Aims: To examine the association of a reported tendency toward repetitive thinking (RT) in midlife when confronting difficulties in family and work settings with dementia many years later. Methods: A tendency toward RT was assessed in approximately 9,000 male participants in the Israeli Ischemic Heart Disease study in 1965. The subjects were categorized according to their tendency toward RT in familial and work settings as: 1 = always forget; 2 = tend to forget; 3 = tend to think repetitively, and 4 = usually think repetitively. Dementia was assessed over 3 decades later in 1,889 participants among 2,604 survivors of the original cohort. Results: The prevalence rates of dementia were 24, 19, 15 and 14% in the 4 groups of tendency toward RT in stressful work situations with superiors (p for trend < 0.0002), respectively. The prevalence rates of dementia were 21, 18, 14 and 14% in the 4 groups of tendency toward RT in familial situations (p for trend < 0.004), respectively. These associations held after multivariate analysis. Conclusions: The tendency toward RT when confronting distress is associated with a lower risk for dementia. Future studies should assess possible mechanisms and potentials for intervention and modification.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.