...Karin Persson; Trine H. Edwin; Anne-Brita Knapskog; Gro G. Tangen; Geir Selbæk; Knut Engedal Introduction: One pathological hallmark of Alzheimer’s disease (AD) is atrophy of medial temporal brain regions that can be visualized on magnetic resonance imaging (MRI), but not all patients will have...

... and right precuneus) and one cluster in the white matter (left middle frontal gyrus). In contrast, the grade of white matter hyperintensities did not differ according to the use of VKA. Conclusion: We found focal atrophies in older adults exposed to VKA. These findings provide new insights elucidating...

... ]. FDG PET is a functional marker of cortical glucose metabolism, and MRI gives a structural measure of grey matter density [ 23 ]. Cortical hypometabolism is postulated to precede and possibly lead to cortical atrophy [ 3 ], but the correlation between FDG PET and MRI is not particularly strong...

...-domain amnestic MCI (mdMCI) patients, and controls. Methods: Nineteen patients characterized as aMCI were compared with 24 mdMCI patients and 31 controls by means of an automatic HP segmentation procedure. Results: We found significant atrophy of the PRC and ERC in aMCI relative to controls, whereas...

...Minwei Zhu; Xudong Wang; Wenpeng Gao; Chen Shi; Haitao Ge; Hong Shen; Zhiguo Lin Background: We investigated the rate of corpus callosum (CC) atrophy and its association with cognitive decline in early Alzheimer's disease (AD). Methods: We used publicly available longitudinal MRI data corresponding...

.... During the early stages, clinical distinction between them is often challenging. Our objective is to compare hippocampal atrophy patterns in mild AD and mild DLB. We hypothesized that DLB subjects have milder hippocampal atrophy relative to AD subjects. Methods: We analyzed the T1-weighted magnetic...

... variability of medial temporal lobe atrophy (MTA) in patients with Alzheimer’s disease (AD) recruited in a European observational study of AD. Methods: 117 mild to moderate AD patients from 5 European centers (Amsterdam, The Netherlands; Brescia and Genova, Italy; Mannheim, Germany; Pamplona, Spain) had...

... of apathy in AD have not yet been described. Methods: We analyzed magnetic resonance imaging data of 35 AD patients with and without apathy. Results: There was a significant linear association between apathy severity and cortical gray matter atrophy in the bilateral anterior cingulate [Brodmann area (BA) 24...

...Josephine Barnes; Rachael I. Scahill; Jonathan M. Schott; Chris Frost; Martin N. Rossor; Nick C. Fox Objective: To determine whether Alzheimer’s disease (AD) is associated with preferential atrophy of either the left or right hippocampus. Methods: We examined right-left asymmetry in hippocampal...

... with mixed dementia (AD and vascular dementia, VaD), 71 with VaD, and 12 cases that were not demented. Temporal cortical atrophy and atrophy around the temporal horns were more common in patients with mixed dementia compared to patients with VaD and the non-demented, respectively. Frontal white matter...

... hemispheres. Neurons were also counted in the inferior olivary nucleus. In vermis of the AD cases, the mean PC number was significantly lower (p = 0.019) than in the controls. The neurons in the inferior olive were similarly fewer, though not significantly (p = 0.13). Molecular layer gliosis and atrophy...