The aim of this study was to identify the somatostatin (SST-14) dose dissolved in 0.1 % human albumin solution equivalent to the commonly used therapeutic dose (3.5 μg kg-1 h-1) dissolved in saline in inhibiting pentagastrin-stimulated gastric acid secretion in healthy volunteers. Gastric acid secretion was stimulated for 3.5 h by intravenous pentagastrin (3 μg kg-1 h-1). 0.875 or 1.75 μg kg-1 h-1 SST-14 dissolved in 0.1 % albumin was significantly (p < 0.05) less effective in inhibiting stimulated gastric acid secretion than the standard therapeutic dose. There was no difference achieved in the degree of inhibition with albumin added or not to the 3.5 μg kg-1 h-1 dose of SST-14. However, an intermediate dose (2.625 μg kg-1 h-1) of SST-14, whether dissolved in albumin or saline alone, was as effective as the standard therapeutic SST-14 dose. We conclude that at these high doses the absorption of a small quantity of SST-14 to glass and plastic surfaces of the infusion sets has no influence on the therapeutic effect.

Journal Section:
Original Paper
Keywords:
Somatostatin, Albumin, Pentagastrin, Gastric acid secretion
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© 1986 S. Karger AG, Basel
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1986
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