... increased cholesterol level has been acknowledged as a risk factor for dementia, evidence synthesis based on published data has yielded mixed results. This is especially relevant in older adults where individual studies report non-linear relationships between cholesterol and cognition and, in some cases...

... home placement and a primary cause of stress for caregivers. Elevated cholesterol has been linked to psychiatric disorders and has been shown to be a risk factor for AD and to impact disease progression. The present study investigated the relationship between cholesterol and NPS in AD. Methods: Data...

...Mitzi M. Gonzales; Takashi Tarumi; Danielle E. Eagan; Hirofumi Tanaka; Fedora O. Biney; Andreana P. Haley Aims: Given that high cholesterol levels at midlife are a risk factor for future cognitive decline, the goal of the current study was to determine if cholesterol-related alterations...

...Miika Vuorinen; Alina Solomon; Suvi Rovio; Lasse Nieminen; Ingemar Kåreholt; Jaakko Tuomilehto; Hilkka Soininen; Miia Kivipelto Background/Aims: This study investigated the relation of midlife blood pressure, total cholesterol, body mass index (BMI), their changes over time, apolipoprotein E...

...), and phosphorylation of tau is accelerated by the increase in the level of neuronal cholesterol. Apolipoprotein E (APOE) promotes the neuronal uptake of cholesterol via APOE receptors such as the low-density lipoprotein receptor-related protein 1 (LRP1), and the APOE ε4 allele is associated with an increase in NFT...

...Alina Solomon; Miia Kivipelto; Benjamin Wolozin; Jufen Zhou; Rachel A. Whitmer Aims: To investigate midlife cholesterol in relation to Alzheimer’s disease (AD) and vascular dementia (VaD) in a large multiethnic cohort of women and men. Methods: The Kaiser Permanente Northern California Medical...

.... Results: Residents with any AD pathology, as compared to those without AD pathology, had higher mean serum total cholesterol (TC; 200.4 vs. 185.9 mg/dl; p = 0.02) and higher mean low-density lipoprotein cholesterol (LDL; 124.5 vs. 111.5 mg/dl; p = 0.03). Further, mean TC, LDL and high-density lipoprotein...

...Ling Li; Dongfeng Cao; Renee Desmond; Atiq Rahman; James J. Lah; Allan I. Levey; Edward Zamrini Background: Conflicting results have been reported on the association of plasma total homocysteine (tHcy) and cholesterol levels in Alzheimer disease (AD). The objective of this study was to determine...

... are associated with vascular diseases, but their relation to dementia is unclear. This review examines biological and epidemiological evidence concerning the role of these hematologic factors in dementia, and dementia subtypes. Reviewed factors include homocysteine, cholesterol, fatty acids, antioxidants, and C...

...Taku Ohkubo; Nobuto Shibata; Tohru Ohnuma; Shinji Higashi; Chie Usui; Akira Ueki; Masatsugu Nagao; Heii Arai The identification of the ε4 variant of apolipoprotein E as a genetic risk factor for late-onset Alzheimer’s disease (AD) suggests that cholesterol may play a direct role in the pathogenesis...

..., focused on statin therapy in patients with ischemic heart disease (IHD), are at variance. Nonetheless, data from epidemiological, longitudinal studies in humans as well as studies on transgenic mouse models and cultured neuronal cell lines indicate that cholesterol may contribute to the pathogenesis of AD...

.... Cholesterol and triglyceride levels partially explained effects of Ε2, but did not account for those of Ε4. A reduced association between Ε4 and later AD in populations of African origin is unlikely to be explained by reduced cognitive effects or by differential mortality. However, it may be accounted...

... = 22). In contrast to most other reports of serum lipids in very old patients with AD, total cholesterol (TC) and low density lipoprotein cholesterol levels were each significantly higher for those with AD. The lipid-AD associations were progressively stronger with increasing pathological certainty...

...G.P. Eckert; N.J. Cairns; A. Maras; W.F. Gattaz; W.E. Müller Cholesterol represents an important determinant of the physical state of biological membranes. In Alzheimer’s disease (AD) brains, specific changes in the distribution of cholesterol and its membrane-ordering effects take place...