... and the Alzheimer’s Association criteria for preclinical AD proposed that subtle cognitive changes appear along with AD biomarkers in the late stage of preclinical AD. The objective of this study was to explore whether subtle cognitive impairment (SCI) in individuals with SCD is associated with brain amyloid-β (Aβ...

... the pathology and disease progression are essential for diagnosis and are important when developing new therapies. Today, the core protein biomarkers amyloid-β 42 , total tau and phosphorylated tau in the cerebrospinal fluid (CSF) are used to diagnose Alzheimer's disease (AD), because these biomarkers have...

..., instructions or products referred to in the content or advertisements. Early-onset Alzheimer’s disease APP gene Amyloid-β Mutation Val717Ile Iran Alzheimer's disease (AD) is a progressive neurodegenerative disease, which affected more than 35 million individuals worldwide in 2010...

...) and Parkinson's disease with dementia (PDD). This study aimed to evaluate whether the cerebrospinal fluid (CSF) amyloid-β (Aβ) 1-42 /Aβ 1-40 ratio, measured by a novel method, could improve the differential diagnosis of AD, DLB and PDD. Method: CSF levels of Aβ 1-40 and Aβ 1-42 in patients with PDD, DLB, AD...

... to in the content or advertisements. Alzheimer’s disease Mild cognitive impairment Biomarkers Cerebrospinal fluid Tau Phospho-tau Amyloid-β Apolipoprotein E Disease progression Original Research Article Dement Geriatr Cogn Disord 2009;27:458 464 DOI: 10.1159/000216841 Accepted: January 30, 2009...

... trying to elucidate early events in AD pathogenesis. Aim: To investigate how levels of different amyloid-β (Aβ) peptides, as well as tau and phosphorylated tau, in cerebrospinal fluid (CSF) from children with DS change over time. The first CSF sample was taken at 8 months and the following two samples...

..., instructions or products referred to in the content or advertisements. Butyrylcholinesterase K genotype Alzheimer’s disease Dementia with Lewy bodies Phosphorylated tau Amyloid-β Temporal cortex Original Research Article Dement Geriatr Cogn Disord 2005;19:357 360 DOI: 10.1159/000084705 Accepted...

... in Alzheimer’s disease (AD), little is known about the role of antigen-specific immune responses. We investigated T cell reactivity to fragment 1–42 of amyloid-β (Aβ) and to N-terminal peptides of human mitochondrial and control microbial proteins. Thirty subjects with a diagnosis of probable AD according...