Introduction: Sleep duration is proposed as a lifestyle-related risk factor for cognitive impairment. We investigated the association between sleep duration and cognitive function in a large population-based cohort aged 62–65 years. Methods: Cross-sectional analyses from the Akershus Cardiac Examination 1950 Study. Linear and nonlinear models were conducted to explore the association between self-reported sleep duration and cognitive function, adjusted for established risk factors for cognitive impairment. Results: We included 3,348 participants, mean age (SD) was 63.9 ± 0.6 years, 48.2% were women, and 47.9% had education >12 years. Mean sleep duration (SD) was 7.0 ± 1.0 h, and 10.2% had abnormal sleep duration (<6 or >8 h). Individuals reporting <6 h or >8 h of sleep scored significantly lower on MoCA test and delayed recall trial in adjusted analysis. Conclusions: Sleep duration showed an inverted U-shaped association with global cognitive function and memory, suggesting that both shortened and prolonged sleep are related to adverse brain health.

1.
Wang
Z
,
Yang
W
,
Li
X
,
Qi
X
,
Pan
KY
,
Xu
W
.
Association of sleep duration, napping, and sleep patterns with risk of cardiovascular diseases: a nationwide twin study
.
J Am Heart Assoc
.
2022
;
11
(
15
):
e025969
.
2.
Kip
E
,
Parr-Brownlie
LC
.
Healthy lifestyles and wellbeing reduce neuroinflammation and prevent neurodegenerative and psychiatric disorders
.
Front Neurosci
.
2023
;
17
:
1092537
.
3.
García-García
I
,
Donica
O
,
Cohen
AA
,
Gonseth Nusslé
S
,
Heini
A
,
Nusslé
S
, et al
.
Maintaining brain health across the lifespan
.
Neurosci Biobehav Rev
.
2023
;
153
:
105365
.
4.
Lloyd-Jones
DM
,
Allen
NB
,
Anderson
CAM
,
Black
T
,
Brewer
LC
,
Foraker
RE
, et al
.
Life’s essential 8: updating and enhancing the American heart association’s construct of cardiovascular health: a presidential advisory from the American heart association
.
Circulation
.
2022
;
146
(
5
):
e18
43
.
5.
Turrini
S
,
Wong
B
,
Eldaief
M
,
Press
DZ
,
Sinclair
DA
,
Koch
G
, et al
.
The multifactorial nature of healthy brain ageing: brain changes, functional decline and protective factors
.
Ageing Res Rev
.
2023
;
88
:
101939
.
6.
Robbins
R
,
Quan
SF
,
Weaver
MD
,
Bormes
G
,
Barger
LK
,
Czeisler
CA
.
Examining sleep deficiency and disturbance and their risk for incident dementia and all-cause mortality in older adults across 5 years in the United States
.
Aging
.
2021
;
13
(
3
):
3254
68
.
7.
Gottesman
RF
,
Lutsey
PL
,
Benveniste
H
,
Brown
DL
,
Full
KM
,
Lee
JM
, et al
.
Impact of sleep disorders and disturbed sleep on brain health: a scientific statement from the American heart association
.
Stroke
.
2024
;
55
(
3
):
e61
76
.
8.
Ma
Y
,
Liang
L
,
Zheng
F
,
Shi
L
,
Zhong
B
,
Xie
W
.
Association between sleep duration and cognitive decline
.
JAMA Netw Open
.
2020
;
3
(
9
):
e2013573
.
9.
Yaffe
K
,
Falvey
CM
,
Hoang
T
.
Connections between sleep and cognition in older adults
.
Lancet Neurol
.
2014
;
13
(
10
):
1017
28
.
10.
Kumar
M
,
Orkaby
A
,
Tighe
C
,
Villareal
DT
,
Billingsley
H
,
Nanna
MG
, et al
.
Life’s essential 8: optimizing health in older adults
.
JACC Adv
.
2023
;
2
(
7
):
100560
.
11.
López-Otín
C
,
Blasco
MA
,
Partridge
L
,
Serrano
M
,
Kroemer
G
.
Hallmarks of aging: an expanding universe
.
Cell
.
2023
;
186
(
2
):
243
78
.
12.
Sabia
S
,
Fayosse
A
,
Dumurgier
J
,
van Hees
VT
,
Paquet
C
,
Sommerlad
A
, et al
.
