... of vascular disease) of plasma tHcy in 326 patients with AD, and also in 281 patients with mild cognitive impairment (MCI), since about half of these patients develop AD during the first 5 years. Results: Elevated plasma tHcy in patients with AD could mainly be attributed to cobalamin/folate deficiency...

... cognitive impairments, showed an increased mortality. These estimates can be used for prognosis and planning for patients, carers, service providers and policy makers. The patients were divided into different groups according to the presence of a diagnosis and/or symptoms indicating vascular disease...

...Arto Nordlund; Mattias Göthlin; Anders Wallin Background/Aims: To study how vascular disease and Alzheimer-typical biomarkers relate to cognitive performance in mild cognitive impairment (MCI). Methods: Three groups diagnosed with MCI, one with vascular disease (MCI-vas, n = 61), one with Alzheimer...

...S.M. Heringa; E. van den Berg; J.M. Dekker; G. Nijpels; R.P.C. Kessels; L.J. Kappelle; C.D.A. Stehouwer; G.J. Biessels Background/Aims: Markers of vascular disease elsewhere in the body may reflect vascular abnormalities in the brain relevant to age-related cognitive decline and dementia. We...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentrations than patients without vascular disease. Increasing evidence...

..., lower renal function and lower serum folate than patients who were still alive. Only age, plasma tHcy and the presence of vascular disease significantly influenced mortality. Conclusion: The association between plasma tHcy level and mortality risk was probably explained in part by the two plasma tHcy...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: Total plasma homocysteine (tHcy) concentration is elevated in patients with psychogeriatric disease. There are many different determinants of plasma tHcy concentration, including the presence of vascular disease. Method: We investigated...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: There is increasing evidence that vascular disease contributes to cognitive impairment and dementia. Clarification of the role of vascular risk factors in dementia is important because most are modifiable, in contrast to other risk factors...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: There is increasing evidence that vascular disease contributes to cognitive impairment and dementia. Clarification of the role of vascular risk factors in dementia is important because most are modifiable, in contrast to other risk factors...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: Plasma total homocysteine (tHcy) is often elevated in patients with mental illness. Since patients with mental illness and vascular disease exhibit a higher plasma tHcy concentration than patients without vascular disease, it is possible...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: There is an association between elevated plasma total homocysteine (tHcy) and vascular disease in elderly patients suffering from organic and non-organic mental disease. The main objective of the present study was to investigate...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: Cobalamin/folate deficiency and vascular disease are prevalent in elderly subjects and may lead to mental symptoms, but may even more often influence the severity of other organic and non-organic mental diseases. In the present study, we...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: There is a high frequency (40–50%) of elevated plasma total homocysteine (tHcy) concentrations in elderly patients with mental disorders, and patients with a history of vascular disease exhibit significantly higher plasma tHcy concentration...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: There is a high frequency of elevated plasma total homocysteine (tHcy) concentrations in elderly patients with mental disorders. Psychogeriatric patients with a history of vascular disease exhibit a significantly higher plasma tHcy...