Abstract
The high prevalence of gastroesophageal reflux disease (GERD) in Western societies has accelerated the need for new modalities of treatment. Currently, medical and surgical therapies are widely accepted among patients and physicians. The minimally invasive treatment revolution, however, has stimulated several new endoscopic techniques for GERD. Up to now, the data is limited and further studies are necessary to compare the advantages and disadvantages of the various endoscopic techniques to medical and laparoscopic management of GERD. This systematic review reports the efficacy and durability of various endoscopic therapies for GERD whilst the potential for widespread use of these techniques is also discussed. Despite the limited number of studies and remarkable differences between various trials, strict criteria were used for the pooled data presented and an effort was made to avoid bias by including only studies that used off-antisecretory medication scoring as baseline and intent to treat.
Journal Section:
Review
References
1.
Locke GR, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ 3rd: Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology 1997;112:1448–1456.
[PubMed]
2.
DiBaise JK: And then there were three – endotherapy for gastroesophageal reflux disease. Am J Gastroenterol 2003;98:1909–1912.
[PubMed]
3.
DeMeester TR, Peters JH, Bremner CG, Chandrasoma P: Biology of gastro-esophageal reflux disease: pathophysiology relating to medical and surgical treatment. Annu Rev Med 1999;50:469–506.
[PubMed]
4.
Tack J: Recent developments in the pathophysiology and therapy of gastroesophageal reflux disease and nonerosive reflux disease. Curr Opin Gastroenterol Rep 2005;21:454–460.
[PubMed]
5.
Straathof JW, Ringers J, Lamers CB, Masclee AA: Provocation of transient lower esophageal sphincter relaxations by gastric distension with air. Am J Gastroenterol 2001;96:2317–2323.
[PubMed]
6.
Massey BT: Potential control of gastroesophageal reflux by local modulation of transient lower esophageal sphincter relaxations. Am J Med 2001;3:186S–9S.
7.
Hirsch DP, Mathus-Vliegen EM, Dagli U, Tytgat GN, Boeckxstaens GE: Effect of prolonged gastric distention on lower esophageal sphincter function and gastroesophageal reflux. Am J Gastroenterol 2003;98:1696–1704.
[PubMed]
8.
Kahrilas PJ: GERD pathogenesis, pathophysiology and clinical manifestations. Cleve Clin J Med 2003;70(suppl):S4–S19.
9.
Kahrilas PJ: Radiofrequency therapy of the lower esophageal sphincter for the treatment of GERD. Gastrointest Endosc 2003;57:723–731.
[PubMed]
10.
DeVault KR, Castell DO: Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol 2005;100:190–200.
[PubMed]
11.
Fuchs KH, Freys SM: Endoscopic antireflux therapy. Surg Endosc 2003;17:1009–1016.
[PubMed]
12.
Mason RJ, Filipi CJ, DeMeester TR, Peters JH, Lund RJ, Flake AW, Hinder RA, Smyrk TC, Bremner CG, Thompson S: A new intraluminal antigastroesophageal reflux procedure in baboons. Gastrointest Endosc 1997;45:283–290.
[PubMed]
13.
Kadirkamanathan SS, Evans DF, Gong F, Yazaki E, Scott M, Swain CP: Antireflux operations at flexible endoscopy using endoluminal switching techniques: an experimental study. Gastrointest Endosc 1996;44:133–143.
[PubMed]
14.
Horatogis A, Hieston K, Lehman G: Evaluation of supplemental cautery during endoluminal gastroplication for treatment of gastroesophageal reflux disease. DDW 2003.
15.
Feitoza AB, Gostout CJ, Rajan E, Smoot RL, Burgart LJ, Schleck C, Zinsmeister AR: Understanding endoluminal gastroplications: a histopathologic analysis of intraluminal suture plications. Gastrointest Endosc 2003;57:868–876.
[PubMed]
16.
Liu JJ, Glickman JN, Carr-Locke DL, Brooks DC, Saltzman JR: Gastroesophageal junction smooth muscle remodeling after endoluminal gastroplication. Am J Gastroenterol 2004;99:1895–1901.
[PubMed]
17.
Filipi CJ, Lehman GA, Rothstein RI, Raijman I, Stiegmann GV, Waring JP, Hunter JG, Gostout CJ, Edmundowicz SA, Dunne DP, Watson PA, Cornet DA: Transoral, flexible endoscopic suturing for treatment of GERD: a multicenter trial. Gastrointest Endosc 2001;53:416–422.
