... and raised perioperative cortisol, cytokine, cobalamin and homocysteine levels. Methods: The study recruited 113 consecutive adult patients scheduled for cardiac surgery with cardiopulmonary bypass. The patients were examined preoperatively with the Montreal Cognitive Assessment and Trail Making Test...

...Sigbjørn Rogne; Torgil Vangberg; Petter Eldevik; Gry Wikran; Ellisiv B. Mathiesen; Henrik Schirmer Background/Aims: Late-onset Alzheimer's disease (LOAD) comprises sporadic LOAD and familial LOAD. We wanted to determine whether total plasma homocysteine (Hcy), cardiovascular risk factors...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: A moderate elevation of plasma total homocysteine (tHcy) is considered a potential risk factor for Alzheimer’s disease (AD). Methods: We have investigated the main determinants (age, renal impairment, cobalamin/folate status and the presence...

... plans and assist in medical decisions. Methods: We have investigated the survival time in 2,112 patients with dementia and other forms of psychogeriatric diseases, enrolled during 1990 to 2005 and followed up until 2009, and the influence of diagnoses, plasma homocysteine level, presence of vascular...

...Sunil K. Narayan; Michael J. Firbank; Brian K. Saxby; Gerard Stansby; Monica Hansrani; John T. O’Brien; Gary A. Ford We determined using serial MR imaging whether raised plasma homocysteine levels are associated with increased brain atrophy, white matter lesion (WML) progression or incidence...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentrations than patients without vascular disease. Increasing evidence...

...Johannes Levin; Kai Bötzel; Armin Giese; Michael Vogeser; Stefan Lorenzl Background/Aims: Increasing evidence suggests that elevated levels of homocysteine (Hcy) and methylmalonate (MMA) may be involved in the pathogenesis of neurodegenerative diseases. Methods: The urine levels of MMA and serum...

...Sylvia Annerbo; Miia Kivipelto; Johan Lökk Background/Aim: The combination of elevated total homocysteine (tHcy) levels and low levels of thyroid-stimulating hormone (TSH) are linked to Alzheimer’s disease (AD) in some studies, although the evidence is mixed. Our objective was to prospectively...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background/Method: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness. Plasma tHcy is known to be associated with cardiovascular disease, renal impairment and negative lifestyle factors, and has been shown...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: Total plasma homocysteine (tHcy) concentration is elevated in patients with psychogeriatric disease. There are many different determinants of plasma tHcy concentration, including the presence of vascular disease. Method: We investigated...

...Christiane Reitz; Ming-Xin Tang; Joshua Miller; Ralph Green; José A. Luchsinger Background and Objective: There are conflicting data relating homocysteine levels to the risk of Alzheimer’s disease (AD). We sought to explore whether fasting plasma homocysteine is associated with the risk of mild...

...Isabel Sala; María Belén Sánchez-Saudinós; Laura Molina-Porcel; Estela Lázaro; Ignasi Gich; Jordi Clarimón; Francisco Blanco-Vaca; Rafael Blesa; Teresa Gómez-Isla; Alberto Lleó Background/Aims: Elevated total plasma homocysteine (tHcy) is a risk factor for cardiovascular and cerebrovascular disease...

...Ling Li; Dongfeng Cao; Renee Desmond; Atiq Rahman; James J. Lah; Allan I. Levey; Edward Zamrini Background: Conflicting results have been reported on the association of plasma total homocysteine (tHcy) and cholesterol levels in Alzheimer disease (AD). The objective of this study was to determine...

... Homocysteine Psychogeriatric patients Vascular disease Original Research Article Dement Geriatr Cogn Disord 2008;26:251 256 DOI: 10.1159/000160957 Accepted: July 4, 2008 Published online: October 8, 2008 C-Reactive Protein: Vascular Risk Marker in Elderly Patients with Mental Illness Karin Nilssona Lars...

...) the mean R CSF/S ± SD was 2.46 ± 0.62 versus 2.09 ± 0.67 (p = 0.008) in the dementia subgroup with a vascular component (VaD + mixed). The ND subgroup had higher CSF folate (p = 0.001) and lower serum homocysteine values (p = 0.001) than the VaD + mixed subgroup. The folate gradient R CSF/S was negatively...

...Brendan Silbert; Lisbeth Evered; David A. Scott; Craig McCutcheon; Konrad Jamrozik Background: Raised concentrations of plasma homocysteine and C-reactive protein (CRP) are associated with vascular disease and have also been implicated as independent risk factors for cognitive impairment...

... such as age and genetics. Methods: In 451 patients with mental illness we have investigated three biochemical markers related to vascular disease, total plasma homocysteine (tHcy), cystatin C, and N-terminal-pro brain natriuretic peptide (NT-proBNP), and their association with vascular disease, diagnoses...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: Plasma total homocysteine (tHcy) is often elevated in patients with mental illness. Since patients with mental illness and vascular disease exhibit a higher plasma tHcy concentration than patients without vascular disease, it is possible...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: There is an association between elevated plasma total homocysteine (tHcy) and vascular disease in elderly patients suffering from organic and non-organic mental disease. The main objective of the present study was to investigate...

... studies in dementia was lack of concurrent homocysteine measurement especially as it may provide a better indicator of tissue activities of these vitamins. This study was designed to clarify whether a relationship exists between plasma homocysteine concentration and BPSD. Methods: Plasma homocysteine...