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Journal Articles

Akkermansia muciniphila and Its Extracellular Vesicles Affect Endocannabinoid System in in vitro Model

Subject Area:
Gastroenterology
Pegah Noori, Fattah Sotoodehnejadnematalahi, Pooneh Rahimi, Seyed Davar Siadat
Journal: Digestion
Digestion (2025)
https://doi.org/10.1159/000543446
Published Online: 13 March 2025
View article titled, Akkermansia muciniphila and Its Extracellular Vesicles Affect Endocannabinoid System in in vitro Model
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Journal Articles

Annual Trends in the Diagnosis of Autoimmune Gastritis Over 11 Years at a Single Facility in Japan

Subject Area:
Gastroenterology
Kaoru Nakano, Toshiaki Hirasawa, Ayaka Takasu, Yuka Higashi, Souya Nunobe, Masayuki Shimoda, Kengo Takeuchi, Hiroshi Kawachi
Journal: Digestion
Digestion (2025)
https://doi.org/10.1159/000544812
Published Online: 07 March 2025
View article titled, Annual Trends in the Diagnosis of Autoimmune Gastritis Over 11 Years at a Single Facility in Japan
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Journal Articles

Weakly supervised deep learning can analyze focal liver lesions in contrast-enhanced ultrasound

Subject Area:
Gastroenterology
Adil Oezsoy, James Alexander Brooks, Marko van Treeck, Yvonne Doerffel, Ulrike Morgera, Jens Berger, Marco Gustav, Oliver Lester Saldanha, Tom Luedde, Jakob Nikolas Kather, Tobias Paul Seraphin, Michael Kallenbach
Journal: Digestion
Digestion (2025)
https://doi.org/10.1159/000545098
Published Online: 06 March 2025
View article titled, Weakly supervised deep learning can analyze focal liver lesions in contrast-enhanced ultrasound
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Journal Articles

Xiayuxue Decoction plays an anti-development role in hepatocellular carcinoma through intestinal-hepatic axis

Subject Area:
Gastroenterology
Ting Zhou, Liyuan Pei, Ya Chen, Xuejing Wang, Hongyu Fang, Xiaoyan Zeng, Xuefei Tian
Journal: Digestion
Digestion (2025)
https://doi.org/10.1159/000543834
Published Online: 25 February 2025
View article titled, Xiayuxue Decoction plays an anti-development role in hepatocellular carcinoma through intestinal-hepatic axis
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Journal Articles

Endoscopic and Clinicopathological Features of a Colorectal Mucin-Rich Variant of Traditional Serrated Adenoma

Subject Area:
Gastroenterology
Eiji Kamba, Takashi Murakami, Naoki Tsugawa, Yudai Otsuki, Kei Nomura, Yuichiro Kadomatsu, Hirofumi Fukushima, Tsuyoshi Saito, Tomoyoshi Shibuya, Takashi Yao, Akihito Nagahara
Journal: Digestion
Digestion (2025)
https://doi.org/10.1159/000543700
Published Online: 21 February 2025
View article titled, Endoscopic and Clinicopathological Features of a Colorectal Mucin-Rich Variant of Traditional Serrated Adenoma
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Journal Articles

Impact of Helicobacter pylori on Immune Checkpoint Inhibition in Hepatocellular Carcinoma: A Multicenter Study

Subject Area:
Gastroenterology
Najib Ben Khaled, Christian Schulz, Marianna Alunni-Fabbroni, Kathrin Bronny, Leonie S. Jochheim, Behnam Kalali, Osman Öcal, Max Seidensticker, Ignazio Piseddu, Stefan Enssle, Monika Karin, Julia S. Schneider, Theresa Strasoldo-Graffemberg, Nadine Koch, Lukas Macke, Florian P. Reiter, Christian M. Lange, Yinghong Wang, Enrico N. De Toni, Markus Gerhard, Julia Mayerle, Jens Ricke, Peter Malfertheiner
Journal: Digestion
Digestion (2025)
https://doi.org/10.1159/000542847
Published Online: 19 February 2025
View article titled, Impact of Helicobacter pylori on Immune Checkpoint Inhibition in Hepatocellular Carcinoma: A Multicenter Study
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Journal Articles

