24-hour basal gastric acid collections were obtained from 14 healthy, young adult male volunteers. The hourly secretary pattern, which described a circadian rhythm, was compared to serial plasma gastrin levels in the subjects who underwent 24-hour gastric intubation and aspiration, subjects who ate and exercised freely and subjects who fasted but were unintubated. A circadian rhythm of plasma gastrin levels was observed only in subjects who ate and exercised freely. The results confirm a previous report which concluded that the circadian pattern of gastric acid secretion is unrelated to plasma gastrin levels and supports the belief that the circadian rhythm of plasma gastrin levels is a result of the effects of feeding on antral gastrin release.

Journal Section:
Original Paper
Keywords:
Circadian rhythm, Fasting, Gastric acidity determination, Gastrin, Radioimmunoassay
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© 1974 S. Karger AG, Basel
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1974
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