masdeu; R. Bacardí The effect of heparin on the proportion of cholesterol esters, lecithin/ lysolecithin ratio, and lecithin:cholesterol acyltransferase (LCAT) activity was studied in twelve patients with cholestasis. A good correlation...

...D. Pessayre; G. Feldmann; C. Degott; A. Ulmann; W. Roger; S. Erlinger; J.-P. Benhamou The authors report the case of a patient with transient intrahepatic cholestasis following the administration of a soluble gold salt, sodium aurothiopropanol sulfonate. Other manifestations of intolerance to gold...

... in patients with cholestasis. The in vitro concentration of bile salts required to induce a negative or reduced concentration of LP-X was also studied. There was no relationship, either positive or negative, between serum LP-X and bile acids in 34 patients with cholestasis. Serum was incubated with various...

... Electrophoresis Changes of Lipoprotein-X after Phospholipase A and Deoxycholic Acid J.C Frison, M.R. Ras, J. Rubiés-Prat, S. Masdeu and S. Schwartz Department of Internal Medicine and Laboratory of Biochemistry, Ciudad Sanitaria de la Seguridad Social, Universidad Autónoma, Barcelona Key Words. Cholestasis...

... as evaluated on liver biopsy material was in the normal range. Some of the features observed in this group of patients are reminiscent of alterations previously described in human or experimental cholestasis and suggest that they might depend on a common underlying disturbance in cholesterol and bile salt...

... Phospholipids Gallstones Hyperbilirubinemia Cholestasis Dyes Sulfobromophthalein Cholesterol Cytochrome P-450 Recent Advances Digestion 12: 43-56 (1975) Barbiturates and Biliary Function J.P. Capron and S. Erlinger Unité de Recherches de Physiopathologie hépatique (Inserm), Hôpital Beaujon, Clichy Key...

...A. Stiehl Bile salt sulfates were first detected in 1967 by Palmer who realized that lithocholate in human bile is partially sulfated. Subsequently, sulfate esters of cholate and cheno-deoxycholate were identified in the serum and urine of patients with cholestasis. Sulfation of bile salts...

... duct Carbon tetrachloride Cholestasis Gel nitration Glutamyl transpeptidase Hepatitis Liver cirrhosis Leucine aminopeptidase Liver diseases Liver neoplasm Rats Digestion 5: 326-336 (1972) y-GIutamyl Transpeptidase: a Clinical and Experimental Study1 G. Ideo, A. Morganti and N. D ioguardi...

..., Créteil Key Words Bile Bromsulphalein Cholestasis Contraceptives, oral Enzyme induction Liver function Oestrogens Pregnancy, liver in Progcstogens Oral contraceptives have now been widely used for about 15 years. Since 1964, adverse effects on the liver, with or without jaundice, were reported, most...

...F. Schaffner Editorial Digestion 4: 117-120 (1971) The Molecular Biology of Cholestasis F . SCHAFFNER Department of Pathology, Mount Sinai School of Medicine of the City University, New York Key Words Cholestasis Bile salts Hepatocellular ultrastructure Microsomal biotransformation Endoplasmic...