Association of sleep duration in middle and old age with incidence of dementia
.
Nat Commun
.
2021
;
12
(
1
):
2289
.
13.
Lo
JC
,
Groeger
JA
,
Cheng
GH
,
Dijk
DJ
,
Chee
MWL
.
Self-reported sleep duration and cognitive performance in older adults: a systematic review and meta-analysis
.
Sleep Med
.
2016
;
17
:
87
98
.
14.
Loerbroks
A
,
Debling
D
,
Amelang
M
,
Stürmer
T
.
Nocturnal sleep duration and cognitive impairment in a population-based study of older adults
.
Int J Geriatr Psychiatry
.
2010
;
25
(
1
):
100
9
.
15.
Sindi
S
,
Kåreholt
I
,
Johansson
L
,
Skoog
J
,
Sjöberg
L
,
Wang
HX
, et al
.
Sleep disturbances and dementia risk: a multicenter study
.
Alzheimers Dement
.
2018
;
14
(
10
):
1235
42
.
16.
Xie
L
,
Kang
H
,
Xu
Q
,
Chen
MJ
,
Liao
Y
,
Thiyagarajan
M
, et al
.
Sleep drives metabolite clearance from the adult brain
.
Science
.
2013
;
342
(
6156
):
373
7
.
17.
Cirelli
C
,
Tononi
G
.
The why and how of sleep-dependent synaptic down-selection
.
Semin Cell Dev Biol
.
2022
;
125
:
91
100
.
18.
Livingston
G
,
Huntley
J
,
Sommerlad
A
,
Ames
D
,
Ballard
C
,
Banerjee
S
, et al
.
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
.
Lancet
.
2020
;
396
(
10248
):
413
46
.
19.
Berge
T
,
Vigen
T
,
Pervez
MO
,
Ihle-Hansen
H
,
Lyngbakken
MN
,
Omland
T
, et al
.
Heart and brain interactions: the Akershus cardiac examination (ACE) 1950 study design
.
Scand Cardiovasc J
.
2015
;
49
(
6
):
308
15
.
20.
Zigmond
AS
,
Snaith
RP
.
The hospital anxiety and depression scale
.
Acta Psychiatr Scand
.
1983
;
67
(
6
):
361
70
.
21.
Nasreddine
ZS
,
Phillips
NA
,
Bédirian
V
,
Charbonneau
S
,
Whitehead
V
,
Collin
I
, et al
.
The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment
.
J Am Geriatr Soc
.
2005
;
53
(
4
):
695
9
.
22.
Morris
JC
,
Heyman
A
,
Mohs
RC
,
Hughes
JP
,
van Belle
G
,
Fillenbaum
G
, et al
.
The consortium to establish a registry for alzheimer’s disease (CERAD). Part I. Clinical and neuropsychological assessment of alzheimer’s disease
.
Neurology
.
1989
;
39
(
9
):
1159
65
.
23.
Reitan
RM
.
Validity of the Trail Making Test as an indicator of organic brain damage
.
Percept Mot Skills
.
1958
;
8
(
7
):
271
6
.
24.
Blackwell
T
,
Yaffe
K
,
Laffan
A
,
Ancoli-Israel
S
,
Redline
S
,
Ensrud
KE
, et al
.
Associations of objectively and subjectively measured sleep quality with subsequent cognitive decline in older community-dwelling men: the MrOS sleep study
.
Sleep
.
2014
;
37
(
4
):
655
63
.
25.
Mantua
J
,
Simonelli
G
.
Sleep duration and cognition: is there an ideal amount
.
Sleep
.
2019
;
42
(
3
):
zsz010
.
26.
Chen
JC
,
Espeland
MA
,
Brunner
RL
,
Lovato
LC
,
Wallace
RB
,
Leng
X
, et al
.
Sleep duration, cognitive decline, and dementia risk in older women
.
Alzheimers Dement
.
2016
;
12
(
1
):
21
33
.
27.
Kivipelto
M
,
Solomon
A
,
Ahtiluoto
S
,
Ngandu
T
,
Lehtisalo
J
,
Antikainen
R
, et al
.
The Finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER): study design and progress
.
Alzheimers Dement
.
2013
;
9
(
6
):
657
65
.
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