... obtained by combining TE and CAP in the non-invasive assessment of liver fibrosis and steatosis [ 8 ]. Interestingly, MRI permits the use of intrinsic internal body motions rather than externally induced vibration waves in elastography. Cardiac-induced [ 9 ] or respiratory-induced [ 10 ] motion...

... the issue of whether patients with risk factors for NAFLD (diabetes and/or metabolic syndrome [MS]) should be screened for its presence with biomarkers, such as the fatty liver index (FLI). The diagnosis of NAFLD requires the exclusion of other causes of chronic liver disease and steatosis, especially heavy...

...Sandra Bühler; Ralf Bartenschlager Persistent infection with the hepatitis C virus (HCV) is a major global health problem. Around 2–3% of the world’s population are chronically infected, and infected individuals are at high risk of developing steatosis, fibrosis, and liver cirrhosis. The latter...

...Christopher Paul Day Non-alcoholic fatty liver disease is increasingly being diagnosed worldwide and considered to be the commonest liver disorder in Western countries. It comprises a disease spectrum ranging from simple steatosis (fatty liver) through non-alcoholic steatohepatitis (NASH) to fat...

...Flemming Bendtsen; Sanne Dam-Larsen The risk of progression to cirrhosis and death in patients with pure alcoholic (AFLD) and non-alcoholic steatosis (NAFLD) has only sparsely been studied. The aims of the present long-term follow-up study were to analyze for risks of progression to cirrhosis...

... counterpoint to the argument that the enteral feeding model is not relevant to human alcohol exposure. Pathological changes in the liver of human abusers of alcohol range from mild (steatosis) to moderate (steatohepatitis and early fibrosis) to advanced (late fibrosis and cirrhosis) dependent upon both...

..., particularly in the context of non-alcoholic fatty liver disease (NAFLD), support a critical role for PTEN in hepatic insulin sensitivity and the development of steatosis, steatohepatitis and fibrosis. PTEN mutations/deletion or low PTEN expression are also associated with diverse liver malignancies...

...Beate Katharina Straub; Peter Schirmacher Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent liver diseases in Western industrialized countries with dramatically rising incidence. The diagnosis of NAFLD requires the existence of steatosis in the absence of significant alcohol...

...-limited and are 10 times more likely to occur with total parenteral nutrition (TPN) than tube enteral nutrition. Patients on short-term TPN usually have mild-to-moderate elevations in transaminase and alkaline phosphatase levels and steatosis or portal triaditis on biopsy. Patients who are infected while...

... of alcoholic liver disease, especially on steatosis, alcoholic hepatitis and fibrosis. Methods: The various forms of alcoholic liver disease are described, and knowledge about the clinical and pathophysiological features of different stages of alcoholic liver disease are summarized. Results: Clinical studies...