Abstract
Background/Aims: With rising elderly populations, age-related health problems such as cognitive impairment and dementia are major public health concerns. We sought to assess the prevalence of cognitive impairment and associated factors in rural elderly Cameroonians. Methods: The Mini Mental State Examination was used to assess the cognitive function of participants randomly recruited during a house-to-house survey of the Batibo Health District. Results: The prevalence of cognitive impairment in our study was 33.3%. Increasing age, female gender, being single, a lack of formal education, and higher systolic blood pressure values were significantly and independently associated with cognitive impairment. Conclusion: The identification of modifiable factors would inform evidence-based policy to decrease the health and social burdens of cognitive impairment and dementia in the elderly in rural Cameroon.
References
1.
Mavrodaris
A
, Powell
J
, Thorogood
M
. Prevalences of dementia and cognitive impairment among older people in sub-Saharan Africa: a systematic review
. Bull World Health Organ
. 2013
Oct
;91
(10
):773
–83
.
[PubMed]
0042-96862.
United
N
. World Population Ageing 2015 - Highlights. New York; 2015
. http://www.un.org/en/development/desa/population/publications/pdf/ageing/WPA2015_Highlights.pdf3.
Tianyi
FL
, Agbor
VN
, Njamnshi
AK
. Prevalence, awareness, treatment, and control of hypertension in Cameroonians aged 50 years and older: A community-based study
. Health Sci Rep
. 2018
Apr
;1
(5
):e44
.
[PubMed]
2398-88354.
Gauld
R
, Blank
R
, Burgers
J
, Cohen
AB
, Dobrow
M
, Ikegami
N
, et al. The World Health Report 2008 - Primary Healthcare: How Wide Is the Gap between Its Agenda and Implementation in 12 High-Income Health Systems?
Healthc Policy
. 2012
Feb
;7
(3
):38
–58
.
[PubMed]
1715-65725.
Brhlikova
P
, Pollock
AM
, Manners
R
. Global Burden of Disease estimates of depression—how reliable is the epidemiological evidence?
J R Soc Med
. 2011
Jan
;104
(1
):25
–34
.
[PubMed]
0141-07686.
Brodaty
H
, Connors
MH
, Ames
D
, Woodward
M
; PRIME study group
. Progression from mild cognitive impairment to dementia: a 3-year longitudinal study
. Aust N Z J Psychiatry
. 2014
Dec
;48
(12
):1137
–42
.
[PubMed]
0004-86747.
Albert
MS
, DeKosky
ST
, Dickson
D
, Dubois
B
, Feldman
HH
, Fox
NC
, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease
. Alzheimers Dement
. 2011
May
;7
(3
):270
–9
.
[PubMed]
1552-52608.
Wortmann
M
. Dementia: a global health priority - highlights from an ADI and World Health Organization report
. Alzheimers Res Ther
. 2012
Sep
;4
(5
):40
.
[PubMed]
1758-91939.
Cameroon's, National, Institute, of, Statistics. Chapter 4: Characteristics of the population. Statistics year book 2010.;
2011
:39-52.10.
Folstein
MF
, Folstein
SE
, McHugh
PR
. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician
. J Psychiatr Res
. 1975
Nov
;12
(3
):189
–98
.
[PubMed]
0022-395611.
Pezzotti
P
, Scalmana
S
, Mastromattei
A
, Di Lallo
D
; Progetto Alzheimer Working Group
. The accuracy of the MMSE in detecting cognitive impairment when administered by general practitioners: a prospective observational study
. BMC Fam Pract
. 2008
May
;9
(1
):29
.
[PubMed]
1471-229612.
Gugssa
SA
, Davey
G
, Ejigu
AA
, Metaferia
GZ
, Medhin
G
, Kelkile
TS
. Population norms for the mini-mental state examination in Ethiopia
. Ethiop Med J
. 2011
Jul
;49
(3
):239
–47
.
[PubMed]
0014-175513.
Kowal
P
, Peachey
K
. Indicators for the minimum data set project on ageing: a critical review in sub-Saharan Africa.
Dar es Salaam, United Republic of Tanzania: WHO. 2001
;9.14.
