It is important to study the effect of Helicobacter pylori infection on the permeability of the intestine. Permeability was evaluated by oral sucrose tolerance test using sucrose 25 g in 200 ml of water. Existence of H. pylori itself was associated with increased permeability of sucrose. Also, the permeability of sucrose increased as polymorphonuclear and lymphocyte infiltration increased. The increase of mucosal permeability suggests that antigens like protein penetrate into the body and result in systemic reactions. Thus, it is important to study the implication of increased permeability in relation not only to gastric diseases but also certain systemic diseases.

Marshall BJ, Armstrong JA, McGechie DB, Glacy RJ: Attempt to fulfil Koch’s postulates for pyloric Campylobacter. Med J Aust 1985;142:436–439.
Fukuda Y, Yamamoto I, Tonokatsu Y, Tamura K, Shimoyama T: Inoculation of rhesus monkeys with human Helicobacter pylori: A long-term investigation on gastric mucosa by endoscopy. Dig Endosc 1992;4:19–30.
Graham DY: Pathogenic mechanisms leading to Helicobacter pylori-induced inflammation. Eur J Gastroenterol Hepatol 1992;4(suppl 2):9–16.
Sawada Y, Yamamoto N, Sakagami T, Fukuda Y, Shimoyama T, Nishigami T, Uematsu K, Nakagawa K: Comparison of pathologic changes in Helicobacter pylori-infected Mongolian gerbils and humans. J Gastroenterol 1999;34(suppl 11):55–60.
Sipponen P, Hyaline H: Role of Helicobacter pylori in the pathogenesis of gastritis, peptic ulcer and gastric cancer. Scand J Gastroenterol 1993;28(suppl 196):3–6.
Graham DY, Lew GM, Klein PD, Evans DJ Jr, Saeed ZA, Malaty HM: Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric and duodenal ulcer. A randomized controlled study. Ann Intern Med 1992;116:705–708.
Yamamoto N, Sakagami T, Fukuda Y, Koizuka H, Hori K, Sawada Y, Hikasa Y, Tanida N, Shimoyama T: Influence of Helicobacter pylori infection on development of stress-induced gastric mucosal injury. J Gastroenterol 2000;35:332–340.
The Eurogast Study Group: An international association between Helicobacter pylori infection and gastric cancer. Lancet 1993;341:1359–1362.
Nomura A, Stemmerman GN: Helicobacter pylori and gastric cancer. J Gastroenterol Hepatol 1993;8:294–303.
Parsonnet J: Helicobacter pylori and gastric cancer. Gastroenterol Clin N Am 1993:32:89–104.
Watanabe T, Tada M, Nagai H, Sasaki S, Nakao M: Helicobacter pylori infection induces gastric cancer in Mongolian gerbils. Gastroenterology 1998;115:642–648.
Posalaky Z, Posalaki I, McGinley D, Meyer R: The gastric mucosal barrier: Tight junction structure in gastritis and ulcer biopsies. Virchow Arch 1989;414:217–222.
Chaloupka JC, Gay BB Jr, Caplan D: Campylobacter gastritis simulating Menetrier’s disease by upper gastrointestinal radiography. Pediatr Radiol 1990;20:200–201.
Salmeron M, Desplaces N, Lavergne A, Houdart R: Campylobacter pylori hypertrophic erosive gastritis and hyperalbuminemia healed by cephalexin. Gastroenterol Clin Biol 1989;13:109–110.
Bayerdorfer E, Ritter MM, Hatz R, Brooks W, Stolte M: Menetrier’s disease and Helicobacter pylori. N Engl J Med 1993;329:60.
Di Campli C, Gasbarrini A, Nucera E, Franceschi F, Ojetti V, Sanz Torre E, Schiavino D, Pola P, Patriarca G, Gasbarrini G: Beneficial effects of Helicobacter pylori eradication on idiopathic chronic urticaria. Dig Dis Sci 1998;43:1226–1229.
Gasbarrini A, De Luca A, Fiore G, Gambrielli M, Franceschi F, Ojetti V, Torre ES, Gasbarrini G, Pola P, Giacovazzo M: Beneficial effects of Helicobacter pylori eradication on migraine. Hepatogastroenterology 1998;45:765–770.
Murakami K, Fujioka T, Nishizono A, Nagai J, Tokieda M, Kodama R, Kubota T, Nasu M: Atopic dermatitis successfully treated by eradication of Helicobacter pylori. J Gastroenterol 1996;31(suppl 9):77–82.
Meddings JB, Sutherland LR, Byles NI, Wallace JL: Sucrose: A novel permeability marker for gastroduodenal disease. Gastroenterology 1993;104:1619–1626.
Rabassa AA, Goodgame R, Sutton FM, Ou CN, Rognerud C, Graham DY: Effects of aspirin and Helicobacter pylori on the gastroduodenal mucosal permeability to sucrose. Gut 1996;39:159–163.
Sutherland L, Verhoef M, Wallace J, Van Rosendaal G, Crutcher R, Meddings J: A simple, noninvasive marker of gastric damage: Sucrose permeability. Lancet 1994;343:998–1000.
Vera JF, Gotteland M, Chavez E, Vial MT, Kararieka E, Brunster O: Sucrose permeability in children with gastric damage and Helicobacter pylori infection. J Pediatr Gastroenterol Nutr 1997;24:506–511.
Goodgame RW, Malaty HM, el-Zimaity HM, Graham DY: Decrease in gastric permeability to sucrose following cure of Helicobacter pylori infection. Helicobacter 1997;2:44–47.
Borch K, Sjostedt C, Hannestad U, Soderholm JD, Franzen L, Mardh S: Asymptomatic Helicobacter pylori gastritis is associated with increased sucrose permeability. Dig Dis Sci 1998;43:749–753.
Papini F, Satin B, Norais N, de Bernard M, Telford JL, Rappuoli R, Montecucco C: Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin. J Clin Invest 1998;15:813–820.
Price AB: The Sydney system: Histologic division. J Gastroenterol Hepatol 1991;6:209–222.
Sundqvist T, Magnusson KE, Sjodahl R, Stjernstrom I, Agesson C: Passage of molecules through the wall of the gastrointestinal tract. II. Application of low-molecular weight polyethylene glycol and a deterministic mathematical model for determining intestinal permeability in man. Gut 1980;21:208–214.
Ukabam SO, Clamp JR, Cooper BT: Abnormal small intestinal permeability to sugars in patients with Crohn’s disease of the terminal ileum and colon. Digestion 1983;27:70–74.
Strobel S, Brydon WD, Ferguson A: Cellobiose/mannitol sugar permeability test complements biopsy histopathology in clinical investigation of the jejunum. Gut 1984;25:1241–1246.
Sanderson IR, Boulton P, Menzies I, Walker-Smith JA: Improvement of abnormal lactulose/rhamnose permeability in active Crohn’s disease of the small bowel by an elemental diet. Gut 1987;28:1073–1076.
You do not currently have access to this content.