Introduction: Stroke is common cerebrovascular disease in the elderly, which is characterized by neurological defects caused by cerebral vessels. Multiple studies have shown that miRNAs play important roles in stroke. In addition, a large number of evidence suggest that stroke increases the risk and severity of cognitive impairments. Methods: miR-511-3p expression levels were detected by real-time PCR. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic value of miR-511-3p in distinguishing stroke patients from healthy controls and to assess risk of post-stroke cognitive impairment (PSCI) in stroke patients. Pearson correlation coefficient was used to determine the relationship between miR-511-3p expression level and Montreal Cognitive Assessment Scale (MoCA) scores. Results: Serum miR-511-3p expression levels were decreased in stroke patients, and the decrease was more significant in PSCI patients. ROC curve results showed that miR-511-3p had high diagnostic accuracy in distinguishing healthy controls from stroke patients. Moreover, the expression level of miR-511-3p can be used as an independent predictor for the occurrence of PSCI and is positively correlated with MoCA scores of PSCI patients. Conclusion: miR-511-3p may be involved in the occurrence and development of stroke. In addition, miR-511-3p may be a novel biomarker for predicting PSCI occurred in stroke patients. These results may help improve the quality of prognosis of stroke.

1.
Wei
G
,
Ji
X
,
Bai
H
,
Ding
Y
.
Stroke research in China
.
Neurol Res
.
2006
;
28
(
1
):
11
5
.
2.
Shehjar
F
,
Maktabi
B
,
Rahman
ZA
,
Bahader
GA
,
James
AW
,
Naqvi
A
et al
.
Stroke: molecular mechanisms and therapies: update on recent developments
.
Neurochem Int
.
2023
;
162
:
105458
.
3.
Tay
J
,
Morris
RG
,
Markus
HS
.
Apathy after stroke: diagnosis, mechanisms, consequences, and treatment
.
Int J Stroke
.
2021
;
16
(
5
):
510
8
.
4.
Lee
EC
,
Ha
TW
,
Lee
DH
,
Hong
DY
,
Park
SW
,
Lee
JY
et al
.
Utility of exosomes in ischemic and hemorrhagic stroke diagnosis and treatment
.
Int J Mol Sci
.
2022
;
23
(
15
):
8367
.
5.
Herpich
F
,
Rincon
F
.
Management of acute ischemic stroke
.
Crit Care Med
.
2020
;
48
(
11
):
1654
63
.
6.
Ohashi
SN
,
DeLong
JH
,
Kozberg
MG
,
Mazur-Hart
DJ
,
van Veluw
SJ
,
Alkayed
NJ
et al
.
Role of inflammatory processes in hemorrhagic stroke
.
Stroke
.
2023
;
54
(
2
):
605
19
.
7.
Schumacher
R
,
Halai
AD
,
Lambon Ralph
MA
.
Assessing and mapping language, attention and executive multidimensional deficits in stroke aphasia
.
Brain
.
2019
;
142
(
10
):
3202
16
.
8.
Shen
W
,
Fan
X
,
Wang
L
,
Zhang
Y
.
Traditional Chinese medicine for post-stroke cognitive impairment: a systematic review and meta-analysis
.
Front Pharmacol
.
2022
;
13
:
816333
.
9.
Le Danseur
M
.
Stroke rehabilitation
.
Crit Care Nurs Clin North Am
.
2020
;
32
(
1
):
97
108
.
10.
Rost
NS
,
Brodtmann
A
,
Pase
MP
,
van Veluw
SJ
,
Biffi
A
,
Duering
M
et al
.
Post-stroke cognitive impairment and dementia
.
Circ Res
.
2022
;
130
(
8
):
1252
71
.
11.
Ciesielska
N
,
Sokolowski
R
,
Mazur
E
,
Podhorecka
M
,
Polak-Szabela
A
,
Kedziora-Kornatowska
K
.
Is the Montreal Cognitive Assessment (MoCA) test better suited than the Mini-Mental State Examination (MMSE) in mild cognitive impairment (MCI) detection among people aged over 60? Meta-analysis
.
Psychiatr Pol
.
2016
;
50
(
5
):
1039
52
.
12.
Zheng
D
,
Sabbagh
JJ
,
Blair
LJ
,
Darling
AL
,
Wen
X
,
Dickey
CA
.
MicroRNA-511 binds to FKBP5 mRNA, which encodes a chaperone protein, and regulates neuronal differentiation
.
J Biol Chem
.
2016
;
291
(
34
):
17897
906
.
13.
Karagiannis
GS
,
Weile
J
,
Bader
GD
,
Minta
J
.
Integrative pathway dissection of molecular mechanisms of moxLDL-induced vascular smooth muscle phenotype transformation
.
BMC Cardiovasc Disord
.
2013
;
13
:
4
.
14.
Jia
YM
,
Zhu
CF
,
She
ZY
,
Wu
MM
,
Wu
YY
,
Zhou
BY
et al
.
Effects on autophagy of moxibustion at governor vessel acupoints in APP/PS1double-transgenic Alzheimer’s disease mice through the lncRNA six3os1/miR-511-3p/AKT3 molecular Axis
.
Evid Based Complement Alternat Med
.
2022
;
2022
:
3881962
.
15.
Zhou
Y
,
Do
DC
,
Ishmael
FT
,
Squadrito
ML
,
Tang
HM
,
Tang
HL
et al
.
Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p
.
J Allergy Clin Immunol
.
2018
;
141
(
1
):
350
64.e8
.
