The author has studied enterokinase in 30 normal patients, 68 patients with acute and chronic bacterial, protozoan, and undetermined forms of colitis, and 63 patients with cancer of the rectum, sigmoid, or descending colon. In non-cancer patients, faecal enterokinase activity was significantly increased, but in a vast majority of cancer patients it was found to be normal. Enterokinase studies may be useful for the differential diagnosis of these diseases. Individuals with a persistently high faecal enterokinase activity following bacterial diarrhoea, cannot be regarded as completely normal and therefore need medical supervision to prevent relapse of the disease.

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