The synthetic pentapeptide, pentagastrin (ICI 50 123) has been found to be a suitable stimulant for routine examination of gastric acid secretion. The secretion was examined in 23 patients after subcutaneous injection of 6 and 9 μg, respectively, per kg. An increase of the dose to 9 μg/kg did not cause any increase in peak acid output, and a dose of 6 μg/kg has therefore been accepted as sufficient for maximal gastric stimulation. At this dosage level the results are consistent. In duplicate examinations in 23 patients, the responses had a mean deviation of 9.9%. In 15 cases peak acid output was measured after subcutaneous stimulation with histamine acid phosphate (40 μg/kg) and pentagastrin (6 μg/kg), respectively, and no difference between the two series was found. Of a total of 150 patients, 3 stated they had side effects after injection of pentagastrin. In all 3 cases these were slight and of short duration, and they did not affect the course of the study.

Journal Section:
Paper
Keywords:
Gastric acidity determination, Gastric juice, Gastrin, Histamine, Peptic ulcer
This content is only available via PDF.
© 1970 S. Karger AG, Basel
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
1970
You do not currently have access to this content.