...Hiroyuki Sato; Miho Ota; Ayako Kitabatake; Yuriko Numata; Takumi Takahashi; Masashi Tamura; Kiyotaka Nemoto; Tetsuaki Arai Introduction: Although the prevalence of Alzheimer’s disease (AD) is higher in older people compared to younger people, dementia has also been documented in younger adults...

...Cecilia Magdalena Eriksson; Bjørn-Eivind Kirsebom; Ragna Espenes; Nikias Siafarikas; Knut Waterloo; Arvid Rongve; Per Selnes; Dag Aarsland; Tormod Fladby; Erik Hessen Introduction: Depressive symptoms are associated with Alzheimer’s disease (AD), but their neurobiological and neuropsychological...

...Suzan van Amerongen; Dewi K. Caton; Yolande A.L. Pijnenburg; Philip Scheltens; Everard G.B. Vijverberg Introduction: Traumatic brain injury (TBI) has been associated with a greater risk of developing Alzheimer’s disease (AD). Less is known about the clinical features of AD patients with TBI history...

... in situations of insufficient glucose supply. Alzheimer’s disease (AD) and Parkinson’s disease are the most common neurodegenerative diseases in the world. It is believed that carbohydrate metabolism disorders may affect the progression of these diseases, as confirmed by both animal and human studies. Among...

..., the effect of time to detection on the measured concentrations of proteins in human plasma after mixing the reagent and sample is examined. Methods: The proteins analyzed are related to Alzheimer’s disease: amyloid β 1–40, amyloid β 1–42, and Tau protein. The investigated times to detection after the mixing...

...Dixon Yang; Arjun Masurkar Introduction: Alzheimer’s disease (AD) and cerebral small vessel disease (CVSD) both contribute to age-related cognitive decline but can be difficult to clinically distinguish at early stages. At mild cognitive impairment (MCI), we investigated brain MRI volumetric...

... Neurodegenerative disease Alzheimer’s disease Marital satisfaction Disease severity Caregiver burden More than 15 million people provide informal care for persons living with dementia (PLWDs) in the USA, which involves immense emotional, physical, and practical support [1-4]. Growing evidence suggests...

... members and caregivers. Donepezil is used to treat Alzheimer’s disease and is metabolized via cytochrome P450 (CYP) 2D6 and CYP3A4/5. It is controversial whether donepezil improves or exacerbates BPSD. This study investigated the relationships among BPSD, the pharmacokinetics of donepezil including its...

...Jaime D. Mondragón; Ramesh Marapin; Peter Paul De Deyn; Natasha Maurits; for the Alzheimer’s Disease Neuroimaging Initiative Introduction: Progression of amnestic mild cognitive impairment (aMCI) to Alzheimer’s disease (AD) is a clinical event with highly variable progression rates varying from 10...

...Jong-hoon Lee; Chul Joong Lee; Jungwuk Park; So Jeong Lee; Su-hee Choi Aim/Background: This review investigated a patient with Alzheimer’s disease (AD) treated with 4,4’-diaminodiphenyl sulfone (DDS) as a neuroinflammasome competitor. Methods: We monitored AD’s progression through numeric clinical...

...Natalia Szejko; Pedro Macul Ferreira de Barros; Victor J. Avila-Quintero; Adam Lombroso; Michael Howard Bloch Background: Alzheimer’s disease (AD) is the most common cause of dementia worldwide, accounting for 50–75% of all cases. While older maternal and paternal age at childbirth are established...

...Yumi Watanabe; Yoshitoshi Hirao; Kensaku Kasuga; Takayoshi Tokutake; Kaori Kitamura; Shumpei Niida; Takeshi Ikeuchi; Kazutoshi Nakamura; Tadashi Yamamoto Introduction: Biomarkers of Alzheimer’s disease (AD) that can easily be measured in routine health checkups are desirable. Urine is a source...

...Niki Udo; Naoki Hashimoto; Takuya Toyonaga; Tomoyuki Isoyama; Yuka Oyanagi; Hisashi Narita; Tohru Shiga; Shin Nakagawa; Ichiro Kusumi Introduction: Apathy is a common neuropsychiatric symptom in patients with Alzheimer’s disease (AD). The striatal binding potential (BP) of 123 I-FP-CIT ( N -δ...

...Yuka Oishi; Toru Imamura; Tatsuo Shimomura; Kyoko Suzuki Introduction: Although various visual function deficits have been reported in patients with Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB), vegetable freshness perception has not been thoroughly examined. Objective...

... implicated in Alzheimer’s disease (AD). Several studies suggested onset age-dependent decreases in cerebral blood flow in these regions in AD, but these studies did not screen for amyloid accumulation, suggesting inclusion of non-AD patients in their subjects. Objective: By applying eZIS-SPECT to patients...

...Yasuhiro Nagahama; Toshiya Fukui; Hiroshi Akutagawa; Hiroko Ohtaki; Momoka Okabe; Tatsuya Ito; Hiroko Suga; Hiroshige Fujishiro Objective: To explore the prevalence and clinical implications of the mirror and TV signs in the moderate to advanced stages of Alzheimer’s disease (AD) and dementia...

...Huei-Chun Liu; Ming-Jang Chiu; Chin-Hsien Lin; Shieh-Yueh Yang Introduction: Blood biomarkers of Alzheimer’s disease (AD) have attracted much attention of researchers in recent years. In clinical studies, repeated freeze/thaw cycles often occur and may influence the stability of biomarkers...

...Jong-hoon Lee; Su-hee Choi; Chul Joong Lee; Sang-suk Oh Aim/Background: This research aims to prevent progression from mild cognitive impairment (MCI) to Alzheimer’s disease. A Japanese study of leprosy patients revealed that the incidence of dementia in leprosy patients was lower than...

... of qualitative errors obtained through the qualitative analysis of CDT may be related to the participant’s falls. The aim of this study was to clarify the difference in the number of people who presented with qualitative errors in the CDT between a fall and non-fall group of patients with Alzheimer’s disease (AD...

... Nakamura Background: Few studies have investigated treatment options for patients with Alzheimer’s disease (AD) showing a poor response to oral cholinesterase inhibitors (ChEIs) in Japan. Objective: To investigate the efficacy and safety of switching from oral ChEIs to rivastigmine transdermal patch...