Background: Several studies have stated that frailty is associated with cognitive impairment. Based on various studies, cognition impairment has been considered as a component of frailty. Other authors have shown that physical frailty is associated with low cognitive performance. Dual task gait tests are used as a strong predictor of falls in either dementia or frailty. Consequently, it is important to investigate dual task walking tests in elderly populations including control robust oldest old, frail oldest old with mild cognitive impairment (MCI) and frail oldest old without MCI. Methods: Dual task walking tests were carried out to examine the association between frailty and cognitive impairment in a population with advanced age. Forty-one elderly men and women participated in this study. The subjects from control, frail with MCI and frail without MCI groups, completed the 5-meter walk test at their own gait velocity. Arithmetic and verbal dual task walking performance was also assessed. Kinematic data were acquired from a unique tri-axial inertial sensor. Results: The spatiotemporal and frequency parameters related to gait disorders did not show any significant differences between frail with and without MCI groups. Conclusions: The evaluation of these parameters extracted from the acceleration signals led us to conclude that these results expand the knowledge regarding the common conditions in frailty and MCI and may highlight the idea that the impairment in walking performance does not depend of frailty and cognitive status.

1.
Morley JE: Diabetes, sarcopenia, and frailty. Clin Geriatr Med 2008;24:455-469.
2.
Janssen I, Heymsfield SB, Ross R: Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 2002;50:889-896.
3.
Hogan DB, MacKnight C, Bergman H; Steering Committee, Canadian Initiative on Frailty and Aging: Models, definitions, and criteria of frailty. Aging Clin Exp Res 2003;15:1-29.
4.
Visser M, Deeg DJ, Lips P: Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab 2003;88:5766-5772.
5.
Suzuki T, Shimada H, Makizako H, Doi T, Yoshida D, Ito K, Shimokata H, Washimi Y, Endo H, Kato T: A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment. PLoS One 2013;8:e61483.
6.
Juarez-Cedillo T, Sanchez-Arenas R, Sanchez-Garcia S, Garcia-Pena C, Hsiung GY, Sepehry AA, Beattie BL, Jacova C: Prevalence of mild cognitive impairment and its subtypes in the Mexican population. Dement Geriatr Cogn Disord 2012;34:271-281.
7.
Ávila‐Funes JA, Amieva H, Barberger‐Gateau P, Le Goff M, Raoux N, Ritchie K, Carriere I, Tavernier B, Tzourio C, Gutiérrez‐Robledo LM: Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the three-city study. J Am Geriatr Soc 2009;57:453-461.
8.
Casas-Herrero A, Cadore EL, Zambom-Ferraresi F, Idoate F, Millor N, Martinez-Ramirez A, Gomez M, Rodriguez-Manas L, Marcellan T, de Gordoa AR, Marques MC, Izquierdo M: Functional capacity, muscle fat infiltration, power output, and cognitive impairment in institutionalized frail oldest old. Rejuvenation Res 2013;16:396-403.
9.
Pitkala KH, Laurila JV, Strandberg TE, Tilvis RS: Prognostic significance of delirium in frail older people. Dement Geriatr Cogn Disord 2005;19:158-163.
10.
Samper-Ternent R, Al Snih S, Raji MA, Markides KS, Ottenbacher KJ: Relationship between frailty and cognitive decline in older Mexican Americans. J Am Geriatr Soc 2008;56:1845-1852.
11.
Buchman AS, Boyle PA, Wilson RS, Tang Y, Bennett DA: Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly. Psychosom Med 2007;69:483-489.
12.
Alfaro-Acha A, Al Snih S, Raji MA, Markides KS, Ottenbacher KJ: Does 8-foot walk time predict cognitive decline in older Mexicans Americans? J Am Geriatr Soc 2007;55:245-251.
13.
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group: Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56:M146-M157.
14.
Garcia-Garcia FJ, Gutierrez Avila G, Alfaro-Acha A, Amor Andres MS, et al: The prevalence of frailty syndrome in an older population from Spain. The Toledo Study for Healthy Aging. J Nutr Health Aging 2011;15:852-856.
15.
Doi T, Makizako H, Shimada H, Yoshida D, Ito K, Kato T, Ando H, Suzuki T: Brain atrophy and trunk stability during dual-task walking among older adults. J Gerontol A Biol Sci Med Sci 2012;67:790-795.
16.
Herman T, Mirelman A, Giladi N, Schweiger A, Hausdorff JM: Executive control deficits as a prodrome to falls in healthy older adults: a prospective study linking thinking, walking, and falling. J Gerontol A Biol Sci Med Sci 2010;65:1086-1092.
17.
Lee KS, Kim EA, Hong CH, Lee DW, Oh BH, Cheong HK: Clock drawing test in mild cognitive impairment: quantitative analysis of four scoring methods and qualitative analysis. Dement Geriatr Cogn Disord 2008;26:483-489.
18.
Allali G, Dubois B, Assal F, Lallart E, de Souza LC, Bertoux M, Annweiler C, Herrmann FR, Levy R, Beauchet O: Frontotemporal dementia: pathology of gait? Mov Disord 2010;25:723.
19.
Montero-Odasso M, Muir SW, Speechley M: Dual-task complexity affects gait in people with mild cognitive impairment: the interplay between gait variability, dual tasking, and risk of falls. Arch Phys Med Rehabil 2012;93:293-299.
20.