Questionnaire Survey on the Diagnosis and Treatments of Eosinophilic Gastrointestinal Diseases in Asia

Subject Area:
Gastroenterology
Yoshikazu Tsuzuki, Akiko Shiotani, Kazuya Miyaguchi, Shouko Ono, Yutaka Saito, Mitsushige Sugimoto, Yuji Naito, Sachiyo Nomura, Osamu Handa, Tadakazu Hisamatsu, Mitsuhiro Fujishiro, Takahisa Matsuda, Yoshinori Morita, Naohisa Yahagi, Francis K.L. Chan, Tiing Leong Ang, Murdani Abdullah, Maria Carla Tablante, Varayu Prachayakul, Baiwen Li, Hwoon-Yong Jung, Hisashi Matsumoto, Rie Shiomi, Hiroyuki Imaeda
Journal: Digestion
Digestion 153–164.
https://doi.org/10.1159/000544725
Published Online: 13 February 2025
View article titled, Questionnaire Survey on the Diagnosis and Treatments of Eosinophilic Gastrointestinal Diseases in Asia
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Journal Articles

Dynamic Observation of Colonic Lesions, Commensal Microbiome, and Mycobiome Variations in Trinitrobenzene Sulfonic Acid-Induced Experimental Crohn’s Disease in Rats

Subject Area:
Gastroenterology
Mingjiang Liu, Huiwen Wang, Junjie Huang, Yuying Huai, Chenglong Yu, Guoqing Fang, Minxia Zhang, Ruonan Bo, Kai Fan, Jingui Li
Journal: Digestion
Digestion (2025)
https://doi.org/10.1159/000543337
Published Online: 11 February 2025
View article titled, Dynamic Observation of Colonic Lesions, Commensal Microbiome, and Mycobiome Variations in Trinitrobenzene Sulfonic Acid-Induced Experimental Crohn’s Disease in Rats
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Journal Articles

Endocuff Vision-Assisted Colonoscopy Significantly Improves Adenoma Detection in a Shorter Withdrawal Time Compared with Standard Colonoscopy: A Randomized Controlled Trial

Subject Area:
Gastroenterology
Duc Trong Quach, Thu Anh Nguyen, Mai Ngoc Luu, Uyen Pham-Phuong Vo, Vy Ly-Thao Tran, Truc Le-Thanh Tran, Tai Duy Nguyen, Nhan Quang Le, Toru Hiyama, Shinji Tanaka
Journal: Digestion
Digestion (2025)
https://doi.org/10.1159/000543630
Published Online: 17 January 2025
View article titled, Endocuff Vision-Assisted Colonoscopy Significantly Improves Adenoma Detection in a Shorter Withdrawal Time Compared with Standard Colonoscopy: A Randomized Controlled Trial
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Journal Articles

Cost-Effectiveness Analysis of Endoscopic Treatment versus Medication Strategy for Proton Pump Inhibitor-Refractory Gastroesophageal Reflux Disease

Subject Area:
Gastroenterology
Fumiaki Ishibashi, Sho Suzuki, Kentaro Mochida, Takao Tonishi, Yuichi Ishibashi
Journal: Digestion
Digestion (2024)
https://doi.org/10.1159/000543365
Published Online: 30 December 2024
View article titled, Cost-Effectiveness Analysis of Endoscopic Treatment versus Medication Strategy for Proton Pump Inhibitor-Refractory Gastroesophageal Reflux Disease
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Journal Articles

Deep Learning-Based Detection of Malignant Bile Duct Stenosis in Fluoroscopy Images of Endoscopic Retrograde Cholangiopancreatography

