... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. ADAM10 Alzheimer’s disease Amyloid precursor protein Elderly people Platelets α-Secretase Alzheimer’s...

... differences. Familial Alzheimer’s disease Familial autosomal dominant Alzheimer’s disease Presenilin Amyloid precursor protein Hippocampal atrophy Cortical atrophy Mutation carriers National Institutes of Health (NIH) 10.13039/100000002 Familial autosomal dominant Alzheimer’s...

.... Presenilin 1 Amyloid precursor protein Early-onset Alzheimer’s disease Preclinical dementia Alzheimer’s disease Linguistic ability National Institutes of Health (NIH) 10.13039/100000002 The Nun Study identified a connection between literacy in early life and memory decline in late...

...-1 (PSEN1) gene on chromosome 14 [2]. Second most common are changes in the Amyloid Precursor Protein (APP) gene on chromosome 21 [3] and rarest are mutations in Fax +41 61 306 12 34 E-Mail [email protected] www.karger.com © 2008 S. Karger AG, Basel Accessible online at: www.karger.com/dem John...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Amyloid precursor protein...

...H.C. Liu; C.W. Chi; S.Y. Ko; H.C. Wang; C.J. Hong; K.N. Lin; P.N. Wang; T.Y. Liu An altered platelet ratio of amyloid precursor protein (APP) isoforms might be a diagnostic, predictive, or therapeutic marker for Alzheimer’s disease (AD). Our purpose was to test the hypothesis that this ratio might...

...K. Höglund; K.M. Thelen; S. Syversen; M. Sjögren; K. von Bergmann; A. Wallin; E. Vanmechelen; H. Vanderstichele; D. Lütjohann; K. Blennow During the last years, several clinical studies have been published trying to elucidate the effect of statin treatment on amyloid precursor protein (APP...

... for 12 weeks in an open trial. Primary efficacy parameters were the changes after 12 weeks in the cerebrospinal fluid (CSF) levels of β-amyloid 42 (Aβ 42 ), α-secretase-cleaved amyloid precursor protein (α-sAPP), β-secretase-cleaved APP (β-sAPP), tau, phospho-tau and the plasma levels of Aβ 42...

...Pia Davidsson; Nenad Bogdanovic; Lars Lannfelt; Kaj Blennow To study the role of amyloid precursor protein (APP) in the pathogenesis of Alzheimer’s disease (AD), the level of APP was analysed by quantitative immunoblotting in 6 AD patients and 6 age-matched controls in 9 brain regions. These were...

...A. Savioz; G. Leuba; C. Forsell; L. Lilius; C. Rossier; K. Saini; C. Bouras; L. Lannfelt Mutations have been found in more than a hundred early-onset families with Alzheimer’s disease (AD) in the genes for the amyloid precursor protein, presenilin 1 and presenilin 2. The object of our investigation...

... OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO Key Words Prevalence Epidemiological study Dementia of the Alzheimer type Apolipoprotein E Amyloid precursor protein Presenilin OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO Abstract We carried out two separate epidemiological studies on long...