Pettersson AF, Olsson E, Wahlund LO: Motor function in subjects with mild cognitive impairment and early Alzheimer's disease. Dement Geriatr Cogn Disord 2005;19:299-304.
21.
Millor N, Lecumberri P, Gomez M, Martinez-Ramirez A, Izquierdo M: An evaluation of the 30-s chair stand test in older adults: frailty detection based on kinematic parameters from a single inertial unit. J Neuroeng Rehabil 2013;10:86.
22.
Martínez-Ramírez A, Lecumberri P, Gómez M, Rodriguez-Mañas L, García F, Izquierdo M: Frailty assessment based on wavelet analysis during quiet standing balance test. J Biomech 2011;44:2213-2220.
23.
Winblad B, Palmer K, Kivipelto M, Jelic V, et al: Mild cognitive impairment - beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 2004;256:240-246.
24.
Taylor HL, Jacobs DR, Schucker B, Knudsen J, Leon AS, Debacker G: A questionnaire for the assessment of leisure time physical activities. J Chronic Dis 1978;31:741-755.
25.
Orme JG, Reis J, Herz EJ: Factorial and discriminant validity of the Center for Epidemiological Studies Depression (CES‐D) Scale. J Clin Psychol 1986;42:28-33.
26.
Morris JC: The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 1993;43:2412-2414.
27.
Hantikainen V: Physical restraint: a descriptive study in Swiss nursing homes. Nurs Ethics 1998;5:330-346.
28.
Hamers FJ: Why do we use physical restraints in the elderly? Z Gerontol Geriatr 2005;38:19-25.
29.
Gulpers MJ, Bleijlevens MH, van Rossum E, Capezuti E, Hamers JP: Belt restraint reduction in nursing homes: design of a quasi-experimental study. BMC Geriatr 2010;10:11.
30.
Moe-Nilssen R, Helbostad JL: Estimation of gait cycle characteristics by trunk accelerometry. J Biomech 2004;37:121-126.
31.
Yang CC, Hsu YL, Shih KS, Lu JM: Real-time gait cycle parameter recognition using a wearable accelerometry system. Sensors (Basel) 2011;11:7314-7326.
32.
Karmakar CK, Khandoker AH, Begg RK, Palaniswami M, Taylor S: Understanding ageing effects by approximate entropy analysis of gait variability. Conf Proc IEEE Eng Med Biol Soc 2007;2007:1965-1968.
33.
Montero-Odasso M, Muir SW, Hall M, Doherty TJ, Kloseck M, Beauchet O, Speechley M: Gait variability is associated with frailty in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 2011;66A:568-576.
34.
Brach JS, McGurl D, Wert D, VanSwearingen JM, Perera S, Cham R, Studenski S: Validation of a measure of smoothness of walking. J Gerontol A Biol Sci Med Sci 2011;66A:136-141.
35.
Menz HB, Lord SR, Fitzpatrick RC: Age-related differences in walking stability. Age Ageing 2003;32:137-142.
36.
Martinikorena I, Martínez-Ramírez A, Gómez M, Lecumberri P, Casas-Herrero A, Cadore EL, Millor N, Zambom-Ferraresi F, Idoate F, Izquierdo M: Gait variability related to muscle quality and muscle power output in frail nonagenarian older adults. J Am Med Dir Assoc 2016;17:162-167.
37.
Martínez-Ramírez A, Martinikorena I, Gómez M, Lecumberri P, Millor N, Rodríguez-Mañas L, García FJG, Izquierdo M: Frailty assessment based on trunk kinematic parameters during walking. J Neuroeng Rehabil 2015;12:1.
38.
Pincus S, Gladstone I, Ehrenkranz R: A regularity statistic for medical data analysis. J Clin Monit 1991;7:335-345.
39.
Ho KKL, Moody GB, Peng C, Mietus JE, Larson MG, Levy D, Goldberger AL: Predicting survival in heart failure case and control subjects by use of fully automated methods for deriving nonlinear and conventional indices of heart rate dynamics. Circulation 1997;96:842-848.
40.
Martínez-Ramírez A, Martinikorena I, Gómez M, Lecumberri P, Millor N, Rodríguez-Mañas L, García FJG, Izquierdo M: Frailty assessment based on trunk kinematic parameters during walking. J Neuroeng Rehabil 2015;12:48.
41.
Galan-Mercant A, Cuesta-Vargas A: Differences in trunk accelerometry between frail and non-frail elderly persons in functional tasks. BMC Res Notes 2014;7:100.
42.
Montero-Odasso M, Oteng-Amoako A, Speechley M, Gopaul K, Beauchet O, Annweiler C, Muir-Hunter SW: The motor signature of mild cognitive impairment: results from the Gait and Brain Study. J Gerontol A Biol Sci Med Sci 2014;69:1415-1421.
43.
Cano C, Samper-Ternent R, Al Snih S, Markides K, Ottenbacher KJ: Frailty and cognitive impairment as predictors of mortality in older Mexican Americans. J Nutr Health Aging 2012;16:142-147.
44.
Marquis S, Moore M, Howieson DB, et al: Independent predictors of cognitive decline in healthy elderly persons. Arch Neurol 2002;59:601-606.
45.
Uemura K, Doi T, Shimada H, Makizako H, Yoshida D, Tsutsumimoto K, Anan Y, Suzuki T: Effects of exercise intervention on vascular risk factors in older adults with mild cognitive impairment: a randomized controlled trial. Dement Geriatr Cogn Disord Extra 2012;2:445-455.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.