Subject Area:
Article Collection: Artificial Intelligence in Gastroenterology , Gastroenterology
Kien Vu Trung, Marcus Hollenbach, Gregory Patrick Veldhuizen, Oliver Lester Saldanha, Jakob Garbe, Jonas Rosendahl, Sebastian Krug, Patrick Michl, Jürgen Feisthammel, Thomas Karlas, Jochen Hampe, Albrecht Hoffmeister, Jakob Nikolas Kather
Journal: Digestion
Digestion (2024)
https://doi.org/10.1159/000543049
Published Online: 13 December 2024
View article titled, Deep Learning-Based Detection of Malignant Bile Duct Stenosis in Fluoroscopy Images of Endoscopic Retrograde Cholangiopancreatography
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Journal Articles

Effects of a Protease Inhibitor Camostat Mesilate on Gut Microbial Function in Patients with Irritable Bowel Syndrome: A Pilot Randomized Placebo-Controlled Study

Subject Area:
Gastroenterology
Motoyori Kanazawa, Kentaro Miyamoto, Michiko Kano, Kyoko Inooka, Kentaro Oka, Motomichi Takahashi, Nariyasu Mano, Shin Fukudo
Journal: Digestion
Digestion 1–12.
https://doi.org/10.1159/000542758
Published Online: 25 November 2024
View article titled, Effects of a Protease Inhibitor Camostat Mesilate on Gut Microbial Function in Patients with Irritable Bowel Syndrome: A Pilot Randomized Placebo-Controlled Study
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Journal Articles

DYRK2 regulates epithelial-mesenchymal transition restriction in pancreatic cancer liver metastasis by inhibiting Twist

Subject Area:
Gastroenterology
Hang Pan, Yin Liu, Kejiu Bao, Yulin Wang, Yuping Zhang, Lina Zhou
Journal: Digestion
Digestion 1–18.
https://doi.org/10.1159/000541039
Published Online: 19 November 2024
View article titled, DYRK2 regulates epithelial-mesenchymal transition restriction in pancreatic cancer liver metastasis by inhibiting Twist
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Journal Articles

Implementation of Machine Learning Algorithms to Screen for Advanced Liver Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: An In-Depth Explanatory Analysis

Subject Area:
Article Collection: Artificial Intelligence in Gastroenterology , Gastroenterology
Shoham Dabbah, Itamar Mishani, Yana Davidov, Ziv Ben Ari
Journal: Digestion
Digestion 1–14.
https://doi.org/10.1159/000542241
Published Online: 25 October 2024
View article titled, Implementation of Machine Learning Algorithms to Screen for Advanced Liver Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: An In-Depth Explanatory Analysis
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Journal Articles

Urgent Contrast-Enhanced Computed Tomography before Early Colonoscopy in the Management of Colonic Diverticular Bleeding: A Multicenter Randomized Controlled Trial

Subject Area:
Gastroenterology
Yuichiro Hirai, Toshio Uraoka, Michiko Wada, Hideki Mori, Ai Fujimoto, Yuko Sakakibara, Tatsuya Toyokawa, Takashi Kagaya, Yoshihiro Sasaki, Tomohiko Mannami, Toshio Kuwai, Noriko Watanabe, Hiroshige Hamada, Naoki Esaka, Toshihisa Kimura, Hiroyuki Fujii, Yasuo Hosoda, Masaaki Shimada, Hideharu Miyabayashi, Shinichi Somada, Katsuhiro Mabe, Shuji Inoue, Hiroki Saito, Kensuke Furuya, Norio Kawamura, Tomohiro Kudo, Keisuke Hori, Naoto Sakamoto, Mototsugu Kato, Nobuya Higuchi, Naohiko Harada, the NHO Network Gastrointestinal Study Group
Journal: Digestion
Digestion 1–13.
https://doi.org/10.1159/000541942
Published Online: 15 October 2024
View article titled, Urgent Contrast-Enhanced Computed Tomography before Early Colonoscopy in the Management of Colonic Diverticular Bleeding: A Multicenter Randomized Controlled Trial
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Journal Articles

