In contrast to its effect in animal experiments, biguanide is shown to have no effect on gastric emptying in man. Gastric emptying was assessed by the double sampling test meal 2 h after placebo or 1 g of dimethylbiguanide (Metformin). The test meal consisted of 750 ml of water, either pure or containing 50 or 100 g of glucose. The data confirm that osmolality prevents gastric emptying of water and demonstrate that Metformin does notinfluence this emptying.

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