...Shazma Khan; Sara Khan Introduction: Sporadic Creutzfeldt-Jakob disease (sCJD) is a transmissible disorder of the central nervous system caused by the transformation of normal prion protein into an abnormal misfolded form. The process begins spontaneously and runs a vicious cycle to cause...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Prion disease Creutzfeldt-Jakob disease Remote assessment Teleneurology Telemedicine Human prion diseases are rapidly progressive neurodegenerative conditions...

... ubiquitin-proteasome system and are involved in the pathogenesis of several human diseases, including polyglutamine diseases. HECTD2 , an E3 ubiquitin ligase, has been linked to the incubation time of prion disease in mice, and its polymorphisms have been associated with sporadic Creutzfeldt-Jakob disease...

...Brian S. Appleby; Kristin K. Appleby; Ryan C.W. Hall; Mitchell T. Wallin Background: Fatal familial insomnia (FFI) and genetic Creutzfeldt-Jakob disease (CJD D178N, 129V ) are two phenotypes that share a common point mutation at codon 178 of the prion protein gene (PRNP) , but differ...

... Geriatr Cogn Disord 2009;28:550 557 DOI: 10.1159/000254842 Accepted: October 7, 2009 Published online: December 30, 2009 Familial Creutzfeldt-Jakob Disease with a V180I Mutation: Comparative Analysis with Pathological Findings and Diffusion-Weighted Images Kazuo Mutsukuraa Katsuya Satoha Susumu Shirabec...

... in vitro by cleaving the amyloid precursor protein into amyloid beta protein. In recent studies, cathepsin D was co-localized with PrP Sc , the disease-associated form of the prion disease, and abnormal expression of cathepsin D correlated with tissue damage in brains of sporadic Creutzfeldt-Jakob disease...

... observed on electroencephalographs and the detection of 14-3-3 protein in cerebrospinal fluid (CSF) as diagnostic criteria for Creutzfeldt-Jakob disease (CJD). Diffusion-weighted magnetic resonance imaging (DWI) and the detection of total tau (t-tau) protein in CSF may be more sensitive diagnostic criteria...

...Katsuya Satoh; Susumu Shirabe; Hiroto Eguchi; Akira Tsujino; Masakatsu Motomura; Akira Satoh; Mitsuhiro Tsujihata; Katsumi Eguchi Background: There are currently no markers for evaluating chronological changes in Creutzfeldt-Jakob disease (CJD). We examined if chronological changes in biochemical...

...Lukas Cepek; Peter Brechlin; Petra Steinacker; Brit Mollenhauer; Enrico Klingebiel; Mirko Bibl; Hans A. Kretzschmar; Jens Wiltfang; Markus Otto So far, only the detection of 14-3-3 proteins in cerebrospinal fluid (CSF) has been accepted as diagnostic criterion for Creutzfeldt-Jakob disease (CJD...

... of Creutzfeldt-Jakob disease (CJD). So far there has been only limited information available about the dynamics of these parameters in the cerebrospinal fluid (CSF). However, there is a special interest in finding biochemical markers to monitor disease progression for differential diagnosis and treatment...

...H. Schmidt; M. Otto; P. Niedmann; L. Cepek; A. Schröter; H.A. Kretzschmar; S. Poser The diagnosis of Creutzfeldt-Jakob disease (CJD) is still made by exclusion of other dementias. We now evaluated lactate dehydrogenase (LDH) in the cerebrospinal fluid (CSF) as a possible additional diagnostic tool...

... Creutzfeldt-Jakob disease (CJD) and to one with iatrogenic CJD. Quinacrine at 300 mg/day was given enterally for 3 months. Within 2 weeks of administration, the arousal level of the patient with akinetic mutism improved. The other 3 patients, insensible before treatment, had integrative responses such as eye...

..., instructions or products referred to in the content or advertisements. Creutzfeldt-Jakob disease Cerebrospinal fluid 14-3-3 protein Neuron-specific enolase S-100 protein Original Research Article Dement Geriatr Cogn Disord 1999;10:40 46 Accepted: May 5, 1998 14-3-3 Protein, Neuron-Specific Enolase...