[PubMed]
18.
Chen YK, Raijman I, Ben-Menachem T, Starpoli AA, Liu J, Pazwash H, Weiland S, Shahrier M, Fortajada E, Saltzman JR, Carr-Locke DL: Long-term outcomes of endoluminal gastroplication: a US multicenter trial. Gastrointest Endosc 2005;61:659–667.
[PubMed]
19.
Rothstein RI, Hynes ML, Grove MR, Pohl H: Endoscopic gastric plication for GERD: a randomized, sham-controlled, blinded, single-center study. Gastrointest Endosc 2004;59:AB111.
20.
Mahmood Z, McMahon BP, Arfin Q, Byrne PJ, Reynolds JV, Murphy EM, Weir DG: EndoCinch therapy for gastro-oesophageal reflux disease: a one-year prospective follow-up. Gut 2003;52:34–39.
[PubMed]
21.
Tam WCE, Holloway RH, Dent J, Rigda R, Schoeman MN: Impact of endoscopic suturing of the gastroesophageal junction on lower esophageal sphincter function and gastroesophageal reflux in patients with reflux disease. Am J Gastroenterol 2004;99:195–202.
[PubMed]
22.
Martinez-Serna T, Davis RE, Mason R, Perdikis G, Filipi CJ, Lehman G, Nigro J, Watson P: Endoscopic valvuloplasty for GERD. Gastrointest Endosc 2000;52:663–670.
[PubMed]
23.
Liu JL, Knapp R, Silk J, Carr-Locke DL: Treatment of medication refractory gastroesophageal reflux disease with endoluminal gastroplication. Gastrointest Endosc 2002;55:AB257.
24.
Hong D, Swanstrom L: Endoscopic plication as salvage procedure for failed surgical fundoplications in select patients. Surg Endosc Suppl 2004;S222.
25.
Pazwash H, Gualtieri NM, Starpoli A: Failed surgical fundoplication: a possible new indication for endoluminal gastroplication. Am J Gastroenterol 2002;97(S212):AB646.
26.
Davis Filipi CJ, Gerhardt J: Comparison of endoluminal gastroplication configuration techniques. Am J Gastroenterol 2002;97:S30.
27.
Raijman I, Walters R, Garza C, Spano C: Helical endoluminal gastroplication (ELGP) compared to standard ELGP in patients with gastroesophageal reflux disease. Gastrointest Endosc 2002;55:AB260.
28.
Liu JJ, Knapp RM, Saltzman JR, Osterman MT, Carr-Locke DL: Impact of anesthesiologist on endoluminal gastroplication procedure. Am J Gastroenterol 2002;97:S306.
29.
Velanovich V, Ben Menachem T: Laparoscopic Nissen fundoplication after failed endoscopic gastroplication. J Laparoendosc Adv Surg Tech A 2002;12:305–308.
[PubMed]
30.
Heider M, Iqbal A, Filipi CJ: Endoluminal gastroplasty: a new treatment for gastroesophageal reflux disease. Thorac Surg Clin 2005;15:385–394.
31.
Ben-Menachem T, Chen Y, Raijman I, Starpoli A, Pazwash H, Liu J, Carr-Locke D: Symptom recurrence after endoluminal gastroplication for GERD: comparison of initial versus repeat ELGP. Gastrointest Endosc 2003;57:AB130.
32.
Mahmood Z, Byrne PJ, McCullouch J, Arfin Q, McMahon B, Murphy E, Reynolds JV, Weir DG: A comparison of Bard EndoCinch transoesophageal endoscopic plication with laparoscopic Nissen fundoplication for the treatment of gastroesophageal reflux disease. Gastrointest Endosc 2002;55:AB463.
33.
Chadalavada R, Lin E, Swafford V, Sedghi S, Smith CD: Comparative results of endoluminal gastroplasty and laparoscopic antireflux surgery for the treatment of GERD. Surg Endosc 2004;18:261–265.
[PubMed]
34.
Velanovich V, Ben-Menachem T, Goel S: Case-control comparison of endoscopic gastroplication with laparoscopic fundoplication in the treatment of gastroesophageal reflux disease. Surg Laparosc Endosc Percutan Tech 2002;12:219–223.
[PubMed]
35.
