Data of 97 patients with acute hepatitis including 37 patients with endogenous hepatic coma are analysed as to their value for early diagnosis of severe hepatitis with impending hepatic coma. In contrast to serum values of transaminases, bilirubin, lactic acid, ammonia and albumin, the Quick value and a II, V, VH-index (sum of clotting factors II, V, and VII) proved a reliable and quantitative parameter of hepatocellular damage when compared with liver biopsy and state of consciousness. Thus II, V, VH-index permits one to judge hepatocellular damage without liver biopsy and to predict impending endogenous hepatic coma. Furthermore signs of secondary aldosteronism were present in 74% of comatose patients and hypoglycemia was observed in 3 patients with endogenous hepatic coma.

Journal Section:
Paper
Keywords:
Blood coagulation tests, Hepatic coma, Hepatitis, infectious, Liver diseases, Liver function tests
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© 1970 S. Karger AG, Basel
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1970
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