NEIL3 Upregulated by TFAP2A Promotes M2 Polarization of Macrophages in Liver Cancer via the Mediation of Glutamine Metabolism

Subject Area:
Gastroenterology
Fabiao Zhang, Binfeng Wang, Wenlong Zhang, Yongfu Xu, Caiming Zhang, Xiangyang Xue
Journal: Digestion
Digestion (2025) 106 (1): 30–44.
https://doi.org/10.1159/000540804
Published Online: 27 September 2024
View article titled, NEIL3 Upregulated by TFAP2A Promotes M2 Polarization of Macrophages in Liver Cancer via the Mediation of Glutamine Metabolism
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Journal Articles

Efficacy and Safety of Etrasimod in Patients with Ulcerative Colitis in Japan: Data from the Phase 3 ELEVATE UC 12 and ELEVATE UC 40 JAPAN Trials

Subject Area:
Gastroenterology
Ken Takeuchi, Tadakazu Hisamatsu, Hiroshi Nakase, Katsuyoshi Matsuoka, Michael Keating, Hirotoshi Yuasa, Motoki Oe, Shoko Arai, Rafal Mazur, Toshifumi Hibi
Journal: Digestion
Digestion 1–9.
https://doi.org/10.1159/000541383
Published Online: 24 September 2024
View article titled, Efficacy and Safety of Etrasimod in Patients with Ulcerative Colitis in Japan: Data from the Phase 3 ELEVATE UC 12 and ELEVATE UC 40 JAPAN Trials
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Journal Articles

C-Kit Immunohistochemical Expression as a Complementary Method to Assess Mast Cell Density in Helicobacter pylori -Mediated Gastritis

Subject Area:
Gastroenterology
Ava T. Ismael, Rafal A. Abdulhameed, Bushra A. Hamdi, Rawaz D. Tawfeeq, Aram Ommar
Journal: Digestion
Digestion (2025) 106 (1): 23–29.
https://doi.org/10.1159/000541387
Published Online: 13 September 2024
View article titled, C-Kit Immunohistochemical Expression as a Complementary Method to Assess Mast Cell Density in Helicobacter pylori -Mediated Gastritis
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Journal Articles

Identification of a Novel Activated NK-Associated Gene Score Associated with Diagnosis and Biological Therapy Response in Ulcerative Colitis

Subject Area:
Gastroenterology
Siyuan Dong, Yu Zhang, Lingna Ye, Qian Cao
Journal: Digestion
Digestion (2025) 106 (1): 1–22.
https://doi.org/10.1159/000540939
Published Online: 23 August 2024
View article titled, Identification of a Novel Activated NK-Associated Gene Score Associated with Diagnosis and Biological Therapy Response in Ulcerative Colitis
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Journal Articles

Toll-Like Receptor 7-Expressed Macrophages Are Involved in the Pathogenesis of Esophageal Achalasia and Esophagogastric Junction Outflow Obstruction

Subject Area:
Gastroenterology
Masatoshi Kaizuka, Tetsuya Tatsuta, Shogo Kawaguchi, Tadashi Yoshizawa, Shukuko Yoshida, Tetsuyuki Tateda, Yohei Sawada, Shinji Ota, Shiro Hayamizu, Keisuke Hasui, Hidezumi Kikuchi, Hiroto Hiraga, Daisuke Chinda, Takahiro Muroya, Kenichi Hakamada, Hiroshi Kijima, Tatsuya Mikami, Shinsaku Fukuda, Hirotake Sakuraba
Journal: Digestion
Digestion (2024) 105 (6): 436–447.
https://doi.org/10.1159/000540693
Published Online: 05 August 2024
View article titled, Toll-Like Receptor 7-Expressed Macrophages Are Involved in the Pathogenesis of Esophageal Achalasia and Esophagogastric Junction Outflow Obstruction
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