...Marla C. Dubinsky; Alessandro Armuzzi; Krisztina B. Gecse; Thomas Ullman; Andrew G. Bushmakin; Marco DiBonaventura; Joseph C. Cappelleri; Susan B. Connelly; John C. Woolcott; Leonardo Salese Background: Patients with ulcerative colitis (UC) often report impaired health-related quality of life...

... interventions, such as fecal microbiota transplantation (FMT), have attracted interest in the management of IBD, including ulcerative colitis (UC). Summary: While the clinical response to FMT in UC has varied between different studies, results to date may offer guidance toward optimal use of FMT. Thus...

... colonoscopy (AIC) in terms of the cecal intubation rate. However, the application of WAC in ulcerative colitis (UC) has rarely been reported. This study aimed to explore the effectiveness of WAC without sedation in patients with UC. Methods: One hundred and seventy-two UC patients were randomly divided...

... medical records. Other disease information was collected from a self-designed general questionnaire. The disease activity of CD was assessed by the Harvey-Bradshaw Index (HBI) and Walmsley Simple Clinical Colitis Activity Index (SCCAI) for ulcerative colitis. Nutrition was assessed by Nutrition Risk...

... of clinical remission in patients with moderate to severe ulcerative colitis (UC) is achieved after biological therapy only in 16–39%. Individualization of therapeutic intervention would benefit from prediction of early response. Study Objective: The primary objective of our study was to assess golimumab (GLM...

... of our study was to investigate antibody response to SARS-CoV-2 vaccination in patients with IBD receiving immunomodulators or biologics compared to healthy controls. Methods: This was a single-center study with a retrospective observational design. Seventy-two patients with ulcerative colitis or Crohn’s...

... and dissociative symptoms in a sample of IBD patients compared to healthy controls. A possible relationship with disease activity was also investigated. Methods: A total of 112 IBD patients, 55 Crohn’s disease (CD) and 57 ulcerative colitis (UC), and 114 healthy individuals were evaluated. IBD patients were...

...Millie D. Long; Russell D. Cohen; Timothy W. Smith; Marco DiBonaventura; David Gruben; Danielle Bargo; Leonardo Salese; Daniel Quirk Background: Biologic therapies are often used in patients with ulcerative colitis (UC) who are nonresponsive to conventional treatments. However, nonresponse or loss...

...Wolfgang Stremmel; Hüseyin Vural; Osman Evliyaoglu; Ralf Weiskirchen Background: Phosphatidylcholine (PC) is intrinsically missing in intestinal mucus of patients with ulcerative colitis. Topical supplementation with delayed intestinal release PC formulations is assumed to compensate this lack...

...Ting Yu; Fanyu Meng; Minning Xie; Huajiang Liu; Lei Zhang; Xinghua Chen Background: Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic inflammation of the colon. It has been reported that PMS2L2 plays protective roles in inflammatory injury. This study aimed...

...) drugs in inflammatory bowel disease patients are lacking. Aim: To compare the effectiveness and tolerability of anti-TNF-α drugs used in clinical practice in a cohort of patients with moderate-to-severe ulcerative colitis (UC). Methods: Retrospectively, 122 UC patients treated with infliximab (IFX...

... and their role in sleep quality are unknown. In this study, we aimed to examine whether and how patients with ulcerative colitis (UC) and Crohn’s disease (CD) differ on sleep quality, sleepiness level, and dream anxiety (DA) level compared to healthy controls (HC), controlling for their depressive and anxious...

... considering endoscopic remission (7.5 to >13.9 µg/mL). Although the sample of patients with ulcerative colitis is small, a tendency to reach higher levels of ADA is observed in both clinical and endoscopic remission. Key Messages: The optimal therapeutic cut-off point of serum ADA levels ranges from 4.5–5...

... in the study. 42Forty-two (63%) of the CD and 13 (59%) of the ulcerative colitis patients met the criteria for osteoporosis/osteopenia. Factors associated with lower Z scores were low body mass index (BMI; r = –0.307, p = 0.005), use of glucocorticoids (likelihood ratio [LR] 5.1, p = 0.028), and a trend...

... literature review and consensus meeting to identify unmet needs in ulcerative colitis (UC) and ways to overcome them. UC is a relapsing and remitting inflammatory bowel disease with varied, and changing, incidence rates worldwide. UC has an unpredictable disease course and is associated with a high health...

...Jeanne H.M. de Vries; Milou Dijkhuizen; Petra Tap; Ben J.M. Witteman Background: The inflammatory bowel disease (IBD) is a chronic lifelong inflammation that may affect the entire gastro-intestinal tract in Crohn’s disease and the colon in ulcerative colitis (UC). Diet plays an important role...

...Stefania Chetcuti Zammit; John Schembri; Anthea Pisani; Sarah Vella; Matthias Azzopardi; Alexandros Skamnelos; Dimitrios K. Christodoulou; Konstantinos H. Katsanos; Pierre Ellul Introduction: Patients with ulcerative colitis (UC) can suffer from low serum vitamin D that can result in complications...

... ileostomy closure, 63 patients (76%) had 4–6 day-time and 47 patients (57%) had no night-time bowel movements. A stapled IPAA resulted in better St Mark’s ( p = 0.0064) and Wexner scores ( p = 0.0019) than did a hand-sewn anastomosis. The younger the patients were at the onset of ulcerative colitis (UC...

...Ken Sugimoto; Kentaro Ikeya; Masaichi Kato; Ai Matsuura; Fumitoshi Watanabe; Ryosuke Takano; Satoshi Tamura; Shinya Tani; Satoshi Osawa; Hiroyuki Hanai Background: Although evidence for the short- to medium-term efficacy of adalimumab in ulcerative colitis (UC) patients is emerging...

...Nasser Ebrahimi Daryani; Maryam Sadr; Samaneh Soltani; Amene Saghazadeh; Shirin Moossavi; Sepideh Shahkarami; Elham Farhadi; Nima Rezaei Background: Inflammatory bowel disease (IBD) mostly comprised of Crohn’s disease (CD) and ulcerative colitis (UC) is a condition arising from the combined effects...