Abstract
Crohn’s disease is often complicated by gastrointestinal strictures. Postoperative recurrence at the anastomotic site is common and repeated surgical interventions may be necessary. Medical treatment may relieve active inflammation (see chapter on active luminal disease) but fibrous strictures will not respond to this. Mechanical treatment methods consist of endoscopic balloon dilation, stricturoplasty or surgical resection. Fibrostenotic Crohn’s disease does not respond to medical therapy and requires endoscopic or surgical treatment.
Journal Section:
Review
References
1.
Legnani PE, Kornbluth A: Therapeutic options in the management of strictures in Crohn’s disease. Gastrointest Endosc Clin N Am 2002;12:589–603.
[PubMed]
2.
Sandborn WJ, et al: A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn’s disease. Gastroenterology 2002;122:512–530.
[PubMed]
3.
Sands BE: Crohn’s Disease. Sleisenger and Fordtran’s Gastrointestinal and Liver Disease, ed 7. New York, Elsevier, 2002, pp 2005–2038.
4.
Fazio VW, et al: Effect of resection margins on the recurrence of Crohn’s disease in the small bowel. A randomized controlled trial. Ann Surg 1996;224:563–573.
[PubMed]
5.
Thirlby RC, et al: Effect of surgery on health-related quality of life in patients with inflammatory bowel disease: A prospective study. Arch Surg 1998;133:826–832.
[PubMed]
6.
Fazio VW, et al: Long-term follow-up of strictureplasty in Crohn’s disease. Dis Colon Rectum 1993;36:355–361.
[PubMed]
7.
Dietz DW, et al: Safety and long-term efficacy of strictureplasty in 314 patients with obstructing small bowel Crohn’s disease. J Am Coll Surg 2001;192:330–338.
[PubMed]
8.
Sayfan J, et al: Recurrence after strictureplasty or resection for Crohn’s disease. Br J Surg 1989;76:335–338.
[PubMed]
9.
Cristaldi M, et al: Long-term results and multivariate analysis of prognostic factors in 138 consecutive patients operated on for Crohn’s disease using ‘bowel-sparing’ techniques. Am J Surg 2000;179:266–270.
[PubMed]
10.
Couckuyt H, et al: Efficacy and safety of hydrostatic balloon dilatation of ileocolonic Crohn’s strictures: A prospective long-term analysis. Gut 1995;36:577–580.
[PubMed]
11.
Dear KL, Hunter JO: Colonoscopic hydrostatic balloon dilatation of Crohn’s strictures. J Clin Gastroenterol 2001;33:315–318.
[PubMed]
12.
Thomas-Gibson S, et al: Colonoscopic balloon dilation of Crohn’s strictures: A review of long-term outcomes. Eur J Gastroenterol Hepatol 2003;15:485–488.
[PubMed]
© 2005 S. Karger AG, Basel
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2005
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