Purpose: To study the effect of pharyngeal and esophageal distension on the pressure within the stomach aiming at assessing the stomach condition during passage of food boli through the pharynx and esophagus. Methods: 12 dogs (mean weight 16.2 ± 3.3 kg) were studied. With the animal under anesthesia, a 4-Fr manometric catheter was introduced into the stomach and a 2-Fr balloon-tipped catheter into the pharynx. The gastric pressure response to pharyngeal and esophageal distension, each at a time, was recorded. Distension was performed in increments of 2 ml of water up to 6 ml. The test was repeated while the pharynx, esophagus or stomach were separately anesthetized using 2% xylocaine. Bilateral truncal vagotomy was done in 4 dogs and the gastric response to pharyngoesophageal distension studied. Results: Pharyngeal distension produced a significant pressure drop of the corpus of the stomach (p < 0.05); the pyloric antrum showed no response. Upper, middle or lower esophageal distension produced gastric response similar to that evoked by pharyngeal distension. The gastric response was abolished on distension of the anesthetized pharynx or esophagus, when the corpus was anesthetized, or after bilateral vagotomy. Conclusion: The proximal gastric dilatation on pharyngeal and esophageal distension postulates a reflex relationship between the two actions which we call ‘pharyngoesophagogastric reflex’. This reflex is suggested to dilate the proximal stomach preparatory to receiving food boli from the esophagus; it was abolished after anesthetizing its possible two arms arising from the pharyngoesophagus and the stomach, or after vagotomy.

Journal Section:
Original Paper: Oesophagus
Keywords:
Pharynx, Deglutition, Esophagus, Swallowing, Reflex, Stomach, Pyloric antrum
1.
Miller AJ: Deglutition. Physiol Rev 1982;62:129&ndash;134.
[PubMed]
2.
Collman PI, Tremblay L, Diamant NE: The distribution of spinal and vagal sensory neurons that innervate the esophagus of the cat. Gastroenterology 1992;103:817&ndash;822.
[PubMed]
3.
Shafik A: Esophago-sphincter inhibitory reflex: Role in the deglutition mechanism and esophageal achalasia. J Invest Surg 1996;9:37&ndash;44.
[PubMed]
4.
Undekwu AO: Gastrointestinal physiology; in Simmons RL, Steed DL (eds): Basic Science Review for Surgeons. Philadelphia, Saunders, 1992, pp 229&ndash;231.
5.
Cook IJ, Dodds WJ, Dantas RO: Timing of videofluoroscopic manometric events and bolus transport during the oral and pharyngeal phases of swallowing. Dysphagia 1989;4:8&ndash;15.
[PubMed]
6.
Schoen HI, Morris DW, Cohen S: Esophageal peristaltic force in man. Response to mechanical and pharmacologic alterations. Am J Dig Dis 1977;22:589-597.
[PubMed]
7.
Hamlet SL, Muz J, Patterson R, Jones L: Pharyngeal transit time: Assessment with videofluoroscopic and scintigraphic techniques. Dysphagia 1989;4:4&ndash;7.
[PubMed]
8.
Shafik A: Recognition of a pharyngo-oesophageal sphincter inhibitory reflex in dogs and its role in deglutition. Exp Physiol 1995;80:249&ndash;253.
[PubMed]
9.
The Guide for Care and Use of Laboratory Animals. US Public Health Services NIH Publ No 1989;1:5&ndash;23.
10.
Bullock J, Boyle J, Wang MB: Stomach; in Bullock J, Boyle J, Wang MB (eds): Physiology, ed 3. Philadelphia, Williams &amp; Wilkins, 1995, pp 422&ndash;432.
11.
Kellow JE: Gastrointestinal motility and defecation; in Greger R, Windhorst U (eds): Comprehensive Human Physiology: From Cellular Mechanisms to Integration. Heidelberg, Springer, 1996, pp 1289&ndash;1308.
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1999
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