... on submucosal gland secretion, while buffering in the intercellular space depends on bicarbonate diffusion from blood, and intracellular protection depends on the presence of basolateral membrane bicarbonate transport via a mechanism such as the Na + -dependent CI-/HCO 3 exchanger. Acid Barrier Bicarbonate...

... Center, New Orleans. La., USA Digestion 1995;56(suppl 1):45 50 How Does the Esophageal Epithelium Maintain Its Integrity? Key Words Acid Bicarbonate Buffer capacity Defense Epithelium Esophagus Exchangers Glycoprotein Integrity Repair Abstract The esophageal epithelium maintains its integrity by both...

... Prostaglandin Trimoprostil Oesophagitis Acid Cytoprotection Digestion 44;1989:52-56 ©1989 S. Karger AG. Basel 0 0 12-2823/89/0441-0052S2.75/0 Treatment of Reflux Oesophagitis with Trimoprostil II.L. Smart, P.D. James, M. Atkinson, C.J. Ilawkey University Hospital. Nottingham, UK Keywords. Prostaglandin...

... on the disappearance rate of acid and the concomitant plasma secretin concentrations. 10 healthy subjects were studied twice, with and without indomethacin pretreatment. By means of a double-lumen tube the duodenum was perfused with increasing amounts of acid (0, 3.0, 6.0 and 9.5 mmol/h) and the disappearence rate...

...M. Vagne; M.L. Gelin; T.J. McDonald; J.A. Chayvialle; Y. Minaire The effect of bombesin on acid and pepsin secretion and antral motility was compared to that of pentagastrin in conscious cats. Bombesin stimulated acid secretion to 65 % of the maximal response to pentagastrin but induced a stronger...

...Changcheng Wang; Richard H. Hunt The fundamental abnormality in gastroesophageal reflux disease is exposure of the esophageal epithelium to acidic gastric contents, resulting in histopathologic injury and/or symptoms. With increasing understanding of gastroesophageal reflux disease, non-erosive...

...I.M. Modlin; G. Sachs; N. Wright; M. Kidd In 1905, John Edkins (1863–1940) undertook the studies of gastrin that have subsequently formed the basis for a century of investigation into the physiological basis of acid secretion and led to the elucidation of a variety of acid-suppressive...

...Yaron Niv; Britta Hardy; Rivka Koren; Galina Rodiomov; Gerald M. Fraser Background and Aims: The maintenance of an intact gastric mucosa implies a balance between aggressive, such as acid, and protective factors such as mucin. We examined gastric aspirates to determine a possible correlation...

... in the isolation and culture of pure strains circumvented a role for bacteria in gastric pathology. Furthermore, dogma and the intellectual chorus were in harmony advocating that gastric acid was critical in ulcer disease. The consideration of a role for a pathogen or pepsin was regarded as whimsical...