...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: A moderate elevation of plasma total homocysteine (tHcy) is considered a potential risk factor for Alzheimer’s disease (AD). Methods: We have investigated the main determinants (age, renal impairment, cobalamin/folate status and the presence...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Alzheimer’s disease Cobalamin Creatinine Dementia Depression Folate Homocysteine Mild cognitive impairment Psychogeriatric patients Vascular dementia Vascular disease Many studies...

... of silent brain infarcts (SBIs) in older hypertensive subjects. Brain atrophy rates (0.58 ± 0.48% per year, mean ± SD) were significantly correlated with homocysteine (β = 0.46, p = 0.001 homocysteine; β = 0.44, p = 0.007 homocysteine/folate/B12 models) but not with folate or B12 levels. Progression of WML...

... Gustafson a Björn Hultberg b a Departments of Psychogeriatrics, Clinical Science and b Laboratory Medicine, Division of Clinical Chemistry, Lund University Hospital, Lund, Sweden Key Words Cobalamin Cognition Creatinine Cystatin C Folate Homocysteine Psychogeriatric patients Vascular disease...

..., lower renal function and lower serum folate than patients who were still alive. Only age, plasma tHcy and the presence of vascular disease significantly influenced mortality. Conclusion: The association between plasma tHcy level and mortality risk was probably explained in part by the two plasma tHcy...

... without vascular disease even after exclusion of patients with folate/cobalamin deficiency. Patients with elevated serum creatinine with or without vascular disease exhibited significantly increased plasma tHcy compared to the respective groups of patients without elevated serum creatinine. Patients...

... with cognitive impairment. Methods: Plasma tHcy, folate, vitamin B12 and creatinine levels were assessed in individuals evaluated at the Memory Disorder Unit. Diagnoses included subjective memory complaints (SMC, n = 27), mild cognitive impairment (MCI, n = 142), AD (n = 139) and vascular dementia (VD, n = 17...

...Nils-Olof Hagnelius; Lars-Olof Wahlund; Torbjörn K. Nilsson Background: Folate depletion has been implicated as a risk factor for neurodegenerative disorders. We hypothesized that transport of folate to the cerebrospinal fluid (CSF) compartment could be involved in the pathophysiology...

...Åke Wahlin; Kjell Fahlander; Tarja-Brita Robins Wahlin; David Bunce; Lars Bäckman Background/Aims: The impact of vitamin B status on cognitive functioning in Alzheimer’s disease (AD) is disputed. Using a population-based sample, we examined the associations of vitamin B 12 and folate with cognitive...

... that elevated plasma tHcy in mental illness is mainly due to concomitant vascular disease. Methods: We have investigated plasma tHcy, cobalamin/folate status, renal function and the presence of vascular disease in patients with vascular dementia (VaD, n = 501), Alzheimer’s disease (AD, n = 300), depression (n...

... with subjective memory complaints (SMC, n = 22). The group of CMC patients with vascular disease had higher age, higher plasma tHcy, lower serum folate and lower renal function than patients without vascular disease. Conclusion: The finding of two subgroups of patients with CMC supports the notion that mild...

...N. Tabet; H. Rafi; G. Weaving; B. Lyons; S.A. Iversen Background/Aims: Vitamin B12 and folate deficiencies have been associated with cognitive impairment and various psychiatric symptoms but not specifically with behavioural and psychological symptoms of dementia (BPSD). A limitation of previous...

...Karin Nilsson; Lars Gustafson; Björn Hultberg Background: Cobalamin/folate deficiency and vascular disease are prevalent in elderly subjects and may lead to mental symptoms, but may even more often influence the severity of other organic and non-organic mental diseases. In the present study, we...

... and its most important determinants (folate and cobalamin status and renal function), and the natriuretic peptide N-terminal-pro brain natriuretic peptide (NT-proBNP). The patients were classified into several groups of vascular disease according to the findings of brain imaging and presence of a history...

... and its most important determinants (serum folate and serum cobalamin, serum cystatin C and serum creatinine). The patients were divided into two groups according to the presence of vascular disease. Eighty-seven patients had concomitant vascular disease. We also analysed the natriuretic peptide N...

...K. Nägga; R. Rajani; E. Mårdh; K. Borch; S. Mårdh; J. Marcusson The prevalence of dementia disorders, cobalamin and/or folate deficiency as well as gastritis increases with age. To investigate whether there is an association between these conditions, plasma homocysteine (Hcy), serum methylmalonic...

...Martin Lehmann; Björn Regland; Kaj Blennow; C.G. Gottfries Thirty patients had mild cognitive impairment and increased homocysteine levels in serum. On average, they were supplemented orally with a high dose of a vitamin B 12 -B 6 -folate combination for 270 days. All patients had normal serum B 12...

...Karin Nilsson; Björn Hultberg; Lars Gustafson Background/Objectives: In previous studies we observed a high incidence of elevated plasma homocysteine (tHcy) concentrations in psychogeriatric patients. Plasma tHcy is increased in folate deficiency. Folates are sensitive to oxidative stress...

..., instructions or products referred to in the content or advertisements. Alzheimer’s disease Cardiovascular disease Cobalamin Creatinine Folate Homocysteine Vascular dementia Original Research Article Dement Geriatr Cogn Disord 2002;14:7 12 Received: August 2, 2001 Accepted after revision...

...Colleen J. Maxwell; David B. Hogan; Erika M. Ebly Recent epidemiologic studies have shown an association between low serum folate levels and risk of vascular disease, including stroke and various types of vascular cognitive impairment. We examined data from the Canadian Study of Health and Aging...