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1-5 of 5
Keywords: Down syndrome
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Journal Articles
Qi Zhao, Joseph H. Lee, Deborah Pang, Alexis Temkin, Naeun Park, Sarah C. Janicki, Warren B. Zigman, Wayne Silverman, Benjamin Tycko, Nicole Schupf
Dement Geriatr Cogn Disord (2012) 32 (4): 241–249.
Published Online: 08 December 2011
... of polymorphisms in the gene for the estrogen receptor-beta (ESR2) to the risk of AD in women with Down syndrome. Methods: Two hundred and forty-nine women with Down syndrome, 31–70 years of age and nondemented at baseline, were followed at 14- to 18-month intervals for 4 years. Women were genotyped for 13 single...
Journal Articles
Dement Geriatr Cogn Disord (2008) 26 (3): 199–202.
Published Online: 03 September 2008
...Emma L. Jones; Marisa Margallo-Lana; Vee P. Prasher; Clive G. Ballard Background/Aims: Most people with Down syndrome (DS) develop Alzheimer’s disease (AD). The extended tau haplotype has been linked to AD. In this study, we examined the haplotype’s effect on the age of onset of AD in DS. Methods...
Journal Articles
Nicole Schupf, Joseph H. Lee, Michelle Wei, Deborah Pang, Constance Chace, Rong Cheng, Warren B. Zigman, Benjamin Tycko, Wayne Silverman
Dement Geriatr Cogn Disord (2008) 25 (5): 476–482.
Published Online: 14 April 2008
...) in the first intron of estrogen receptor 1 (ESR1) , the gene for ER-α, have been reported to influence estrogen receptor expression and may influence the risk of AD. Methods: We examined the relation of polymorphisms in ESR1 to the risk of AD in women with Down syndrome. The subjects (181 women with DS, 41–78...
Journal Articles
Hillevi Englund, Göran Annerén, Jan Gustafsson, Ulrika Wester, Jens Wiltfang, Lars Lannfelt, Kaj Blennow, Kina Höglund
Dement Geriatr Cogn Disord (2007) 24 (5): 369–374.
Published Online: 03 October 2007
...Hillevi Englund; Göran Annerén; Jan Gustafsson; Ulrika Wester; Jens Wiltfang; Lars Lannfelt; Kaj Blennow; Kina Höglund Background: Individuals with Down syndrome (DS) invariably develop Alzheimer’s disease (AD) during their life span. It is therefore of importance to study young DS patients when...
Journal Articles
Dement Geriatr Cogn Disord (2001) 12 (3): 219–225.
Published Online: 09 March 2001
.... We therefore investigated synaptosomal proteins in brain specimens from patients with Down syndrome (DS) and Alzheimer’s disease (AD) to challenge the DS synaptic pathology as well as the relevance of DS to AD in synaptic pathology. For the aim of this study, we employed two-dimensional...