Beamish
AJ
, Olbers
T
, Kelly
AS
, Inge
TH
. Cardiovascular effects of bariatric surgery
. Nat Rev Cardiol
. 2016
Dec
;13
(12
):730
–43
.
[PubMed]
1759-500215.
Bursac
ZG
, C.H.; Williams, D.K.; Hosmer, D.W. Purposeful selection of variables in logistic regression. Source Code Biol Med:BMC. 2008
;3(17).16.
Vatcheva
KP
, Lee
M
, McCormick
JB
, Rahbar
MH
. Multicollinearity in Regression Analyses Conducted in Epidemiologic Studies
. Epidemiology (Sunnyvale)
. 2016
Apr
;6
(2
):227
.
[PubMed]
2161-116517.
Guerchet
M
, Mouanga
AM
, M’belesso
P
, Tabo
A
, Bandzouzi
B
, Paraïso
MN
, et al. Factors associated with dementia among elderly people living in two cities in Central Africa: the EDAC multicenter study
. J Alzheimers Dis
. 2012
;29
(1
):15
–24
.
[PubMed]
1387-287718.
Choi
SJJ
, S.; You, Y.S.; Shin, B.S.; Kim, J.E.; Yoon, S.W. Prevalence of Alzheimer’s dementia and its risk factors in communitydwelling elderly Koreans. Psychiatry Invest. 2008
(5):78-85.19.
Boyle
PA
, Wilson
RS
, Aggarwal
NT
, Tang
Y
, Bennett
DA
. Mild cognitive impairment: risk of Alzheimer disease and rate of cognitive decline
. Neurology
. 2006
Aug
;67
(3
):441
–5
.
[PubMed]
0028-387820.
Guerchet
M
, Houinato
D
, Paraiso
MN
, von Ahsen
N
, Nubukpo
P
, Otto
M
, et al. Cognitive impairment and dementia in elderly people living in rural Benin, west Africa
. Dement Geriatr Cogn Disord
. 2009
;27
(1
):34
–41
.
[PubMed]
1420-800821.
Uwakwe
R
. The pattern of psychiatric disorders among the aged in a selected community in Nigeria
. Int J Geriatr Psychiatry
. 2000
Apr
;15
(4
):355
–62
.
[PubMed]
0885-623022.
Artero
S
, Ancelin
ML
, Portet
F
, Dupuy
A
, Berr
C
, Dartigues
JF
, et al. Risk profiles for mild cognitive impairment and progression to dementia are gender specific
. J Neurol Neurosurg Psychiatry
. 2008
Sep
;79
(9
):979
–84
.
[PubMed]
0022-305023.
Parker
C
, Philp
I
. Screening for cognitive impairment among older people in black and minority ethnic groups
. Age Ageing
. 2004
Sep
;33
(5
):447
–52
.
[PubMed]
0002-072924.
Ramlall
S
, Chipps
J
, Bhigjee
AL
, Pillay
BJ
. Screening a heterogeneous elderly South African population for cognitive impairment: the utility and performance of the Mini- Mental State Examination, Six Item Screener, Subjective Memory Rating Scale and Deterioration Cognitive Observee
. Afr J Psychiatry (Johannesbg)
. 2013
Nov
;16
(6
).
[PubMed]
1994-822025.
Crum
RM
, Anthony
JC
, Bassett
SS
, Folstein
MF
. Population-based norms for the Mini-Mental State Examination by age and educational level
. JAMA
. 1993
May
;269
(18
):2386
–91
.
[PubMed]
0098-748426.
Kochhann
R
, Varela
JS
, Lisboa
CS
, Chaves
ML
. The Mini Mental State Examination: review of cutoff points adjusted for schooling in a large Southern Brazilian sample
. Dement Neuropsychol
. 2010
Jan-Mar
;4
(1
):35
–41
.
[PubMed]
1980-576427.
Narushima
K
, Chan
KL
, Kosier
JT
, Robinson
RG
. Does cognitive recovery after treatment of poststroke depression last? A 2-year follow-up of cognitive function associated with poststroke depression
. Am J Psychiatry
. 2003
Jun
;160
(6
):1157
–62
.
