The effects of cimetidine on gastric mucus glycoprotein biosynthesis in rat gastric mucosa were investigated using organ culture technique. 2 h following oral administration of cimetidine (40 mg/kg body weight), corpus tissue was placed in the organ culture. Mucus glycoprotein synthesis was accelerated to 137% of control (p < 0.01). In order to investigate the direct effect of cimetidine on mucus glycoprotein biosynthesis, corpus tissue was cultured in the medium containing cimetidine. 100 μM cimetidine enhanced mucus glycoprotein biosynthesis to 174% (p < 0.01). Cimetidine was found to stimulate gastric mucus glycoprotein biosynthesis both in vivo and in vitro.

Journal Section:
Original Paper
Keywords:
Gastric mucus glycoprotein, Mucus glycoprotein biosynthesis, Cimetidine, Organ culture
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© 1986 S. Karger AG, Basel
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1986
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