Objective: Examination of the utility of 99mTc-hexamethylpropylene amine oxide (99mTc-HM-PAO) SPECT hippocampal image to diagnose early stages of Alzheimer’s disease (AD) using semiquantitative analysis. Subjects: 10 early-stage AD patients and 8 normal sex-matched elderly controls. Setting: Outpatient division of the Ehime University Hospital. Method: We performed 99mTc-HM-PAO SPECT perfusion imaging in each subject. A semiquantitative method of assessing regional variation was used. The regions of interest for temporal regions were set at images parallel to the long axis of the hippocampal formation which were reconstructed at 30Results: The regional cerebral blood flow ratio of the bilateral medial temporal lobe at the hippocampal image was significantly lower in the AD subjects than in the normally aged controls without any other differences in ordinary transaxial images. Conclusion: This study suggests that 99mTc-HM-PAO SPECT hippocampal images might be a helpful tool for the diagnosis of very-early-stage AD.

Keywords:
99mTc-HM-PAO SPECT hippocampal image, Alzheimer’s disease, early stages, Diagnosis, early, Semiquantitative analysis
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© 2001 S. Karger AG, Basel
2001
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