... neurodegenerative diseases. We assessed the vascular density of CAA by analyzing the expression of complement (C1q, C3d, C6, C5b-9), macrophage scavenger receptor (MSR), and apolipoprotein E (ApoE). Results: Capillary immunostaining for C1q, C3d, MSR, and ApoE was identified almost exclusively in CAA-type1 brains...

... supplementary Table 2. Apolipoprotein E Serum Biomarker Plasma Case-control study Alzheimer disease Alzheimer disease (AD) is characterized by progressive impairment of memory, cognitive functions, and activities of daily living along with abnormal behavior caused by neuronal degeneration...

...P.S. Jairani; P.M. Aswathy; Srinivas Gopala; Joe Verghese; P.S. Mathuranath Background: This study delineates the role of the interaction of apolipoprotein E (APOE) and MAPT alleles in contributing to disease risks of dementia in a southern Indian population. Methods: A sample of 419 patients...

...Bjørn Heine Strand; Tor Atle Rosness; Knut Engedal; Per Magnus; Astrid Liv Mina Bergem; Henrik Schirmer; Espen Bjertness; Gun Peggy Knudsen; for the GENIDEM group Background/Aims: Our aims were two-fold: firstly, to investigate the association and interaction between apolipoprotein E (ApoE...

...Edmond Teng; Nicole Chow; Kristy S. Hwang; Paul M. Thompson; Karen H. Gylys; Gregory M. Cole; Clifford R. Jack Jr.; Leslie M. Shaw; John Q. Trojanowski; Holly D. Soares; Michael W. Weiner; Liana G. Apostolova; for the Alzheimer''s Disease Neuroimaging Initiative Apolipoprotein E (APOE) genotype...

...Yong Ji; Mengyuan Liu; Ya Ruth Huo; Shuling Liu; Zhihong Shi; Shuai Liu; Thomas Wisniewski; Jinhuan Wang The relationship between the apolipoprotein E (ApoE) ε4 genotype and an increased risk of developing Alzheimer's disease (AD) has been well established in Caucasians but is less established...

... of dementia are found in approximately 30% of PD patients. Both apolipoprotein E (APO E) and ubiquitin carboxyl-terminal esterase L1 (UCHL1) are neuropathogenic proteins for both diseases. The aim of this study was to investigate whether polymorphisms of both genes are associated with AD and PD with dementia...

...Bo Liu; Yuefei Shen; Luan Cen; Yulan Tang Background: Apolipoprotein E (ApoE) gene has been reported to be associated with the development of vascular dementia (VD); however, results from observational studies are conflicting. Methods: We surveyed all case-control studies on ApoE gene and VD...

... impairment (MCIa) to AD. The aim of this study was to examine the role of ER single nucleotide polymorphisms (SNPs) as a risk factor for MCIa, as well as the interaction with apolipoprotein E (APOE) Ε4 in the progression to AD. Methods: 79 MCIa patients and 138 healthy controls were analyzed. SNPs were...

... neurons. Biol Pharm Bull 2010;33:1165–1169. 11. Wenham PR, Price WH, Blandell G: Apolipoprotein E genotyping by one-stage PCR. Lancet 1991;337:1158–1159. 12. Ando T, Komaki G, Naruo T, Okabe K, Takii M, Kawai K, Konjiki F, Takei M, Oka T, Takeuchi K, Masuda A, Ozaki N, Suematsu H, Denda K...

...Miika Vuorinen; Alina Solomon; Suvi Rovio; Lasse Nieminen; Ingemar Kåreholt; Jaakko Tuomilehto; Hilkka Soininen; Miia Kivipelto Background/Aims: This study investigated the relation of midlife blood pressure, total cholesterol, body mass index (BMI), their changes over time, apolipoprotein E...

... of dementia, Alzheimer’s disease (AD) and vascular dementia (VaD) are common and widely studied. We evaluated the role of apolipoprotein E (ApoE) and interleukin-6 (IL-6)–174 G/C gene polymorphism along with serum IL-6 levels in AD and VaD patients. Methods: The polymorphisms in ApoE and IL-6–174 G/C genes...

...Oh Dae Kwon; Aisha Khaleeq; Wenyaw Chan; Valory N. Pavlik; Rachelle S. Doody Background: The relationship between the apolipoprotein E (ApoE) genotype and the risk for developing Alzheimer’s disease (AD) or age at onset of AD is relatively well established in Caucasians, but less established...

...Sheila Crean; Alex Ward; Catherine J. Mercaldi; Jenna M. Collins; Michael N. Cook; Nicole L. Baker; H. Michael Arrighi Background: The Ε4 allele of apolipoprotein E (APOE) is associated with Alzheimer’s disease (AD). However, attributable risk due to APOE4 varies by region and by race/ethnicity...

...M. Rusanen; S. Rovio; T. Ngandu; A. Nissinen; J. Tuomilehto; H. Soininen; M. Kivipelto Aim: To elucidate the effect of midlife smoking on the risk of dementia and Alzheimer’s disease (AD), and the possible modification of this relation by the apolipoprotein E (APOE) Ε4. Methods: Participants...

... of PLTP in brain tissue and significantly lower PLTP-mediated phospholipid transfer activity in cerebrospinal fluid. PLTP also affects apolipoprotein E (APOE) secretion from glial cells. This study aimed to investigate whether single nucleotide polymorphisms (SNPs) of the PLTP gene are associated with AD...

... (rpAD). Methods: Retrospective analyses of 32 neuropathologically confirmed cases differentially diagnosed as AD out of a group with rapidly progressive dementia. CSF biomarkers (14-3-3, tau, β-amyloid 1–42) and genetic markers ( PRNP codon 129, apolipoprotein E, ApoE, polymorphism) were determined...

...Leticia Gutiérrez-Galve; Manja Lehmann; Nicola Z. Hobbs; Matthew J. Clarkson; Gerard R. Ridgway; Sebastian Crutch; Sebastien Ourselin; Jonathan M. Schott; Nick C. Fox; Josephine Barnes Background: Possession of one or more apolipoprotein E (APOE) ε4 alleles may influence the distribution of atrophy...

... including a haplotype analysis. Furthermore, an analysis of the cases divided according to apolipoprotein E (APO E) status was also carried out. Our case-control dataset consists of 181 AD patients and 130 age-matched controls. Results: Although none of the SNPs showed statistically significant association...

...Ágnes Fehér; Anna Juhász; Ágnes Rimanóczy; Éva Csibri; János Kálmán; Zoltán Janka We tested the hypothesis whether the partially duplicated variant of α7 nicotinic acetylcholine receptor subunit gene (CHRFAM7A) 2-bp deletion (–2 bp) polymorphism and apolipoprotein E (ApoE) ε4 allele confer...