Pleskow D, Rothstein R, Lo S, Hawes R, Kozarek R, Haber G, Gostout C, Lembo A: Endoscopic full-thickness plication for the treatment of GERD: a multicenter trial. Gastrointest Endosc 2004;59:163–171.
[PubMed]
36.
Pleskow D, Rothstein R, Lo S, Hawes R, Kozarek R, Haber G, Gostout C, Lembo A: Endoscopic full-thickness plication for GERD: 12-month follow-up for the North American open-label trial. Gastrointest Endosc 2005;61:643–649.
[PubMed]
37.
Chuttani R, Sud R, Sachdev G, Puri R, Kozarek R, Haber G, Pleskow D, Zaman M, Lembo A: A novel endoscopic full-thickness plicator for the treatment of GERD: a pilot study. Gastrointest Endosc 2003;58:770–776.
[PubMed]
38.
Utley DS, Kim M, Vierra MA, Triadafilopoulos G: Augmentation of the lower esophageal sphincter pressure and gastric yield pressure after radiofrequency energy delivery to the lower esophageal sphincter muscle; a porcine model. Gastrointest Endosc 2000;52:81–86.
[PubMed]
39.
Richards WO, Houston HL, Torquati A, Khaitan L, Holzman MD, Sharp KW: Paradigm shift in the management of gastroesophageal reflux disease. Ann Surg 2003;237:638–647.
[PubMed]
40.
McClusky D, Khaitan L, Gonzalez R, et al: A comparison between standard technique and fluoroscopically guided radiofrequency energy delivery in the treatment of fundoplication disruption. SAGES, 2004, p 85.
41.
Go MR, Dundon JM, Karlowicz DJ, Domingo CB, Muscarella P, Melvin WS: Delivery of radiofrequency energy to the lower esophageal sphincter improves symptoms of gastroesophageal reflux. Surgery 2004;136:786–794.
[PubMed]
42.
Noar M, Knight S, Bidlack D, Towson A: A modified technique for endoluminal delivery of radiofrequency energy for the treatment of GERD in patients with failed fundoplication or large hiatal hernia. Gastrointest Endosc 2002;55:AB258.
43.
Kim MS, Holloway RH, Dent J, Utley DS: Radiofrequency energy delivery to the gastric cardia inhibits triggering of transient lower esophageal sphincter relaxation and gastroesophageal reflux in dogs. Gastrointest Endosc 2003;57:17–22.
[PubMed]
44.
DiBaise JK, Brand RE, Quigley EM: Endoluminal delivery of radiofrequency energy to the gastroesophageal junction in uncomplicated GERD: efficacy and potential mechanism of action. Am J Gastroenterol 2002;97:833–842.
[PubMed]
45.
Triadafilopoulos G, DiBaise JK, Nostrant TT, Stollman NH, Anderson PK, Wolfe MM, Rothstein RI, Wo JM, Corley DA, Patti MG, Antignano LV, Goff JS, Edmundowicz SA, Castell DO, Rabine JC, Kim MS, Utley DS: The Stretta procedure for the treatment of GERD: 6- and 12-month follow-up of the US open label trial. Gastrointest Endosc 2002;55:149–156.
[PubMed]
46.
Corley DA, Katz P, Wo JM, Stefan A, Patti M, Rothstein R, Edmundowicz S, Kline M, Mason R, Wolfe MM: Improvement of gastroesophageal reflux symptoms after radiofrequency energy: a randomized, sham-controlled trial. Gastroenterology 2003;125:668–676.
[PubMed]
47.
Triadafilopoulos G, DiBaise JK, Nostrant TT, Stollman NH, Anderson PK, Edmundowicz SA, Castell DO, Kim MS, Rabine JC, Utley DS: Radiofrequency energy delivery to the gastroesophageal junction for the treatment of GERD. Gastrointest Endosc 2001;53:407–415.
[PubMed]
48.
Wolfsen HC, Richards WO: The Stretta procedure for the treatment of GERD: a registry of 558 patients. J Laparoendosc Adv Surg Tech A 2002;12:395–402.
[PubMed]
49.
Torquati A, Houston HL, Kaiser J, Holzman MD, Richards WO: Long-term follow-up study of the Stretta procedure for the treatment of gastroesophageal reflux disease. Surg Endosc 2004;18:1475–1479.
[PubMed]
50.
