A review of the progress in pharmacological treatment of portal hypertension is best considered in the clinical setting of the acute variceal bleeding episode, the primary prophylaxis of variceal bleeding, and prevention of rebleeding from varices and portal hypertensive gastropathy. The data from randomized trials has been evaluated using meta-analysis when possible, and a conclusion made regarding the optimal drug or other therapy in the particular clinical setting. A recent meta-analytic review has been published [1].

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