...Dimitrios Adamis; Piet Eikelenboom Background: The relationship between delirium and low levels of insulin-like growth factor 1 (IGF-1) is contradictory and uncertain. We hypothesised that low levels of IGF-1 are a predisposing factor for delirium in medical and abdominal surgical cohorts...

... for identification of delirium prevents direct comparison of studies and the ability to combine results. In a recent systematic review we performed, we recommended four commonly used and well-validated instruments and subsequently harmonized them using advanced psychometric methods to develop an item bank...

...Helen Senderovich; Sandra Gardner; Anna Berall; Michael Ganion; Dennis Zhang; Danusha Vinoraj; Sarah Waicus Introduction: Patients often experience delirium at the end of life. Benzodiazepine use may be associated with an increased risk of developing delirium. Alternate medications used...

...Roope Jaatinen; Tiina Luukkaala; Markus T. Hongisto; Heli Helminen; Maria S. Nuotio Background: Older hip fracture patients are at high risk of delirium during acute hospital care. Pre-fracture dementia is known to increase the risk of in-hospital delirium. Data on the development of new cognitive...

...Paul Thisayakorn; Sookjaroen Tangwongchai; Saran Tantavisut; Yanin Thipakorn; Siree Sukhanonsawat; Tanya Wongwarawipat; Sunee Sirivichayakul; Michael Maes Background: Postoperative delirium in elderly people with hip fracture is associated with various adverse clinical outcomes. Nevertheless...

... by DLB. While there is now largely a consensus which tools are useful in diagnosing DLB, their validity in assessing deteriorating cognition is less clear. Thirdly, the presence of fluctuating cognition, the propensity to develop delirium episodes, as well as difficulties in distinguishing the two...

...Joost Witlox; Dimitrios Adamis; Leo Koenderman; Kees Kalisvaart; Jos F.M. de Jonghe; Alexander P.J. Houdijk; Alasdair M.J. Maclullich; Piet Eikelenboom; Willem A. van Gool Background: Ageing, depression, and neurodegenerative disease are common risk factors for delirium in the elderly. These risk...

...: Delirium is a common and preventable geriatric syndrome. Moving beyond the binary classification of delirium present/absent, delirium severity represents a potentially important outcome for evaluating preventive and treatment interventions and tracking the course of patients. Although several delirium...

... settings [ 5, 9-12 ], emergency departments [ 13 ], and hospitalized older adults with delirium [ 14 ] have found sensitivities ranging from 68 to 100% and specificities ranging from 17 to 90% with AUCs of 0.62–0.97. We used a prespecified cutoff of ≥2 to indicate pre-existing dementia, consistent...

...Mohamed Eshmawey; Sönke Arlt; Christine Ledschbor-Frahnert; Ulf Guenther; Julius Popp Background: Delirium is common in old patients who undergo cardiac surgery, and it is associated with adverse outcomes. The genesis of delirium is thought to be multi-factorial, but it is still not well understood...

...Nathalie Bodd Halaas; Kaj Blennow; Ane-Victoria Idland; Torgeir Bruun Wyller; Johan Ræder; Frede Frihagen; Anne Cathrine Staff; Henrik Zetterberg; Leiv Otto Watne Background: Delirium is associated with new-onset dementia, suggesting that delirium pathophysiology involves neuronal injury...

... Study Group on Delirium Background: Delirium is a common geriatric syndrome. Few studies have been conducted in nursing home (NH) residents. The aim of this project was to perform a point prevalence study of delirium in Italian NHs. Methods: Data collected in 71 NHs are presented. Inclusion criteria...

...Neus Gual; Alessandro Morandi; Laura Monica Pérez; Laura Brítez; Pamela Burbano; Flor Man; Marco Inzitari Background: Delirium research is poorly studied in postacute care, a growing setting due to aging populations, as well as in dementia, a critical risk factor for delirium and particularly...

... for prevalent delirium in older hospitalised adults in Sub-Saharan Africa (SSA) remain poorly characterised. Methods: A total of 510 consecutive admissions of adults aged ≥60 years to acute medical wards of Kilimanjaro Christian Medical Centre in northern Tanzania were recruited. Patients were assessed within...

...Thomas A. Jackson; Hannah C. Moorey; Bart Sheehan; Alasdair M.J. Maclullich; John R. Gladman; Janet M. Lord Aims: Cholinergic deficiency is commonly implicated in the pathophysiology of delirium. We aimed to investigate the relationship between directly measured serum acetylcholinesterase (AChE...

...Karen Roksund Hov; Jens Petter Berg; Frede Frihagen; Johan Ræder; Roanna Hall; Torgeir Bruun Wyller; Leiv Otto Watne Background/Aims: Delirium is a common and serious complication in hospitalised patients and its pathophysiology is incompletely understood. We aimed to examine whether blood...

...Angelique Egberts; Eline H.A. Wijnbeld; Durk Fekkes; Milly A. van der Ploeg; Gijsbertus Ziere; Herbert Hooijkaas; Tischa J.M. van der Cammen; Francesco U.S. Mattace-Raso Background/Aims: The diagnosis of delirium is not supported by specific biomarkers. In a previous study, high neopterin levels...

...Stacie Deiner; Hung-Mo Lin; Daniella Bodansky; Jeffrey Silverstein; Mary Sano Background: Postoperative delirium (PD) is a prevalent complication of elderly surgical patients, which predisposes to worsened cognitive recovery and dementia. Risk of PD has been associated with increasing magnitude...

...N. Martínez Velilla; Cristina Alonso Bouzon; Koldo Cambra Contin; Berta Ibáñez Beroiz; Álvaro Casas Herrero; Javier Alonso Renedo Background: Subsyndromal delirium has an increasing relevance in the medical literature. There are only three studies in hospitalized elderly patients. Our goal...

...G.I. Ringdal; K. Ringdal; V. Juliebø; T.B. Wyller; M.J. Hjermstad; J.H. Loge Background: The main aim of this paper was to examine the usefulness of the Mini-Mental State Examination (MMSE) for screening delirium in elderly patients with hip fracture. Methods: The sample included 364 elderly...