Reymunde A, Santiage N: The Stretta procedure is effective at 3+ year follow-up for improving GERD symptoms and eliminating the requirement for anti-secretory drugs. Am J Gastroenterol 2004;99:S29.
51.
Houston H, Khaitan L, Holzman M, Richards WO: First year experience of patients undergoing the Stretta procedure. Surg Endosc 2003;17:401–404.
[PubMed]
52.
Mason RJ, Hughes M, Lehman GA, Chiao G, Deviere J, Silverman DE, DeMeester TR, Peters JH: Endoscopic augmentation of the cardia with a biocompatible injectable polymer (Enteryx) in a porcine model. Surg Endosc 2002;16:386–391.
[PubMed]
53.
Felsher J, Farres H, Chand B, Farver C, Ponsky J: Mucosal apposition in endoscopic suturing. Gastrointest Endosc 2003;58:867–870.
[PubMed]
54.
Tam WCE, Schoeman MN, Zhang Q, Dent J, Rigda R, Utley D, Holloway RH: Delivery of radiofrequency energy to the lower oesophageal sphincter and gastric cardia inhibits transient lower oesophageal sphincter relaxations and gastro-oesophageal reflux in patients with reflux disease. Gut 2003;52:479–485.
[PubMed]
55.
Noar M, Lofti S, Towson A: Radiofrequency energy ablation of the cardia and esophagogastric junction corrects GERD-associated gastroparesis. Gastrointest Endosc 2003;57:AB675.
56.
Liu JJ, Carr-Locke DL, Lee LS, Brooks DC, Saltzman JR: Endoluminal gastroplication for treatment of patients with classic gastroesophageal reflux symptoms and borderline 24-hour pH studies. Scand J Gastroenterol 2004;39:615–620.
[PubMed]
57.
Rothstein RI, Filipi CJ: Endoscopic suturing for gastroesophageal reflux disease: clinical outcome with the Bard EndoCinch. Gastrointest Endosc Clin N Am 2003;13:89–101.
[PubMed]
58.
Caca K, Schiefke I, Söder H, Neumann S, Zabel-Langhenning A, Mössner J: Endoluminal gastroplication for gastroesophageal reflux disease. Gastrointest Endosc 2002;55:M1888.
59.
Noar M, Smith J: The Stretta procedure improves GERD symptoms and anti-secretory drug use at 2 years, while normalizing gastric emptying function in the majority of impaired subjects. Gastrointest Endosc 2004;59:W1514.
60.
Swain P, Park PO, Kjellin T, Gong F, Kadirkamanathan S, Appleyard M: Endoscopic gastroplasty for gastroesophageal reflux disease. Gastrointest Endosc 2000;51:AB4470.
61.
Wiersema MJ, Levy MJ: Cost analysis of endoscopic antireflux procedures: endoluminal plication vs. radiofrequency coagulation vs. treatment with a proton pump inhibitor. Gastrointest Endosc 2004;59:749–750.
[PubMed]
62.
Spechler SJ, Lee E, Ahnen D, Goyal RK, Hirano I, Ramirez F, Raufman JP, Sampliner R, Schnell T, Sontag S, Vlahcevic ZR, Young R, Williford W: Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease: follow-up of a randomized controlled trial. JAMA 2001;121:1286–1293.
63.
Chang KJ, Nguyen NT, Pandolfino JE, Nguyen PT: Endoluminal plication with mucosal ablation of the Gastroesophageal junction (GEJ) does not improve LES pressure, gastric yield pressure or GEJ compliance: is it time to give up? Gastrointest Endosc 2005;61:AB129.
64.
Lepoutre E, Boyer J, Grimaud JC, Letard JC, Escourrou J, Prat F, Ducrotte P, Canard JM, Rey JF, Ponchon T: Endoscopic suturing for GERD: results at one year precludes the use of routine practice. Gastrointest Endosc 2005;61:AB136.
65.
Abou-Rebyeh H, Hoepffner N, Rosch T, Osmanoglou E, Haneke JH, Hintze RE, Wiedenmann B, Monnikes H: Long-term failure of endoscopic suturing in the treatment of gastroesophageal reflux: a prospective follow-up study. Endoscopy 2005;35:213–216.
66.
Schiefke I, Zabel-Langhennig A, Neumann S, Feisthammel J, Moessner J, Caca K: Long-term failure of endoscopic gastroplication (EndoCinch). Gut 2005;54:752–758.
[PubMed]
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