... with Lewy bodies Alzheimer’s disease dementia Parkinsonism Predementia Carer report Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia and accounts for 15–20% of cases [ 1,2 ]. DLB has a more malignant course in terms of the rate of cognitive decline...

... Hospital memory clinic. Methods: We assessed the number of falls each patient had had in the previous 4 months. The data for DLB patients without motor parkinsonism were analyzed both as part of the whole DLB group and separately to determine the effect of parkinsonism alone on falls. Results: Of 78...

...Katsuji Kobayashi; Masahiro Hayashi; Tomokazu Kidani; Hiroshi Ujike; Masaaki Iijima; Takeshi Ishihara; Hiroyuki Nakano; Kaoru Sugimori; Masao Shimazaki; Shigetoshi Kuroda; Yoshifumi Koshino We report the second phenotype of frontotemporal dementia and parkinsonism linked to chromosome 17 with S305N...

... in attention and alertness, recurrent visual hallucinations and spontaneous motor features of parkinsonism. At least two of these features must be present for the diagnosis of probable DLB. Assessments of the validity of the consensus criteria against autopsy generally indicate high specificity but varying...

... response to tacrine in DLB. Acceleration of parkinsonism occurred in all DLB subjects. Conclusion: Results from a primary analysis of the therapeutic effect of 80 mg/day tacrine in DLB and AD were negative. However, post hoc analysis showed that mild to moderate DLB responds favorably to AChEI relative...

...C. Ballard; J. O’Brien; A. Swann; D. Neill; P. Lantos; C. Holmes; D. Burn; P. Ince; R. Perry; I. McKeith The progression of parkinsonism over 1 year was evaluated in a prospective cohort of patients (n = 338), suffering from dementia with Lewy bodies (DLB), Alzheimer’s disease (AD) or vascular...

... between the two diseases. Eight of the 15 DLB patients (53%) had spontaneous parkinsonism, which was observed in 6 of the 232 AD patients (2.6%). Visual hallucinations were reported by 11 of the 15 DLB patients (73%) and 8 of the 232 AD patients (3.4%). Cognitive fluctuation was positive in 13 of the 15...

...Cristina Geroldi; Giovanni B. Frisoni; A. Bianchetti; Bianchetti Trabucchi; Marco Trabucchi The treatment of Lewy body dementia (LBD) is particularly difficult for the co-occurrence of psychiatric and parkinsonian symptoms: antipsychotic drugs can worsen parkinsonism, and antiparkinsonian drugs can...