16.
Zou
T
,
Sugimoto
K
,
Zhang
J
,
Liu
Y
,
Zhang
Y
,
Liang
H
et al
.
Geniposide alleviates oxidative stress of mice with depression-like behaviors by upregulating Six3os1
.
Front Cell Dev Biol
.
2020
;
8
:
553728
.
17.
Panni
P
,
Gory
B
,
Xie
Y
,
Consoli
A
,
Desilles
JP
,
Mazighi
M
et al
.
Acute stroke with large ischemic core treated by thrombectomy
.
Stroke
.
2019
;
50
(
5
):
1164
71
.
18.
Fava
GA
,
Kellner
R
,
Munari
F
,
Pavan
L
.
The Hamilton depression rating scale in normals and depressives
.
Acta Psychiatr Scand
.
1982
;
66
(
1
):
26
32
.
19.
Shi
D
,
Chen
X
,
Li
Z
.
Diagnostic test accuracy of the Montreal Cognitive Assessment in the detection of post-stroke cognitive impairment under different stages and cutoffs: a systematic review and meta-analysis
.
Neurol Sci
.
2018
;
39
(
4
):
705
16
.
20.
Gandjour
A
,
Gafni
A
.
Internal validation of models with several interventions
.
Eur J Health Econ
.
2013
;
14
(
6
):
901
9
.
21.
Komlodi-Pasztor
E
,
Gilbert
MR
,
Armstrong
TS
.
Diagnosis and management of stroke in adults with primary brain tumor
.
Curr Oncol Rep
.
2022
;
24
(
10
):
1251
9
.
22.
Huang
YY
,
Chen
SD
,
Leng
XY
,
Kuo
K
,
Wang
ZT
,
Cui
M
et al
.
Post-stroke cognitive impairment: epidemiology, risk factors, and management
.
J Alzheimers Dis
.
2022
;
86
(
3
):
983
99
.
23.
Oliveira
FAA
,
Sampaio Rocha-Filho
PA
.
Headaches attributed to ischemic stroke and transient ischemic attack
.
Headache
.
2019
;
59
(
3
):
469
76
.
24.
Pandian
JD
,
Gall
SL
,
Kate
MP
,
Silva
GS
,
Akinyemi
RO
,
Ovbiagele
BI
et al
.
Prevention of stroke: a global perspective
.
Lancet
.
2018
;
392
(
10154
):
1269
78
.
25.
Toman
NG
,
Grande
AW
,
Low
WC
.
Neural repair in stroke
.
Cell Transplant
.
2019
28
9–10
1123
6
.
26.
Fonseca
AC
,
Ferro
JM
.
Cryptogenic stroke
.
Eur J Neurol
.
2015
;
22
(
4
):
618
23
.
27.
Kim
H
,
Seo
JS
,
Lee
SY
,
Ha
KT
,
Choi
BT
,
Shin
YI
et al
.
AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice
.
Brain Behav Immun
.
2020
;
87
:
765
76
.
28.
Saliminejad
K
,
Khorram Khorshid
HR
,
Soleymani Fard
S
,
Ghaffari
SH
.
An overview of microRNAs: biology, functions, therapeutics, and analysis methods
.
J Cell Physiol
.
2019
;
234
(
5
):
5451
65
.
29.
Wang
J
,
Chen
S
,
Zhang
W
,
Chen
Y
,
Bihl
JC
.
Exosomes from miRNA-126-modified endothelial progenitor cells alleviate brain injury and promote functional recovery after stroke
.
CNS Neurosci Ther
.
2020
;
26
(
12
):
1255
65
.
30.
Vijayan
M
,
Alamri
FF
,
Al Shoyaib
A
,
Karamyan
VT
,
Reddy
PH
.
Novel miRNA PC-5P-12969 in ischemic stroke
.
Mol Neurobiol
.
2019
;
56
(
10
):
6976
85
.
31.
Kondybayeva
А
,
Akimniyazova
A
,
Kamenova
S
,
Duchshanova
G
,
Aisina
D
,
Goncharova
A
et al
.
Prediction of miRNA interaction with mRNA of stroke candidate genes
.
Neurol Sci
.
2020
;
41
(
4
):
799
808
.
32.
Yu
L
,
Liao
Q
,
Zeng
X
,
Lv
Z
,
Zheng
H
,
Zhao
Y
et al
.
MicroRNA expressions associated with eosinophilic meningitis caused by Angiostrongylus cantonensis infection in a mouse model
.
Eur J Clin Microbiol Infect Dis
.
2014
;
33
(
8
):
1457
65
.
33.
Hshieh
TT
,
Inouye
SK
,
Oh
ES
.
Delirium in the elderly
.
Psychiatr Clin North Am
.
2018
;
41
(
1
):
1
17
.
34.
Fong
TG
,
Inouye
SK
.
The inter-relationship between delirium and dementia: the importance of delirium prevention
.
Nat Rev Neurol
.
2022
;
18
(
10
):
579
96
.
35.
Lyketsos
CG
,
Carrillo
MC
,
Ryan
JM
,
Khachaturian
AS
,
Trzepacz
P
,
Amatniek
J
et al
.
Neuropsychiatric symptoms in Alzheimer’s disease
.
Alzheimers Dement
.
2011
;
7
(
5
):
532
9
.
36.
Benedict
RHB
,
Amato
MP
,
DeLuca
J
,
Geurts
JJG
.
Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues
.
Lancet Neurol
.
2020
;
19
(
10
):
860
71
.
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