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Keywords: N-acetylaspartate
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Journal Articles

Reduced N-Acetylaspartate to Creatine Ratio in the Posterior Cingulate Correlates with Cognition in Alzheimer's Disease following Four Months of Rivastigmine Treatment

Subject Area:
Geriatrics and Gerontology , Neurology and Neuroscience , Psychiatry and Psychology
Jacob Penner, Jennie L. Wells, Michael J. Borrie, Sarah M. Woolmore-Goodwin, Robert Bartha
Journal: Dementia and Geriatric Cognitive Disorders
Dement Geriatr Cogn Disord (2015) 39 (1-2): 68–80.
https://doi.org/10.1159/000367685
Published Online: 24 October 2014
... the metabolite ratios. Results: On average, the N-acetylaspartate/creatine (NAA/Cr) ratio decreased by 12.7% following 4 months of rivastigmine treatment, but changes in the NAA/Cr ratio correlated positively with changes in Mini-Mental State Examination scores. Conclusion: This positive correlation between...
View article titled, Reduced <span class="search-highlight">N</span>-<span class="search-highlight">Acetylaspartate</span> to Creatine Ratio in the Posterior Cingulate Correlates with Cognition in Alzheimer&#x27;s Disease following Four Months of Rivastigmine Treatment
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Journal Articles

Absolute Quantification in Proton Magnetic Resonance Spectroscopy Is Useful to Differentiate Amnesic Mild Cognitive Impairment from Alzheimer’s Disease and Healthy Aging

Subject Area:
Geriatrics and Gerontology , Neurology and Neuroscience , Psychiatry and Psychology
Toshiyuki Watanabe, Akihiko Shiino, Ichiro Akiguchi
Journal: Dementia and Geriatric Cognitive Disorders
Dement Geriatr Cogn Disord (2010) 30 (1): 71–77.
https://doi.org/10.1159/000318750
Published Online: 17 June 2010
... with single-voxel point-resolved spectroscopy at a short echo time (TE) were acquired from 8 volumes of interest in the brain. Results: The bilateral hippocampal N-acetylaspartate (NAA) concentrations from aMCI patients showed intermediate values, which were lower than those from HC subjects but higher than...
View article titled, Absolute Quantification in Proton Magnetic Resonance Spectroscopy Is Useful to Differentiate Amnesic Mild Cognitive Impairment from Alzheimer’s Disease and Healthy Aging
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Journal Articles

Absolute Quantification in Proton Magnetic Resonance Spectroscopy Is Superior to Relative Ratio to Discriminate Alzheimer’s Disease from Binswanger’s Disease

Subject Area:
Geriatrics and Gerontology , Neurology and Neuroscience , Psychiatry and Psychology
Toshiyuki Watanabe, Akihiko Shiino, Ichiro Akiguchi
Journal: Dementia and Geriatric Cognitive Disorders
Dement Geriatr Cogn Disord (2008) 26 (1): 89–100.
https://doi.org/10.1159/000144044
Published Online: 11 July 2008
... acquired from 8 volumes of interest. Results: At 80% specificity, the absolute N-acetylaspartate concentration in the hippocampus was the most sensitive measure to discriminate AD from HC, and the absolute N-acetylaspartate concentration in the anterior periventricular and deep white matter...
View article titled, Absolute Quantification in Proton Magnetic Resonance Spectroscopy Is Superior to Relative Ratio to Discriminate Alzheimer’s Disease from Binswanger’s Disease
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Journal Articles

A Comparative Study of the Different N-Acetylaspartate Measures of the Medial Temporal Lobe in Alzheimer’s Disease

Subject Area:
Geriatrics and Gerontology , Neurology and Neuroscience , Psychiatry and Psychology
Frank Jessen, Frank Traeber, Nikolaus Freymann, Wolfgang Maier, Hans-H. Schild, Reinhard Heun, Wolfgang Block
Journal: Dementia and Geriatric Cognitive Disorders
Dement Geriatr Cogn Disord (2005) 20 (2-3): 178–183.
https://doi.org/10.1159/000087095
Published Online: 19 August 2005
...Frank Jessen; Frank Traeber; Nikolaus Freymann; Wolfgang Maier; Hans-H. Schild; Reinhard Heun; Wolfgang Block Objective: To investigate group differences and correlations and to determine the sensitivity and specificity of different measures of the neuronal marker N-acetylaspartate (NAA...
View article titled, A Comparative Study of the Different <span class="search-highlight">N</span>-<span class="search-highlight">Acetylaspartate</span> Measures of the Medial Temporal Lobe in Alzheimer’s Disease
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