...Baofeng Wang; Weili Min; Wenjie Zhang; Qiufang Liu; Xufeng Guo; Jianshui Zhan; Ming Lei; Ying Zan; Qingyong Ma; Hongbing Ma Background: Single nucleotide polymorphism (SNP) of candidate genes also affects the occurrence and prognosis of liver cancer. We mainly explored the effects of PIK3R3...

...Shuzi Zheng; Chaoqun Wu; Wei Yang; Xuanping Xia; Xiuqing Lin; Lijia Jiang; Ran Ding; Yi Jiang Objectives: The study aimed to investigate the association of Crohn's disease (CD) with transcobalamin II ( TCN2 ) polymorphisms and serum homocysteine, folate, and vitamin B 12 levels. Methods: TCN2...

... C virus. Nat Genet 2013;45:164-171. 5. Bibert S, Roger T, Calandra T, Bochud M, Cerny A, Semmo N, Duong FH, Gerlach T, Malinverni R, Moradpour D, Negro F, Müllhaupt B, Bochud PY; Swiss Hepatitis C Cohort Study: IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance...

... clearance and higher drug concentrations experienced superior acid suppression. Proton pump inhibitors are predominantly inactivated by the 2C19 isoform of the hepatic cytochrome P450 mixed function oxidase system. The cytochrome P450 2C19 gene is polymorphic, with three known inactivating mutations...