[PubMed]
0002-953X28.
Patel
M
, Coshall
C
, Rudd
AG
, Wolfe
CD
. Natural history of cognitive impairment after stroke and factors associated with its recovery
. Clin Rehabil
. 2003
Mar
;17
(2
):158
–66
.
[PubMed]
0269-215529.
Alex
JM
. The Mini-Mental State Examination (MMSE) (2013
). An Update on Its Diagnostic Validity for Cognitive Disorders 2013.30.
Clausen
T
, Romøren
TI
, Ferreira
M
, Kristensen
P
, Ingstad
B
, Holmboe-Ottesen
G
. Chronic diseases and health inequalities in older persons in Botswana (southern Africa): a national survey
. J Nutr Health Aging
. 2005
Nov-Dec
;9
(6
):455
–61
.
[PubMed]
1279-770731.
Sunwoo
MK
, Jeon
S
, Ham
JH
, Hong
JY
, Lee
JE
, Lee
JM
, et al. The burden of white matter hyperintensities is a predictor of progressive mild cognitive impairment in patients with Parkinson’s disease
. Eur J Neurol
. 2014
Jun
;21
(6
):922
–e50
.
[PubMed]
1351-510132.
Myers
JS
. Factors associated with changing cognitive function in older adults: implications for nursing rehabilitation
. Rehabil Nurs
. 2008
May-Jun
;33
(3
):117
–23
.
[PubMed]
0278-480733.
Ogunniyi
A
, Gureje
O
, Baiyewu
O
, Unverzagt
F
, Hall
KS
, Oluwole
S
, et al. Profile of dementia in a Nigerian community—types, pattern of impairment, and severity rating
. J Natl Med Assoc
. 1997
Jun
;89
(6
):392
–6
.
[PubMed]
0027-968434.
Borenstein
AR
, Copenhaver
CI
, Mortimer
JA
. Early-life risk factors for Alzheimer disease
. Alzheimer Dis Assoc Disord
. 2006
Jan-Mar
;20
(1
):63
–72
.
[PubMed]
0893-034135.
Li
R
, Singh
M
. Sex differences in cognitive impairment and Alzheimer’s disease
. Front Neuroendocrinol
. 2014
Aug
;35
(3
):385
–403
.
[PubMed]
0091-302236.
Laws
KR
, Irvine
K
, Gale
TM
. Sex differences in cognitive impairment in Alzheimer’s disease
. World J Psychiatry
. 2016
Mar
;6
(1
):54
–65
.
[PubMed]
2220-320637.
Tembon
MM
, Fort
L
. Girl’s education in the 21st century: Gender equality, empowerment and growth
. The World Bank
; 2008
. 38.
Fratiglioni
L
, Wang
HX
, Ericsson
K
, Maytan
M
, Winblad
B
. Influence of social network on occurrence of dementia: a community-based longitudinal study
. Lancet
. 2000
Apr
;355
(9212
):1315
–9
.
[PubMed]
0140-673639.
Håkansson
K
, Rovio
S
, Helkala
EL
, Vilska
AR
, Winblad
B
, Soininen
H
, et al. Association between mid-life marital status and cognitive function in later life: population based cohort study
. BMJ
. 2009
Jul
;339
jul02 2
:b2462
.
[PubMed]
0959-813840.
van Gelder
BM
, Tijhuis
M
, Kalmijn
S
, Giampaoli
S
, Nissinen
A
, Kromhout
D
. Marital status and living situation during a 5-year period are associated with a subsequent 10-year cognitive decline in older men: the FINE Study
. J Gerontol B Psychol Sci Soc Sci
. 2006
Jul
;61
(4
):213
–9
.
[PubMed]
1079-501441.
Fratiglioni
L
, Paillard-Borg
S
, Winblad
B
. An active and socially integrated lifestyle in late life might protect against dementia
. Lancet Neurol
. 2004
Jun
;3
(6
):343
–53
.
[PubMed]
1474-442242.
Hanninen
T
, Koivisto
K
, Reinikainen
KJ
, Helkala
EL
, Soininen
H
, Mykkänen
L
, et al. Prevalence of ageing-associated cognitive decline in an elderly population
. Age Ageing
. 1996
May
;25
(3
):201
–5
.
