...Xia Peng; Xin Luo; Jing-Ying Hou; Shu-Yun Wu; Liang-Zong Li; Ming-Hua Zheng; Ling-Yun Wang Objectives: Currently, there are no effective therapeutic agents for patients with primary sclerosing cholangitis (PSC). This study aimed to evaluate the safety and efficiency of immunosuppressive agents (IAs...

... hepatitis Primary biliary cholangitis Primary sclerosing cholangitis Autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) are immune-mediated liver diseases featuring distinct HLA associations of unknown significance. AIH is marked...

... drug for a range of cholestatic liver and bile duct disorders. Recently, norUDCA has been successfully tested clinically in patients with primary sclerosing cholangitis (PSC) as first application in patients. Moreover, hepatic enrichment of norUDCA facilitates direct therapeutic effects on both...

... physiological role in the enterohepatic circulation of BAs and therefore essential for the BA homeostasis. Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), the 2 most common cholestatic liver diseases are characterised by altered BA flow and BA composition, which contribute to disease...

...Christina Weiler-Normann; Ansgar W. Lohse The term ‘overlap syndrome' has been used to describe the presence of both autoimmune hepatitis and primary biliary cholangitis or primary sclerosing cholangitis in the past. As this term is misleading, the term ‘variant syndrome' should be used preferably...

... (PBC) and primary sclerosing cholangitis (PSC) patients have been recently proposed. In addition, major insight has been gained into bile acid (BA) physiology during the last decade including the role of BAs as metabolic modulators and the gut-liver axis. As a consequence, alongside drugs targeting...

...Tom H. Karlsen; Brian K. Chung Primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) have collectively been recognized as autoimmune liver diseases. They have all been subjected to genome-wide association studies (GWAS) and several dozens...

...Olivier Chazouillères Background: Some patients present with features of both primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC) on the one hand and autoimmune hepatitis (AIH) on the other hand, either simultaneously or consecutively. The term ‘overlap syndrome (OS)' is used...

...Cyriel Y. Ponsioen According to recent guidelines, primary sclerosing cholangitis (PSC) is diagnosed when a patient has a cholestatic liver enzyme profile, characteristic bile duct changes on imaging, and when secondary causes of sclerosing cholangitis are excluded. In patients with a clinical...

... diseases such as primary sclerosing cholangitis (PSC) or cholangiocarcinoma. The HISORt criteria - histopathological, imaging, and serological features (sIgG4), other organ manifestations of IgG4-RD and response to treatment - are the standard for the diagnosis of IAC. In this overview of a recent lecture...

... biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and immunoglobulin G4-associated cholangitis (IAC) in general populations. Key Messages: We found relevant studies through Medline and Scopus, and we examined whether they were population-based; the way they found cases for inclusion and which...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Primary sclerosing cholangitis Primary biliary cirrhosis Bicarbonate umbrella Nonalcoholic fatty liver disease Atherosclerosis 24- nor- ursodeoxycholic acid ( nor UDCA...

... a model of disease for which environmental and genetic influences are highly relevant to why any individual develops disease. The overlapping clinical presentations of primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune hepatitis further highlight the likelihood for shared pathways...

...Michael Trauner; Emina Halilbasic; Lili Kazemi-Shirazi; Christian Kienbacher; Katharina Staufer; Stefan Traussnigg; Harald Hofer Chronic inflammatory bile duct diseases such as primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) result in progressive fibrosis of the biliary...

...Kate D. Williamson; Roger W. Chapman Primary sclerosing cholangitis (PSC) is a chronic, cholestatic liver disease caused by diffuse inflammation and fibrosis that can involve the entire biliary tree. It is a progressive disorder which can ultimately lead to biliary cirrhosis, portal hypertension...

...V. Wieser; R. Gerner; A.R. Moschen; H. Tilg Diseases of the liver and the biliary tract are commonly observed in patients with inflammatory bowel diseases (IBD). Besides primary sclerosing cholangitis (PSC), drug-induced hepatotoxicity and non-alcoholic fatty liver disease (NAFLD) are the most...

...- and extrahepatic bile ducts. Recent genome-wide association studies have confirmed major histocompatibility complex associations and discovered multiple susceptibility loci in primary biliary cirrhosis and primary sclerosing cholangitis, providing new insights into disease pathogenesis, which may translate...

...Hanno Ehlken; Christoph Schramm Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease caused by progressive inflammation of the intra- and extrahepatic bile duct system. PSC patients have an increased risk to develop hepatobiliary as well as extrahepatic malignancies. The goal...

...Tom H. Karlsen As a result of international collaborations and application of genome-wide association studies (GWAS), a number of susceptibility genes for primary sclerosing cholangitis (PSC) have been detected over the recent years. The genetic architecture of PSC resembles prototypical HLA...

...Johannes R. Hov; Verena Keitel; Erik Schrumpf; Dieter Häussinger; Tom H. Karlsen TGR5, the G-protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways and homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC), a chronic inflammatory bile...