... ADAM10 plays a central role in AD pathology, attenuating the formation of beta-amyloid peptides and, therefore, their aggregation into senile plaques. This study seeks to investigate ADAM10 as a blood-based biomarker in mild cognitive impairment (MCI) and AD in a diverse group of community-dwelling older...

... of AD in early stages of illness (mild cognitive impairment [MCI], early dementia) becomes increasingly important. Biomarkers for AD in low- and middle-income countries (LMICs) are costly and not widely available; hence, it is important to identify cognitive tests that correlate well with AD biomarker...

..., and identifying reliable biomarkers has been challenging. Methods: This study included 132 participants aged 50 and older from greater San Diego County. The participants were divided into three groups: PLWH with HAND ( n = 29), PLWH without HAND ( n = 73), and seronegatives without cognitive impairment ( n = 30...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 Delirium Insulin-like growth factor 1 Pathophysiology Biomarkers Systematic review Meta-analysis Delirium is a neuropsychiatric...

... Introduction: Several recent research studies show high performance of blood biomarkers to identify Alzheimer’s disease also in the pre-dementia mild cognitive impairment (MCI) stage, but data from the routine clinical care memory clinic setting are needed. Methods: We examined plasma samples of 144 memory...

... in patients with Alzheimer’s disease (AD). However, no studies have examined its relationship with AD-related biomarkers. Methods: One-hundred twenty-one older adults (intact, amnestic mild cognitive impairment, mild AD) completed the QDRS, and three biomarkers (amyloid deposition via positron emission...

... to in the content or advertisements. Alcoholic dementia Biomarkers Cognitive assessment Mild cognitive impairment Long-term and extensive alcohol consumption can lead to reduced cognitive performance [1, 2] and is identified as one of the most important risk factors for dementia [3-5...

..., instructions or products referred to in the content or advertisements. 2020 Alzheimer’s disease Clinical trials Drug development Translational scoring Biomarkers Target product profile Toxicity Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with cognitive, functional...

... differed between FTD patients and controls, across different clinical and genetic subtypes of FTD, and between individuals with a clinical FTD syndrome due to AD versus non-AD (frontotemporal lobar degeneration, FTLD) pathology (based on CSF neurodegenerative biomarkers). Eighteen healthy controls and 64...

... identified several risk factors for dementia and cognitive decline – the prodromal stage of dementia, and nutritional biomarkers, especially serum albumin and hemoglobin levels, are good predictors of cognitive deterioration. In longitudinal studies, Ng et al. [ 1 ] reported that low albumin levels were...

... ELISAs (Innotest; Fujirebio, Gent, Belgium) were used for measurements. Results: According to the current cutoff values of our laboratory, 4 biomarker profiles were noted: abnormal levels of Aβ 42 only (44.7%), full AD profile (39.5%), abnormal levels of τ T only (5.3%), and normal levels of all 3...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Amyloid Alzheimer’s disease Biomarkers Dementia Mild cognitive...

... to similar underlying mechanisms. Methods: We identified 41 EOAD patients (18 amnestic, 14 with LPA, and 9 with PCA) with CSF and brain MRI data. Semiquantitative ratings were used to assess medial temporal lobe atrophy and PCA, which were compared to CSF biomarker indices. Results: Lower CSF tau levels were...

... and the A allele of rs1277306 (Table 7 ). Table 7 Multivariable logistic regression analysis for the rs1713985 and rs1277306 interaction model Alzheimer diseases Biomarkers Cognitive aging Cognitive function Cognitive impairment Mini-Mental State Examination Neurodegeneration The RE1...

...Franc Llorens; André Karch; Ewa Golanska; Matthias Schmitz; Peter Lange; Beata Sikorska; Pawel P. Liberski; Inga Zerr Background: Several biomarkers have been proposed to discriminate sporadic Creutzfeldt-Jakob disease (sCJD) from other dementias and control cases. However, their clinical accuracy...

... for behavioral variant frontotemporal dementia (bvFTD) incorporate MRI and [ 18 F]-FDG-PET. Cerebrospinal fluid (CSF) analysis is merely advised for excluding Alzheimer's disease. Aims: We aimed to assess the impact of biomarkers on diagnostic certainty and contingent changes of bvFTD diagnosis within...

...Nina Rostgaard; Gunhild Waldemar; Jørgen Erik Nielsen; Anja Hviid Simonsen As dementia is a fast-growing health care problem, it is becoming an increasingly urgent need to provide an early diagnosis in order to offer patients the best medical treatment and care. Validated biomarkers which reflect...

... (ALS). The C9ORF72 expansion is associated with TDP-43 and p62 neuropathology, and amyloid plaques and neurofibrillary tangles are not common in patients with the C9ORF72 expansion. Therefore, we hypothesized that cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease [AD; Aβ 1-42 , total tau (T...

... Pittsburgh Compound B retention. In this high-risk group, plasma ApoE levels may represent a peripheral marker of underlying AD neuropathology in nondemented elderly individuals. Alzheimerߣs disease Mild cognitive impairment Magnetic resonance imaging Hippocampus Biomarkers ADNI Apolipoprotein E...

...Angelique Egberts; Eline H.A. Wijnbeld; Durk Fekkes; Milly A. van der Ploeg; Gijsbertus Ziere; Herbert Hooijkaas; Tischa J.M. van der Cammen; Francesco U.S. Mattace-Raso Background/Aims: The diagnosis of delirium is not supported by specific biomarkers. In a previous study, high neopterin levels...