The interrelations of meal stimulated gastrin release, antral gastrin concentration (AGC) and acid secretion rate were examined in a heterogenous group of 72 patients. Gastrin release calculated as the integrated gastrin output was directly related to AGC, r = 0.50 (p < 0.001) and inversely related to maximum acid output (MAO), r = -0.31 (p < 0.01). The relation between integrated gastrin output and AGC was significant in 21 patients with low acid secretion rates (MAO: < 10 mEq/h), r = 0.66 (p < 0.01) and in 27 patients with normal acid secretion rates (MAO: 10–25 mEq/h), r = 0.56 (p < 0.05), but not in 24 patients with high acid secretion rates (MAO: > 25 mEq/h), r = 0.35 (p > 0.05). A weak inverse relation between AGC and MAO may exist in patients with low acid secretion rates, r = -0.40 (p < 0.10). Considered together using multiple regression procedures AGC and MAO explained less than one-half of the variability in meal stimulated gastrin release.

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