[PubMed]
0002-072943.
Schröder
J
, Kratz
B
, Pantel
J
, Minnemann
E
, Lehr
U
, Sauer
H
. Prevalence of mild cognitive impairment in an elderly community sample
. J Neural Transm Suppl
. 1998
;54
:51
–9
.
[PubMed]
0303-699544.
Parisi
JM
. Engagement in Adulthood: Perceptions and Participation in Daily Activities
. Act Adaptation Aging
. 2010
;34
(1
):1
–16
.
[PubMed]
0192-478845.
Parisi
JM
, Rebok
GW
, Xue
QL
, Fried
LP
, Seeman
TE
, Tanner
EK
, et al. The role of education and intellectual activity on cognition
. J Aging Res
. 2012
;2012
:416132
.
[PubMed]
2090-220446.
Lenehan
ME
, Summers
MJ
, Saunders
NL
, Summers
JJ
, Vickers
JC
. Relationship between education and age-related cognitive decline: a review of recent research
. Psychogeriatrics
. 2014
.
[PubMed]
1346-350047.
Park
DC
, Reuter-Lorenz
P
. The adaptive brain: aging and neurocognitive scaffolding
. Annu Rev Psychol
. 2009
;60
(1
):173
–96
.
[PubMed]
0066-430848.
Scarmeas
N
, Stern
Y
. Cognitive reserve: implications for diagnosis and prevention of Alzheimer’s disease
. Curr Neurol Neurosci Rep
. 2004
Sep
;4
(5
):374
–80
.
[PubMed]
1528-404249.
Haan
MN
, Shemanski
L
, Jagust
WJ
, Manolio
TA
, Kuller
L
. The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons
. JAMA
. 1999
Jul
;282
(1
):40
–6
.
[PubMed]
0098-748450.
Reitz
C
, Luchsinger
JA
. Relation of Blood Pressure to Cognitive Impairment and Dementia
. Curr Hypertens Rev
. 2007
Aug
;3
(3
):166
–76
.
[PubMed]
1875-650651.
Waldstein
SR
, Giggey
PP
, Thayer
JF
, Zonderman
AB
. Nonlinear relations of blood pressure to cognitive function: the Baltimore Longitudinal Study of Aging
. Hypertension
. 2005
Mar
;45
(3
):374
–9
.
[PubMed]
0194-911X52.
Hebert
LE
, Scherr
PA
, Bennett
DA
, Bienias
JL
, Wilson
RS
, Morris
MC
, et al. Blood pressure and late-life cognitive function change: a biracial longitudinal population study
. Neurology
. 2004
Jun
;62
(11
):2021
–4
.
[PubMed]
0028-387853.
Reitz
C
, Tang
MX
, Manly
J
, Mayeux
R
, Luchsinger
JA
. Hypertension and the risk of mild cognitive impairment
. Arch Neurol
. 2007
Dec
;64
(12
):1734
–40
.
[PubMed]
0003-994254.
Solfrizzi
V
, Panza
F
, Colacicco
AM
, D’Introno
A
, Capurso
C
, Torres
F
, et al.; Italian Longitudinal Study on Aging Working Group
. Vascular risk factors, incidence of MCI, and rates of progression to dementia
. Neurology
. 2004
Nov
;63
(10
):1882
–91
.
[PubMed]
0028-387855.
Pavlik
VN
, de Moraes
SA
, Szklo
M
, Knopman
DS
, Mosley
TH
Jr, Hyman
DJ
. Relation between cognitive function and mortality in middle-aged adults: the atherosclerosis risk in communities study
. Am J Epidemiol
. 2003
Feb
;157
(4
):327
–34
.
[PubMed]
0002-926256.
Suhr
JA
, Stewart
JC
, France
CR
. The relationship between blood pressure and cognitive performance in the Third National Health and Nutrition Examination Survey (NHANES III)
. Psychosom Med
. 2004
May-Jun
;66
(3
):291
–7
.
[PubMed]
1534-7796© 2019 S. Karger AG, Basel
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