Purpose: To investigate the safety and efficacy of an extract of Ziziphus jujuba for chronic constipation.Constipated patients received liquid Z. jujuba or placebo for 12 weeks. Subjects completed questionnaires, a visual analog scale and transit time (TT) tests before and after treatment. Results: Of 37 patients with a prolonged TT, 18 received the study drug and 19 a placebo. Two (12%) of the study and 16 (84%) of the control group dropped out due to severe constipation. The TT decreased from 12.2 particles for the study group to 3 particles at week 11. Symptom severity ratings decreased from 6 and 6.2 to 2 and 5, and the quality of life score improved from 1.9 and 2.3 to 1.3 and 1.4 in the study and control groups, respectively. Conclusion:Z. jujuba extract is an effective and safe treatment for chronic constipation.

Ramkumar D, Rao SS: Efficacy and safety of traditional medical therapies for chronic constipation: systematic review. Am J Gastroenterol 2005;100:936–971.
Complementary and Alternative Healing University: The Chinese Herb Dictionary da zao page. http://alternativehealing.org/da_zao.htm (accessed Sept 13, 2006).
Huang KG: The Pharmacology of Chinese Herbs, ed 2. Boca Raton, CRC Press, 1999, pp 155–156.
McHorney CA, Ware JE Jr, Raczek AE: The MOS 36-Item Short-Form Health Survey (SF-36). II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care 1993;31:247–263.
Lennard-Jones JE: Transit studies; in Kamm MA, Lennard-Jones JE (eds): Constipation. Petersfield/UK, Wrightson Biomedical Publishing, 1994, pp 125–136.
Loening-Baucke V, Pashankar DS: A randomized, prospective, comparison study of polyethylene glycol 3350 without electrolytes and milk of magnesia for children with constipation and fecal incontinence. Pediatrics 2006;118:528–535.
Migeon-Duballet I, Chabin M, Gautier A, Bonnet M, Aubert JM, Halphen M: Long-term efficacy and cost-effectiveness of polyethylene glycol 3350 plus electrolytes in chronic constipation: a retrospective study in a disabled population. Curr Med Res Opin 2006;22:1227–1235.
Kamm MA, Muller-Lissner S, Talley NJ, Tack J, Boeckxstaens G, Minushkin ON, Kalinin A, Dzieniszewski J, Haeck P, Fordham F, Hugot-Cournez S, Nault B: Tegaserod for the treatment of chronic constipation: a randomized, double-blind, placebo-controlled multinational study. Am J Gastroenterol 2005;100:362–372.
Lederle FA, Busch DL, Mattox KM, West MJ, Aske DM: Cost-effective treatment of constipation in the elderly: a randomized double-blind comparison of sorbitol and lactulose. Am JMed 1990;89:597–601.
Rouse M, Chapman N, Mahapatra M, Grillage M, Atkinson SN, Prescott P: An open, randomized, parallel group study of lactulose versus ispaghula in the treatment of chronic constipation in adults. Br J Clin Pract 1991;45:28–30.
Quah HM, Ooi BS, Seow-Choen F, Sng KK, Ho KS: Prospective randomized crossover trial comparing fiber with lactulose in the treatment of idiopathic chronic constipation. Tech Coloproctol 2006;10:111–114.
Jailwala J, Imperiale TF, Kroenke K: Pharmacologic treatment of the irritable bowel syndrome: a systematic review of randomized, controlled trials. Ann Intern Med 2000;133:136–147.
Rao SS, Ozturk R, Laine L: Clinical utility of diagnostic tests for constipation in adults: a systematic review. Am J Gastroenterol 2005;100:1605–1615.
Muller-Lissner SA, Kamm MA, Scarpignato C, Wald A: Myths and misconceptions about chronic constipation. Am J Gastroenterol 2005;100:232–242.
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