Background: The Relational and Item-Specific Encoding task (RISE) measures episodic memory subcomponents, including item-specific and relational encoding of to-be-remembered stimuli. These memory components are neurobiologically relevant because they may engage distinct subregions of the medial temporal lobe, perirhinal and entorhinal cortices, parahippocampus, and hippocampus. Methods: A total of 125 participants, including 84 healthy controls (HC), 22 mild cognitive impairment-diagnosed and 19 Alzheimer disease (AD)-diagnosed participants, were administered the RISE and neuropsychological measures. Stepwise linear regressions assessed prediction of functional ability from RISE d′ measures. ANOVAs and logistic regressions determined the ability of the RISE to discriminate between the diagnostic groups. In addition, the psychometric properties of the RISE were examined. Results: RISE measures predicted diagnosis with pseudo R2 values in the range of 0.25-0.30. Receiver operating characteristic curves demonstrated adequate sensitivity and specificity with areas under the curve in the range of 0.78-0.98. Memory following relational encoding was a significant predictor of everyday functional competence. The RISE had acceptable psychometric properties, with the exception of floor effects in the AD group. Conclusion: The RISE measures significantly predicted diagnosis and predicted everyday functional competence. The RISE offers unique advantages in the assessment of HC and individuals with preclinical AD.

Tulving E, Markowitsch HJ: Episodic and declarative memory: role of the hippocampus. Hippocampus 1998;8:198-204.
Eichenbaum H, Otto T, Cohen NJ: The hippocampus - what does it do? Behav Neural Biol 1992;57:2-36.
Davachi L, Wagner AD: Hippocampal contributions to episodic encoding: insights from relational and item-based learning. J Neurophysiol 2002;88:982-990.
Ranganath C, Ritchey M: Two cortical systems for memory-guided behaviour. Nat Rev Neurosci 2012;13:713-726.
Ragland JD, Ranganath C, Barch DM, Gold JM, Haley B, MacDonald AW 3rd, Silverstein SM, Strauss ME, Yonelinas AP, Carter CS: Relational and Item-Specific Encoding (RISE): task development and psychometric characteristics. Schizophr Bull 2012;38:114-124.
Ragland JD, Ranganath C, Harms MP, Barch DM, Gold JM, Layher E, Lesh TA, MacDonald AW 3rd, Niendam TA, Phillips J, Silverstein SM, Yonelinas AP, Carter CS: Functional and neuroanatomic specificity of episodic memory dysfunction in schizophrenia: a functional magnetic resonance imaging study of the Relational and Item-Specific Encoding task. JAMA Psychiatry 2015;72:909-916.
Killiany RJ, Hyman BT, Gomez-Isla T, Moss MB, Kikinis R, Jolesz F, Tanzi R, Jones K, Albert MS: MRI measures of entorhinal cortex vs hippocampus in preclinical AD. Neurology 2002;58:1188-1196.
Sheffield JM, Gold JM, Strauss ME, Carter CS, MacDonald AW 3rd, Ragland JD, Silverstein SM, Barch DM: Common and specific cognitive deficits in schizophrenia: relationships to function. Cogn Affect Behav Neurosci 2014;14:161-174.
Goldberg TE, Koppel J, Keehlisen L, Christen E, Dreses-Werringloer U, Conejero-Goldberg C, Gordon ML, Davies P: Performance-based measures of everyday function in mild cognitive impairment. Am J Psychiatry 2010;167:845-853.
Gomar JJ, Harvey PD, Bobes-Bascaran MT, Davies P, Goldberg TE: Development and cross-validation of the UPSA short form for the performance-based functional assessment of patients with mild cognitive impairment and Alzheimer disease. Am J Geriatr Psychiatry 2011;19:915-922.
Flowers KA, Bolton C, Brindle N: Chance guessing in a forced-choice recognition task and the detection of malingering. Neuropsychology 2008;22:273-277.
Pennanen C, Kivipelto M, Tuomainen S, Hartikainen P, Hänninen T, Laakso MP, Hallikainen M, Vanhanen M, Nissinen A, Helkala EL, Vainio P, Vanninen R, Partanen K, Soininen H: Hippocampus and entorhinal cortex in mild cognitive impairment and early AD. Neurobiol Aging 2004;25:303-310.
Davachi L, Mitchell JP, Wagner AD: Multiple routes to memory: distinct medial temporal lobe processes build item and source memories. Proc Natl Acad Sci USA 2003;100:2157-2162.
Davachi L: Item, context and relational episodic encoding in humans. Curr Opin Neurobiol 2006;16:693-700.
Herlitz A, Airaksinen E, Nordström E: Sex differences in episodic memory: the impact of verbal and visuospatial ability. Neuropsychology 1999;13:590-597.
Lundervold AJ, Wollschläger D, Wehling E: Age and sex related changes in episodic memory function in middle aged and older adults. Scand J Psychol 2014;55:225-232.
Vakil E, Hornik C, Levy DA: Conceptual and perceptual similarity between encoding and retrieval contexts and recognition memory context effects in older and younger adults. J Gerontol B Psychol Sci Soc Sci 2008;63:P171-P175.
Green MF: What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 1996;153:321-330.
Tucker-Drob EM: Neurocognitive functions and everyday functions change together in old age. Neuropsychology 2011;25:368-377.
Devanand DP, Bansal R, Liu J, Hao X, Pradhaban G, Peterson BS: MRI hippocampal and entorhinal cortex mapping in predicting conversion to Alzheimer's disease. Neuroimage 2012;60:1622-1629.
Saykin AJ, Shen L, Foroud TM, Potkin SG, Swaminathan S, Kim S, Risacher SL, Nho K, Huentelman MJ, Craig DW, Thompson PM, Stein JL, Moore JH, Farrer LA, Green RC, Bertram L, Jack CR Jr, Weiner MW: Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: genetics core aims, progress, and plans. Alzheimers Dement 2010;6:265-273.
Mueller SG, Schuff N, Yaffe K, Madison C, Miller B, Weiner MW: Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease. Hum Brain Mapp 2010;31:1339-1347.
Sousa A, Gomar JJ, Goldberg TE: Neural and behavioral substrates of disorientation in mild cognitive impairment and Alzheimer's disease. Alzheimers Dement 2015;1:37-45.
Gomar JJ, Conejero-Goldberg C, Davies P, Goldberg TE; Alzheimer's Disease Neuroimaging Initiative: Extension and refinement of the predictive value of different classes of markers in ADNI: four-year follow-up data. Alzheimers Dement 2014;10:704-712.
Schuff N, Woerner N, Boreta L, Kornfield T, Shaw LM, Trojanowski JQ, Thompson PM, Jack CR Jr, Weiner MW; Alzheimer's Disease Neuroimaging Initiative: MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain 2009;132(pt 4):1067-1077.
Reiman EM, Uecker A, Caselli RJ, Lewis S, Bandy D, de Leon MJ, De Santi S, Convit A, Osborne D, Weaver A, Thibodeau SN: Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease. Ann Neurol 1998;44:288-291.
Wixted JT, Squire LR: The medial temporal lobe and the attributes of memory. Trends Cogn Sci 2011;15:210-217.
Stark CE, Bayley PJ, Squire LR: Recognition memory for single items and for associations is similarly impaired following damage to the hippocampal region. Learn Mem 2002;9:238-242.
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